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Chga chromogranin A [ Mus musculus (house mouse) ]

Gene ID: 12652, updated on 21-May-2016
Official Symbol
Chgaprovided by MGI
Official Full Name
chromogranin Aprovided by MGI
Primary source
MGI:MGI:88394
See related
Ensembl:ENSMUSG00000021194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cgA; ChrA
Summary
This gene encodes a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. The encoded preproprotein undergoes proteolytic processing to generate multiple functions peptides including pancreastatin, catestatin and serpinin. The encoded protein plays important roles in the neuroendocrine system including regulated secretion of peptide hormones and neurotransmitters. Mice lacking the encoded protein exhibit elevated blood pressure which can be rescued by transgenic expression of the human ortholog. [provided by RefSeq, Nov 2015]
Orthologs
Location:
12 E; 12 51.66 cM
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (102554969..102565027)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (103793179..103803237)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30198 Neighboring gene golgi autoantigen, golgin subfamily a, 5 Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase Neighboring gene microRNA 1936 Neighboring gene predicted gene, 40559

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adrenergic receptor signaling pathway involved in cardiac muscle relaxation ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
mast cell activation ISO
Inferred from Sequence Orthology
more info
 
mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
mast cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of catecholamine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
organelle organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dense core granule biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromaffin granule ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
secretory granule ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007693.2NP_031719.1  chromogranin-A preproprotein

    See identical proteins and their annotated locations for NP_031719.1

    Status: REVIEWED

    Source sequence(s)
    BY250052, M64278
    Consensus CDS
    CCDS26120.1
    UniProtKB/Swiss-Prot
    P26339
    Related
    ENSMUSP00000021610, ENSMUST00000021610
    Conserved Domains (1) summary
    pfam01271
    Location:25463
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    102554969..102565027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    103769159..103779238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)