CNR1 cannabinoid receptor 1 (brain) [Homo sapiens] - Gene

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Summary

Official Symbol: CNR1provided by HGNC
Official Full Name: cannabinoid receptor 1 (brain)provided by HGNC
Primary source: HGNC:2159
Locus tag: RP1-23D17.1
See related: Ensembl:ENSG00000118432; HPRD:00259; MIM:114610; Vega:OTTHUMG00000015184
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
Summary: This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

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Genomic context

Location :: 6q14-q15

Sequence :: Chromosome: 6; NC_000006.11 (88849583..88875767, complement)

See CNR1 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings support previously reported associations of CNR1 with dependence to alcohol and other substances
Title: Cannabinoid receptor 1 gene is associated with alcohol dependence.
a novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH
Title: Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes.
we found no association of rs2023239 and rs806381 variants of CNR1 gene with overweight and obesity in Chinese female Han population
Title: Associations of variants of CNR1 with obesity and obesity-related traits in Chinese women.
The level of CB(1) receptor expression in colorectal cancer is associated with the tumour grade in a manner dependent upon the degree of CpG hypermethylation. A high CB(1)IR is indicative of a poorer prognosis in stage II microsatellite stable tumour.
Title: High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer.
CB1 receptor contributes to the rapid ischemic tolerance induced by electroacupuncture pretreatment against focal cerebral ischemia.
Title: Cannabinoid receptor type 2 activation yields delayed tolerance to focal cerebral ischemia.
Although supported by initial results, we found no reproducible statistical association of common variation at CNR1 with insulin resistance, type 2 diabetes, or coronary heart disease.
Title: Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.
CB1 receptor antagonism may impair cognitive performance by a disturbed interaction between endocannabinergic activity and glutamatergic neurotransmission implied in schizophrenia
Title: Inhibition of cerebral type 1 cannabinoid receptors is associated with impaired auditory mismatch negativity generation in the ketamine model of schizophrenia.
Study indicates that the rs1049353 polymorphism of the CNR1 gene is associated with decreased levels of adiponectin.
Title: The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia.
Upregulated CB1 receptor expression in paranoid schizophrenia leads to increased CB1 receptor binding in the dorsolateral prefrontal cortex.
Title: Paranoid schizophrenia is characterized by increased CB1 receptor binding in the dorsolateral prefrontal cortex.
Further genotyping of the endocannabinoid receptor gene cannot be used as a significant marker of predisposition to cardiovascular diseases in postmenopausal women.
Title: Endocannabinoid type 1 receptor gene (CNR1) polymorphisms (rs806381, rs10485170, rs6454674, rs2023239) and cardiovascular risk factors in postmenopausal women.

Submit: New GeneRIF Correction See all (209)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000006.9	NP_778224.1	HIST4H4	BIND	PubMed	HIST4H4 (histone H4) interacts with the CNR1 promoter.
NC_000006.9		PAX3	BIND	PubMed	An unspecified isoform of PAX3 interacts with the CNR1 promoter.
NC_000006.9	AAC50053.1		BIND	PubMed	Pax3/FKHR interacts with the CNR1 promoter.
P21554	P30679	GNA15	HPRD	PubMed
P21554	P63096	GNAI1	HPRD	PubMed
P21554	P04899	GNAI2	HPRD	PubMed
P21554	P08754	GNAI3	HPRD	PubMed
P21554	O43613	HCRTR1	HPRD	PubMed
P21554	P08581	MET	HPRD	PubMed
BioGRID:107668	BioGRID:109032	GNAI1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107668	BioGRID:109033	GNAI2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107668	BioGRID:109035	GNAI3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107668	BioGRID:111844	RAP1GAP	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
cannabinoid receptor activity	IDA Inferred from Direct Assay more info	PubMed
drug binding	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein signaling, coupled to cAMP nucleotide second messenger	IDA Inferred from Direct Assay more info	PubMed
G-protein signaling, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
aging	IEA Inferred from Electronic Annotation more info
behavior	TAS Traceable Author Statement more info	PubMed
maternal process involved in female pregnancy	IEA Inferred from Electronic Annotation more info
memory	IEA Inferred from Electronic Annotation more info
negative regulation of action potential	IEA Inferred from Electronic Annotation more info
negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
negative regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
negative regulation of fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
negative regulation of ion transport	IEA Inferred from Electronic Annotation more info
negative regulation of mast cell activation	IEA Inferred from Electronic Annotation more info
negative regulation of nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info
positive regulation of acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
positive regulation of fever generation	IEA Inferred from Electronic Annotation more info
positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info
regulation of penile erection	IEA Inferred from Electronic Annotation more info
regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
response to cocaine	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to morphine	IEA Inferred from Electronic Annotation more info
response to nicotine	IEA Inferred from Electronic Annotation more info
response to nutrient	IEA Inferred from Electronic Annotation more info
response to stress	IEA Inferred from Electronic Annotation more info
sensory perception of pain	IEA Inferred from Electronic Annotation more info
spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
microsome	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: cannabinoid receptor 1

Names: cannabinoid receptor 1; central cannabinoid receptor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160226.1 → NP_001153698.1 cannabinoid receptor 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 5 all encode isoform a. This variant was designated CB1B by PubMed ID: 15289816.

Source sequence(s)

AL121835, AL136096

Consensus CDS

CCDS5015.1

UniProtKB/Swiss-Prot

P21554

Conserved Domains (2) summary

pfam00001
Location:139 – 397
Blast Score: 418

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:134 – 412
Blast Score: 125

7tm_4; Olfactory receptor
NM_001160258.1 → NP_001153730.1 cannabinoid receptor 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains two alternate exons in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 5 all encode isoform a. This variant was designated CB1C by PubMed ID: 15289816.

Source sequence(s)

AL121835, AL136096

Consensus CDS

CCDS5015.1

UniProtKB/Swiss-Prot

P21554

Related

ENSP00000446702, OTTHUMP00000241185, ENST00000551417, OTTHUMT00000404177

Conserved Domains (2) summary

pfam00001
Location:139 – 397
Blast Score: 418

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:134 – 412
Blast Score: 125

7tm_4; Olfactory receptor
NM_001160259.1 → NP_001153731.1 cannabinoid receptor 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 5 all encode isoform a. This variant was designated CB1D by PubMed ID: 15289816.

Source sequence(s)

AL121835, AL136096

Consensus CDS

CCDS5015.1

UniProtKB/Swiss-Prot

P21554

Related

ENSP00000442689, ENST00000535130

Conserved Domains (2) summary

pfam00001
Location:139 – 397
Blast Score: 418

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:134 – 412
Blast Score: 125

7tm_4; Olfactory receptor
NM_016083.4 → NP_057167.2 cannabinoid receptor 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variant 1 has also been called CB1A by PubMed ID: 15289816. Variants 1, 3, 4 and 5 all encode isoform a.

Source sequence(s)

AL121835, BM682178, BX538191, DA128033, DA768458, X54937, X81120

Consensus CDS

CCDS5015.1

UniProtKB/Swiss-Prot

P21554

Related

ENSP00000358513, OTTHUMP00000016838, ENST00000369501, OTTHUMT00000041461

Conserved Domains (2) summary

pfam00001
Location:139 – 397
Blast Score: 418

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:134 – 412
Blast Score: 125

7tm_4; Olfactory receptor
NM_033181.3 → NP_149421.2 cannabinoid receptor 1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal segment near the 5' end of the coding region, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a. PubMed ID: 15620723 referred to this variant and its protein as CB1b.

Source sequence(s)

AY766182, BM682178, BX538191, DA239984, DA793373, DA799263, X54937, X81120

Consensus CDS

CCDS5016.2

UniProtKB/Swiss-Prot

P21554

Related

ENSP00000420188, OTTHUMP00000214579, ENST00000468898, OTTHUMT00000354203

Conserved Domains (2) summary

pfam00001
Location:106 – 364
Blast Score: 411

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:101 – 379
Blast Score: 123

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

88849583..88875767, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

86064928..86090983, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001160260.1: Suppressed sequence

Description

NM_001160260.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL121835.18 (100..9360)	None
genomic	AL136096.7	CAB96726.1
		CAI19916.1
genomic	AL136096.7	CAB96726.1
		CAI19916.1
genomic	AY011601.1	AAG37765.1
genomic	AY225225.1	AAO67710.1
genomic	CH471051.2	EAW48574.1
		EAW48575.1
		EAW48576.1
genomic	U73304.1	AAB18200.1
mRNA	AF107262.1	AAD34320.1
mRNA	AK313908.1	BAG36631.1
mRNA	AY766182.1	AAV35030.1
mRNA	AY995204.1	AAY21179.1
mRNA	BC074811.2	AAH74811.1
mRNA	BC074812.2	AAH74812.1
mRNA	BC095513.1	AAH95513.1
mRNA	BC100968.1	AAI00969.1
mRNA	BC100969.1	AAI00970.1
mRNA	BC100970.1	AAI00971.1
mRNA	BC100971.1	AAI00972.1
mRNA	BM682178.1	None
mRNA	BX538191.1	None
mRNA	DA128033.1	None
mRNA	DA239984.1	None
mRNA	DA768458.1	None
mRNA	DA793373.1	None
mRNA	DA799263.1	None
mRNA	DQ067455.1	AAY68486.1
mRNA	X54937.1	CAA38699.1
mRNA	X81120.1	CAA57018.1
mRNA	X81121.1	CAA57019.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P21554.1	GenPept	UniProtKB/Swiss-Prot:P21554
Q506J9	GenPept	UniProtKB/TrEMBL:Q506J9
Q9BYY6	GenPept	UniProtKB/TrEMBL:Q9BYY6