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    PLK5 polo-like kinase 5 [ Homo sapiens (human) ]

    Gene ID: 126520, updated on 30-Apr-2013
    Official Symbol
    PLK5provided by HGNC
    Official Full Name
    polo-like kinase 5provided by HGNC
    Primary source
    HGNC:27001
    See related
    Ensembl:ENSG00000185988; Vega:OTTHUMG00000180073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLK-5; PLK5P; SgK384ps
    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (1524073..1535455)
    See PLK5 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 6 Neighboring gene ADAMTS-like 5 Neighboring gene mex-3 homolog D (C. elegans) Neighboring gene methyl-CpG binding domain protein 3

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. de Cárcer G, et al. Mol Cell Biol, 2011 Mar. PMID 21245385.
    2. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. Zhang ZD, et al. Genome Biol, 2010. PMID 20210993.
    3. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Andrysik Z, et al. Nucleic Acids Res, 2010 May. PMID 20100802.
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The human polo-like kinase 5 gene is significantly silenced in astrocytoma and glioblastoma multiforme by promoter hypermethylation, suggesting a tumor suppressor function for this gene.
      Title: Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Markers

    Genotypes

    Clone Names

    • MGC118807, MGC118808

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G2 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		  
    defense response to tumor cell IDA
    Inferred from Direct Assay
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		  
    transformed cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    inactive serine/threonine-protein kinase PLK5
    Names
    inactive serine/threonine-protein kinase PLK5
    polo-like kinase 5, pseudogene
    NP_001230008.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243079.1 → NP_001230008.1  inactive serine/threonine-protein kinase PLK5

      Status: VALIDATED

      Source sequence(s)
      AC027307, AI651075, AK054808, BC100791
      Consensus CDS
      CCDS59328.1
      UniProtKB/Swiss-Prot
      Q496M5
      Related
      ENSP00000468376, OTTHUMP00000263273, ENST00000454744, OTTHUMT00000449627
      Conserved Domains (1) summary
      cl09925
      Location:1 – 65
      Blast Score: 137
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      1524073..1535455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      1298745..1309489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      1452880..1464087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001011716.1: Suppressed sequence

      Description
      NM_001011716.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

    2. NR_026557.1: Suppressed sequence

      Description
      NR_026557.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01002653.1 (781..7195) None
    genomic ABBA01002654.1 None
    genomic AC027307.5 (113897..125279) None
    genomic AMYH01009252.1 (23205..34412) None
    mRNA AI651075.1 None
    mRNA AK054808.1 BAG51426.1
    mRNA AK122648.1 BAG53640.1
    mRNA BC100791.2 None
    mRNA BC100792.1 None
    mRNA BC100793.2 None
    mRNA BF364682.1 None
    mRNA DA058511.1 None
    mRNA DQ424898.1 ABD83663.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q496M5.4 GenPept UniProtKB/Swiss-Prot:Q496M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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