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Clcnka chloride channel, voltage-sensitive Ka [ Mus musculus (house mouse) ]

Gene ID: 12733, updated on 13-Aug-2016
Official Symbol
Clcnkaprovided by MGI
Official Full Name
chloride channel, voltage-sensitive Kaprovided by MGI
Primary source
MGI:MGI:1329026
See related
Ensembl:ENSMUSG00000033770 Vega:OTTMUSG00000010291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C75963; CLC-K1; Clcnk1
Summary
This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKB (geneID:1188). Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Sep 2009]
Location:
4; 4 E1
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (141384611..141398706, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (140940526..140954621, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene 13076 Neighboring gene family with sequence similarity 131, member C Neighboring gene predicted gene, 34693 Neighboring gene chloride channel, voltage-sensitive Kb

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
chloride ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
voltage-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
chloride transport IEA
Inferred from Electronic Annotation
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of body fluid levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
renal inner medulla development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
chloride channel protein ClC-Ka
Names
chloride channel K1
chloride channel Ka
putative basolateral cTAL chloride channel ClC-Ka

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146307.1NP_001139779.1  chloride channel protein ClC-Ka

    See identical proteins and their annotated locations for NP_001139779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY373832, BB743618, BG061970, CF725377
    Consensus CDS
    CCDS18871.1
    UniProtKB/Swiss-Prot
    Q9WUB7
    Related
    ENSMUSP00000101416, OTTMUSP00000010986, ENSMUST00000105790, OTTMUST00000023956
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:555676
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:106514
    Voltage_CLC; Voltage gated chloride channel
  2. NM_024412.3NP_077723.3  chloride channel protein ClC-Ka

    See identical proteins and their annotated locations for NP_077723.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY373832, BB743618, BG061970, CJ068439
    Consensus CDS
    CCDS18871.1
    UniProtKB/Swiss-Prot
    Q9WUB7
    Related
    ENSMUSP00000048520, OTTMUSP00000010985, ENSMUST00000042617, OTTMUST00000023955
    Conserved Domains (3) summary
    cd03683
    Location:49533
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:555676
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:106514
    Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    141384611..141398706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)