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Chka choline kinase alpha [ Mus musculus (house mouse) ]

Gene ID: 12660, updated on 8-May-2016
Official Symbol
Chkaprovided by MGI
Official Full Name
choline kinase alphaprovided by MGI
Primary source
MGI:MGI:107760
See related
Ensembl:ENSMUSG00000024843 Vega:OTTMUSG00000029650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK; EK; Chk; ChoK; EtnK-alpha; CK/EK-alpha; Chetk-alpha
Orthologs
Location:
19 A; 19 3.57 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (3851585..3894369)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (3851773..3894367)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene suppressor of variegation 4-20 homolog 1 (Drosophila) Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
choline binding ISO
Inferred from Sequence Orthology
more info
 
choline kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
choline kinase activity ISO
Inferred from Sequence Orthology
more info
 
cholinesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
ethanolamine kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
choline metabolic process ISO
Inferred from Sequence Orthology
more info
 
ethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
choline kinase alpha
Names
choline/ethanolamine kinase alpha
ethanolamine kinase
NP_001258425.1
NP_038518.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271496.1NP_001258425.1  choline kinase alpha isoform 3

    See identical proteins and their annotated locations for NP_001258425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC133523
    Consensus CDS
    CCDS70913.1
    UniProtKB/Swiss-Prot
    O54804
    Related
    ENSMUSP00000025760, OTTMUSP00000038092, ENSMUST00000025760, OTTMUST00000073551
    Conserved Domains (2) summary
    PLN02236
    Location:95451
    PLN02236; choline kinase
    cd05156
    Location:107448
    ChoK_euk; Euykaryotic Choline Kinase
  2. NM_013490.4NP_038518.2  choline kinase alpha isoform 1

    See identical proteins and their annotated locations for NP_038518.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC133523, AK005057, AK053818
    Consensus CDS
    CCDS29400.1
    UniProtKB/Swiss-Prot
    O54804
    Related
    ENSMUSP00000071933, OTTMUSP00000038091, ENSMUST00000072055, OTTMUST00000073550
    Conserved Domains (2) summary
    PLN02236
    Location:95433
    PLN02236; choline kinase
    cd05156
    Location:107430
    ChoK_euk; Euykaryotic Choline Kinase

RNA

  1. NR_073190.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC133523
    Related
    ENSMUST00000128694, OTTMUST00000073552

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    3851585..3894369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531646.1XP_006531709.1  

    Conserved Domains (2) summary
    PLN02236
    Location:95461
    PLN02236; choline kinase
    cd05156
    Location:107458
    ChoK_euk; Euykaryotic Choline Kinase
  2. XM_006531648.1XP_006531711.1  

    See identical proteins and their annotated locations for XP_006531711.1

    Conserved Domains (1) summary
    cd05156
    Location:1276
    ChoK_euk; Euykaryotic Choline Kinase
  3. XM_011248599.1XP_011246901.1  

    See identical proteins and their annotated locations for XP_011246901.1

    Conserved Domains (1) summary
    cd05156
    Location:1276
    ChoK_euk; Euykaryotic Choline Kinase
  4. XM_006531651.2XP_006531714.1  

    See identical proteins and their annotated locations for XP_006531714.1

    Conserved Domains (1) summary
    cd05156
    Location:1276
    ChoK_euk; Euykaryotic Choline Kinase
  5. XM_011248601.1XP_011246903.1  

    See identical proteins and their annotated locations for XP_011246903.1

    Conserved Domains (1) summary
    cd05156
    Location:1276
    ChoK_euk; Euykaryotic Choline Kinase
  6. XM_011248600.1XP_011246902.1  

    See identical proteins and their annotated locations for XP_011246902.1

    Conserved Domains (1) summary
    cd05156
    Location:1276
    ChoK_euk; Euykaryotic Choline Kinase
  7. XM_006531650.1XP_006531713.1  

    See identical proteins and their annotated locations for XP_006531713.1

    Conserved Domains (1) summary
    cd05156
    Location:1276
    ChoK_euk; Euykaryotic Choline Kinase
  8. XM_006531649.1XP_006531712.1  

    See identical proteins and their annotated locations for XP_006531712.1

    Conserved Domains (1) summary
    cd05156
    Location:1276
    ChoK_euk; Euykaryotic Choline Kinase

RNA

  1. XR_388248.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    3732122..3774744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025566.1: Suppressed sequence

    Description
    NM_001025566.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.