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Cdkn1b cyclin-dependent kinase inhibitor 1B [ Mus musculus (house mouse) ]

Gene ID: 12576, updated on 26-Apr-2016
Official Symbol
Cdkn1bprovided by MGI
Official Full Name
cyclin-dependent kinase inhibitor 1Bprovided by MGI
Primary source
MGI:MGI:104565
See related
Ensembl:ENSMUSG00000003031 Vega:OTTMUSG00000021172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p27; Kip1; p27Kip1; AA408329; AI843786
Orthologs
Location:
6 G1; 6 65.77 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (134920401..134925525)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (134870419..134875543)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 19 Neighboring gene predicted gene, 40407 Neighboring gene RIKEN cDNA 2810454H06 gene Neighboring gene lncRNA downstream of Cdkn1b Neighboring gene predicted gene, 36428 Neighboring gene apolipoprotein L domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
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    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell death ISO
Inferred from Sequence Orthology
more info
 
cellular response to antibiotic IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular component movement IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microtubule polymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
potassium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cyclin-dependent kinase inhibitor 1B
Names
cyclin-dependent kinase inhibitor p27

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009875.4NP_034005.2  cyclin-dependent kinase inhibitor 1B

    See identical proteins and their annotated locations for NP_034005.2

    Status: VALIDATED

    Source sequence(s)
    AC122193, U10440
    Consensus CDS
    CCDS20642.1
    UniProtKB/Swiss-Prot
    P46414
    Related
    ENSMUSP00000003115, OTTMUSP00000023377, ENSMUST00000003115, OTTMUST00000050154
    Conserved Domains (1) summary
    pfam02234
    Location:3080
    CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    134920401..134925525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    137877174..137882301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)