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Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [ Mus musculus (house mouse) ]

Gene ID: 12580, updated on 17-May-2016
Official Symbol
Cdkn2cprovided by MGI
Official Full Name
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)provided by MGI
Primary source
MGI:MGI:105388
See related
Ensembl:ENSMUSG00000028551 Vega:OTTMUSG00000008484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p18; INK4c; C77269; p18-INK6; p18INK4c; p18-INK4c
Summary
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]
Orthologs
Location:
4 C7; 4 51.32 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (109660876..109666756, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (109333481..109337977, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630013D21 gene Neighboring gene predicted gene, 40227 Neighboring gene Fas-associated factor 1 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cyclin-dependent kinase 4 inhibitor C
Names
cyclin-dependent kinase 6 inhibitor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301368.1NP_001288297.1  cyclin-dependent kinase 4 inhibitor C

    See identical proteins and their annotated locations for NP_001288297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as p18(L)) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA189303, AK003933, AL627392, BG085472
    Consensus CDS
    CCDS18467.1
    UniProtKB/Swiss-Prot
    Q60772
    UniProtKB/TrEMBL
    Q9D153
    Related
    ENSMUSP00000095534, OTTMUSP00000008831, ENSMUST00000097921, OTTMUST00000019256
    Conserved Domains (3) summary
    cd00204
    Location:37156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9100
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:89144
    Ank_5; Ankyrin repeats (many copies)
  2. NM_007671.3NP_031697.1  cyclin-dependent kinase 4 inhibitor C

    See identical proteins and their annotated locations for NP_031697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as p18(S)) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA189303, AK003933, AL627392, BF657811
    Consensus CDS
    CCDS18467.1
    UniProtKB/Swiss-Prot
    Q60772
    UniProtKB/TrEMBL
    Q9D153
    Related
    ENSMUSP00000070313, OTTMUSP00000008832, ENSMUST00000063531, OTTMUST00000019257
    Conserved Domains (3) summary
    cd00204
    Location:37156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9100
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:89144
    Ank_5; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    109660876..109666756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    108000724..108006584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)