Cldn1 claudin 1 [Mus musculus] - Gene

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Summary

Official Symbol: Cldn1provided by MGI
Official Full Name: claudin 1provided by MGI
Primary source: MGI:1276109
See related: Ensembl:ENSMUSG00000022512; Vega:OTTMUSG00000022624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AI596271
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010]

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Genomic context

Location :: 16 B2; 16

Sequence :: Chromosome: 16; NC_000082.6 (26356645..26371839, complement)

See Cldn1 in Epigenomics, MapViewer

Chromosome 16 - NC_000082.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The tight junction protein claudin-1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3
Title: Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Mouse CLDN1 (mCLDN1) supported HCV genotype 2a infection with only moderate efficiency. indicating CLDN1 also contributes to the restricted species tropism of HCV. CLDN1 also contributes to the restricted species tropism of HCV.
Title: Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line.
This study investigated whether the conserved "dFynPl" sequence is essential for claudin-1, continuous strand-forming claudin, to form TJ strands
Title: Freeze-fracture electron microscopic study of tight junction strands in HEK293 cells and MDCK II cells expressing claudin-1 mutants in the second extracellular loop.
LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and the turnover of tight junctions is regulated by ubiquitylation.
Title: The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells.
The induction of tight-junction protein claudin-1 and paracellular permeability during the differentiation of osteoblast-like MC3T3-E1 cells after treatment with IGF-I is regulated via a MAP-kinase pathway, but not with respect to gap junctions.
Title: IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway.
Nectin plays a novel role in the co-localization of JAM and claudin at the same cell-cell adhesion membrane domains.
Title: Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain.
Claudin-1 is a p63 target gene with a crucial role in epithelial development
Title: Claudin-1 is a p63 target gene with a crucial role in epithelial development.
Cldn1 is localized in the epidermis and nail and in the dorsal surface of the tongue and glandular compartment of the stomach but is absent from the oral mucosa and the keratinized compartment of the stomach.
Title: Claudin immunolocalization in neonatal mouse epithelial tissues.
Claudin-1 was located in murine Langerhans cells (LC) in epidermis. TGF-beta stimulated accumulation of claudin-1 mRNA and protein when added to cultured bone marrow cells. Claudin-1 may have a function in adhesion and migration of LC.
Title: Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1.
dynamic behavior of paired strands of this protein in cell membranes
Title: Dynamic behavior of paired claudin strands within apposing plasma membranes.

Submit: New GeneRIF Correction See all (13)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_057883.1	NP_034950.1	Mpdz	BIND	PubMed	Cldn1 (Cld-1) interacts with Mpdz (MUPP1).
NP_057883.1	NP_033412.1	Tjp1	BIND	PubMed	Cldn1 (Cld-1) interacts with Tjp1 (ZO-1).
BioGRID:198743	BioGRID:201187	Lnx1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198743	BioGRID:201476	Mpdz	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:198743	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
calcium-independent cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
integral to membrane	NAS Non-traceable Author Statement more info	PubMed
lateral plasma membrane	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
tight junction	IDA Inferred from Direct Assay more info	PubMed
tight junction	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: claudin-1

Names: claudin-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016674.4 → NP_057883.1 claudin-1

Status: REVIEWED

Source sequence(s)

AK036780, CK626537

Consensus CDS

CCDS28087.1

UniProtKB/Swiss-Prot

O88551

UniProtKB/TrEMBL

Q4FJV3

Related

ENSMUSP00000023154, OTTMUSP00000025830, ENSMUST00000023154, OTTMUST00000054195

Conserved Domains (1) summary

cl15797
Location:5 – 169
Blast Score: 366

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000082.6 Reference GRCm38 C57BL/6J

Range

26356645..26371839, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000038.1 Alternate Mm_Celera

Range

26899933..26915115, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC108423.10 (129660..144848)	None
genomic	CH466521.1	EDK97687.1	mixed
mRNA	AF072127.1	AAC27078.1
mRNA	AK028428.1	BAC25945.1	C57BL/6J
mRNA	AK036762.1	BAC29567.1	C57BL/6J
mRNA	AK036780.1	BAC29574.1	C57BL/6J
mRNA	AK040604.1	BAC30640.1	C57BL/6J
mRNA	AK054207.1	BAC35693.1	C57BL/6J
mRNA	AK081601.1	BAC38267.1	C57BL/6J
mRNA	AK161125.1	None	C57BL/6J
mRNA	BC002003.1	AAH02003.1
mRNA	BC008536.1	None	CZECHII
mRNA	CK626537.1	None	C57BL/6J
mRNA	CT010299.1	CAJ18507.1
mRNA	EU076705.1	ABU50010.1	BALB/c