Official Symbol

CNTFRprovided by HGNC

Official Full Name

ciliary neurotrophic factor receptorprovided by HGNC

Primary Source

HGNC:2170

See related

Ensembl:ENSG00000122756; HPRD:00348; MIM:118946

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

MGC1774; CNTFR

Summary

This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

Preferred Names

ciliary neurotrophic factor receptor

Names

ciliary neurotrophic factor receptor

CNTFR alpha

ciliary neurotrophic factor receptor alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001842.3 → NP_001833.1  ciliary neurotrophic factor receptor preproprotein

   Description

   Transcript Variant: This variant (2) lacks a 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.

   Source sequence(s)

   BC001492,BI545014

   Consensus CDS

   CCDS6558.1

   UniProtKB/Swiss-Prot

   P26992

   UniProtKB/TrEMBL

   Q5U050

   Conserved Domains (2) summary

   cd00063
   Location:204 – 300
   Blast Score: 118

   FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...

   cl00093
   Location:39 – 96
   Blast Score: 126

   IG; Immunoglobulin domain family; members are components of immunoglobulins, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core...

2. NM_147164.1 → NP_671693.1  ciliary neurotrophic factor receptor preproprotein

   Description

   Transcript Variant: This variant (1) is the full-length transcript and encodes the same protein as variant 2.

   Source sequence(s)

   BC001492,BI545014,M73238

   Consensus CDS

   CCDS6558.1

   UniProtKB/Swiss-Prot

   P26992

   UniProtKB/TrEMBL

   Q5U050

   Conserved Domains (2) summary

   cd00063
   Location:204 – 300
   Blast Score: 118

   FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...

   cl00093
   Location:39 – 96
   Blast Score: 126

   IG; Immunoglobulin domain family; members are components of immunoglobulins, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000009.11

   Range

   34551430..34589721, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_008413.18 

   Range

   34541430..34579721, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000052.1

   Range

   34482939..34521224, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_924062.1 

   Range

   34367458..34405743, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000141.1

   Range

   34505792..34540343

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001839149.2 

   Range

   1327877..1362428

   Download

   GenBank FASTA Sequence Viewer (Graphics)