Cebpa CCAAT/enhancer binding protein (C/EBP), alpha [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cebpaprovided by MGI
Official Full Name: CCAAT/enhancer binding protein (C/EBP), alphaprovided by MGI
Primary source: MGI:99480
See related: Ensembl:ENSMUSG00000034957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cebp; CBF-A; C/ebpalpha

Genomic context

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Location :: 7 B1; 7 21.02 cM

Sequence :: Chromosome: 7; NC_000073.6 (35119293..35121928)

See Cebpa in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

C/ebpalpha promoter activation at the onset of adipogenesis is mediated by C/EBPbeta and HDAC1 interaction.
Title: A positive regulatory domain in CCAAT/enhancer binding protein β (C/EBPΒ) is required for the glucocorticoid-mediated displacement of histone deacetylase 1 (HDAC1) from the C/ebpα promoter and maximum adipogenesis.
Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor gamma and C/EBPalpha.
Title: Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor γ and C/EBPα.
Tob2 protein suppresses PPARgamma2 transcription by inhibiting BMP2-induced Smad1/5 phosphorylation through its interaction with Smad6 and by sequestering C/EBPalpha from the PPARgamma2 promoter.
Title: Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation.
Exposure of mice and HL-60 cells to 3 Grays of gamma-radiation led to increased NQO1 that stabilized C/EBPalpha against 20S proteasomal degradation.
Title: NAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20S proteasome for binding with C/EBPα leading to its stabilization and protection against radiation-induced myeloproliferative disease.
the current data combined with previous data suggest that stress induction of NQO1 through both stabilization of C/EBPalpha and increase in p63 and direct stabilization of p63 controls keratinocyte differentiation
Title: Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer.
data support a model in which members of C/EBP family transcription factors are activated in the epicardium in response to both developmental cues and injury signals and function with other transcription factors to establish a transcriptional code for embryonic gene expression in the epicardium
Title: C/EBP transcription factors mediate epicardial activation during heart development and injury.
CEBPA regulates the expression of serine protease inhibitors that are required for the normal increase of fibronectin and the restoration of ciliated cells after lung injury.
Title: CCAAT/enhancer binding protein-α regulates the protease/antiprotease balance required for bronchiolar epithelium regeneration.
C/EBP alpha overexpression in vivo blocks repression of hepcidin by ethanol treatment.
Title: The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.
the aberrant feed-forward pathway that keeps eIF4E and C/EBPalphap30 elevated in NPM1(+/-) cells contributes to the MDS phenotype associated with NPM1 deficiency.
Title: Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.
In the mouse, HNF4alpha has a direct and essential regulatory role for multiple hepatic coagulation genes, while a role for C/EBPalpha is more restricted.
Title: Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.

Submit: New GeneRIF Correction See all (140)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (3) 1 citation
Targeted (knock-out) (6) 1 citation
Chemically induced (ENU) (1) 1 citation
Targeted (knock-in) (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_031704.1	M20497.1	Fabp4	BIND	PubMed	C/EBP-alpha interacts with p-422/aP2.
NP_031704.1	NP_598775.2	Xpo1	BIND	PubMed	Phosphorylated C/EBP-alpha interacts with CRM1.
NP_031704.1	NT_081341.2		BIND	PubMed	C/EBP-alpha interacts with p-C/EBP-alpha.
NP_031704.1	S79407.1		BIND	PubMed	C/EBP-alpha interacts with p-PPAR-gamma.
BioGRID:198667	BioGRID:198624	Cdk1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:198667	BioGRID:198644	Cdk2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:198645	Cdk4	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:198667	BioGRID:199078	Ddit3	BioGRID	PubMed	Two-hybrid
BioGRID:198667	BioGRID:236625	Ep300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:219888	Jdp2	BioGRID	PubMed	Two-hybrid
BioGRID:198667	BioGRID:201709	Ncoa3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:207302	Psmd10	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:202815	Rb1	BioGRID	PubMed	Reconstituted Complex
BioGRID:198667	BioGRID:202819	Rbl1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:112614	SRY	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:222977	Sharpin	BioGRID	PubMed	Affinity Capture-MS
BioGRID:198667	BioGRID:248015	Sox10	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:203412	Sox8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198667	BioGRID:229263	Trib1	BioGRID	PubMed	Reconstituted Complex
BioGRID:198667	BioGRID:229913	Trib2	BioGRID	PubMed	Reconstituted Complex
BioGRID:198667	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

M62362 (e-PCR)
- UniSTS:124964

BE096629 (e-PCR)
- UniSTS:244045

M62362 (e-PCR)
- UniSTS:179555

NoName (e-PCR)
- UniSTS:235647

Cebpa (e-PCR), detects polymorphism
- UniSTS:516500

RH141409 (e-PCR)
- UniSTS:223404

Cebpa (e-PCR), detects polymorphism
- UniSTS:527283

PMC94247P1 (e-PCR)
- UniSTS:273622

Cebpa (e-PCR), detects polymorphism
- UniSTS:465371

PMC117301P1 (e-PCR)
- UniSTS:270326

PMC117301P2 (e-PCR)
- UniSTS:270327

Homology

Homologs of the Cebpa gene: The Cebpa gene is conserved in human, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	ISO Inferred from Sequence Orthology more info
HMG box domain binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
protein domain specific binding	ISO Inferred from Sequence Orthology more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
transcription factor binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
cytokine-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
embryonic placenta development	IGI Inferred from Genetic Interaction more info	PubMed
fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
inner ear development	IDA Inferred from Direct Assay more info
liver development	IMP Inferred from Mutant Phenotype more info	PubMed
lung development	IMP Inferred from Mutant Phenotype more info	PubMed
macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase III promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
urea cycle	IDA Inferred from Direct Assay more info	PubMed
white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Rb-E2F complex	ISO Inferred from Sequence Orthology more info
nuclear matrix	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCAAT/enhancer-binding protein alpha

Names: CCAAT/enhancer-binding protein alpha; C/EBP alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007678.3 → NP_031704.2 CCAAT/enhancer-binding protein alpha

Status: VALIDATED

Source sequence(s)

AC150683, AW045436

Consensus CDS

CCDS21145.1

UniProtKB/Swiss-Prot

P53566

Related

ENSMUSP00000096129, ENSMUST00000042985

Conserved Domains (1) summary

pfam07716
Location:282 – 335
Blast Score: 159

bZIP_2; Basic region leucine zipper

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

35119293..35121928

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

30255122..30257756

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01060488.1 (38092..40726)	None
genomic	AC150683.3 (50041..52675)	None
genomic	CH466618.2	EDL03027.1	mixed
genomic	M62362.1	AAA37374.1
mRNA	AK155281.1	BAE33162.1	NOD
mRNA	AK160443.1	None	C57BL/6J
mRNA	AW045436.1	None	C57BL/6J
mRNA	BC011118.1	AAH11118.1	FVB/N
mRNA	BC028890.1	AAH28890.1	FVB/N
mRNA	BC051102.1	AAH51102.1	FVB/N
mRNA	BC058161.1	AAH58161.1	FVB/N
mRNA	BC106174.1	None	FVB/N