Cdkn1b cyclin-dependent kinase inhibitor 1B [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cdkn1bprovided by MGI
Official Full Name: cyclin-dependent kinase inhibitor 1Bprovided by MGI
Primary source: MGI:104565
See related: Ensembl:ENSMUSG00000003031; Vega:OTTMUSG00000021172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p27; Kip1; p27Kip1; AA408329; AI843786

Genomic context

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Location :: 6 G1; 6 65.77 cM

Sequence :: Chromosome: 6; NC_000072.6 (134920401..134925525)

See Cdkn1b in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show overexpression of pro-IL-16 impaired resting B cell proliferation mediated through regulating nuclear factor (NF)-kappaB activation, and siRNA knock-down of pro-IL-16 expression decreased the level of p27(kip) and increased the level of Skp2.
Title: Pro-IL-16 is associated with MHC class II-mediated negative regulation of mouse resting B cell activation through MAP kinases, NF-κB and Skp2-dependent p27kip regulation.
Adam23 knockdown up-regulates P27KIP1 in P19/ADAM23 knockdown cells, one reason that P19/ADAM23 knockdown cells can differentiate into neurons without retinoic acid induction.
Title: ADAM23 knockdown promotes neuronal differentiation of P19 embryonal carcinoma cells by up-regulating P27KIP1 expression.
Our results point to p27 as a critical regulator of Treg cell differentiation and function through the positive modulation of TGFbeta signaling strength in T cells.
Title: p27(Kip1) inhibits systemic autoimmunity through the control of Treg cell activity and differentiation.
The cell cycle inhibitors p27 and p57 synergistically regulate podocyte numbers and glomerular size in mice.
Title: Glomerular differentiation in p27 and p57 double-mutant metanephroi.
Cyclin A47 was fully inhibited during the M-to-G1 transition in p21(-/-) p27(-/-) fibroblasts.
Title: Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107.
The p27(Kip1) cell-autonomously controls nucleokinesis and neurite branching by regulating both actin and microtubule cytoskeletons.
Title: p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration.
p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory.
Title: p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory.
We report here a new cellular function of p27 as a transcriptional regulator in association with p130/E2F4 complexes that could be relevant for tumorigenesis.
Title: p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes.
This study demonistrated that Sox2 or p27(Kip1) expression is an effective approach to inducing proliferation of neonatal auditory inner pillar cells.
Title: Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.
our results demonstrated that miR-221 regulated cardiomyocyte hypertrophy probably through down-regulation of p27
Title: MiR-221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression.

Submit: New GeneRIF Correction See all (225)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (5) 1 citation
Targeted (knock-in) (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AK047669.1	AAC99454.1	Qk	BIND	PubMed	QKI-6 binds to p27Kip1 mRNA
AK047669.1	NP_068681.1	Qk	BIND	PubMed	QKI-7 binds to p27Kip1 mRNA
NP_034005.2	NP_033958.1	Ccna2	BIND	PubMed	Cdkn1b (p27) interacts with Ccna2 (cyclin A2).
NP_034005.2	NP_033958.1	Ccna2	BIND	PubMed	Cdkn1b (p27) interacts with Ccna2 (cyclin A).
NP_034005.2	NP_758505.2	Ccnb1	BIND	PubMed	Cdkn1b (p27) interacts with Ccnb1 (cyclin B1).
NP_034005.2	NP_031657.1	Ccnd1	BIND	PubMed	Cyclin D1 interacts with p27.
NP_034005.2	NP_033959.1	Ccnd2	BIND	PubMed	Ccnd2 (Cyclin D2) interacts with Cdkn1b (p27).
NP_034005.2	NP_031658.1	Ccnd3	BIND	PubMed	Ccnd3 (Cyclin D3) interacts with Cdkn1b (p27).
NP_034005.2	NP_031659.1	Ccne1	BIND	PubMed	Cdkn1b (p27) interacts with Ccne1 (cyclin E1).
NP_034005.2	NP_031659.1	Ccne1	BIND	PubMed	Ccne1 (Cyclin E) interacts, albeit weakly, with Cdkn1b (p27). This interaction was modeled on a demonstrated interaction between human Ccne1 (Cyclin E) and mouse Cdkn1b (p27).
NP_034005.2	NP_031685.2	Cdk1	BIND	PubMed	Cdkn1b (p27) interacts with Cdc2.
NP_034005.2	NP_058036.1	Cdk2	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2 (p33).
NP_034005.2	NP_058036.1	Cdk2	BIND	PubMed	CDK2 isoform 2 interacts with p27Kip1.
NP_034005.2	NP_904326.1	Cdk2	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2 (p38).
NP_034005.2	NP_904326.1	Cdk2	BIND	PubMed	CDK2 isoform 1 interacts with p27Kip1.
NP_034005.2		Cdk2	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2.
NP_034005.2		Cdk2	BIND	PubMed	An unspecified isoform of Cdk2 interacts, albeit weakly, with Cdkn1b (p27). This interaction was modeled on a demonstrated interaction between Cdk2 from an unspecified species and mouse Cdkn1b (p27).
NP_034005.2		Cdk2	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2. This interaction was modeled on a demonstrated interaction between Cdkn1b from an unspecified species and Xenopus Cdk2.
NP_034005.2	NP_034000.1	Cdk4	BIND	PubMed	Cdkn1b (p27) interacts with Cdk4.
NP_034005.2	NP_034000.1	Cdk4	BIND	PubMed	Cdkn1b (p27) interacts with Cdk4.
NP_034005.2	NP_034000.1	Cdk4	BIND	PubMed	Cdkn1b (p27) interacts with Cdk4. This interaction was modeled on a demonstrated interaction between Cdkn1b from an unspecified species and Xenopus Cdk4.
NP_034005.2	NP_058600.1	Cks1b	BIND	PubMed	Cdkn1b (p27) interacts with Cks1b (suc1).
NP_034005.2	NP_062615.1	Stmn1	BIND	PubMed	p27 interacts with stathmin.
NP_034005.2			BIND	PubMed	Cdkn1b (p27) interacts with the Cdk2-CcnA2 (A2.Cdk2) complex.
NP_034005.2			BIND	PubMed	Cdkn1b interacts with the Cdk4-Ccnd1 (D1.Cdk4) complex.
U51681.1	NP_034979.2	Myc	BIND	PubMed	Myc interacts with the Cdkn1b (p27) promoter.
BioGRID:198652	BioGRID:107338	CCNE1	BioGRID	PubMed	Reconstituted Complex
BioGRID:198652	BioGRID:107452	CDK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:198652	BioGRID:198545	Ccna2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:198548	Ccnd1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:198549	Ccnd2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:198550	Ccnd3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:247241	Ccnd3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:198552	Ccne1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:198644	Cdk2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:198652	BioGRID:198645	Cdk4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:198649	Cdk6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:205030	Cops5	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:198652	BioGRID:200857	Jak2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:201817	Nup50	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:198652	BioGRID:202815	Rb1	BioGRID	PubMed	Biochemical Activity
BioGRID:198652	BioGRID:220011	Rnf123	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:128828	SPDYA	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:198652	BioGRID:203998	Skp1a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:205208	Skp2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:204340	Tsc2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198652	BioGRID:113164	UBC	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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AKT phosphorylates targets in the cytosol, organism-specific biosystem (from REACTOME)
AKT phosphorylates targets in the cytosol, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
Cell cycle signaling pathway, organism-specific biosystem
Cell cycle signaling pathway
Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
Chronic myeloid leukemia, conserved biosystem (from KEGG)
Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
Cyclin D associated events in G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
Cyclin E associated events during G1/S transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
G1 Phase, organism-specific biosystem (from REACTOME)
G1 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
G1/S DNA Damage Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-5 Signaling Pathway, organism-specific biosystem
IL-5 Signaling Pathway
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
Ovarian Infertility Genes, organism-specific biosystem
Ovarian Infertility Genes
PI-3K cascade, organism-specific biosystem (from REACTOME)
PI-3K cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
PI3K/Akt/mTOR signaling pathway
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
Signaling by FGFR in disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Small cell lung cancer, organism-specific biosystem (from KEGG)
Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
Small cell lung cancer, conserved biosystem (from KEGG)
Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
p53-Dependent G1 DNA Damage Response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Cdkn1b (e-PCR), detects polymorphism
- UniSTS:468000

Cdkn1b (e-PCR), detects polymorphism
- UniSTS:164681

PMC140666P1 (e-PCR)
- UniSTS:270954

PMC87223P1 (e-PCR)
- UniSTS:273586

PMC87223P2 (e-PCR)
- UniSTS:273587

PMC87223P3 (e-PCR)
- UniSTS:273588

PMC126040P1 (e-PCR)
- UniSTS:270519

PMC317217P1 (e-PCR)
- UniSTS:273082

PMC307617P3 (e-PCR)
- UniSTS:272582

RH124702 (e-PCR)
- UniSTS:161524

AI843786 (e-PCR)
- UniSTS:164346

Homology

Homologs of the Cdkn1b gene: The Cdkn1b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
chaperone binding	ISO Inferred from Sequence Orthology more info
cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
autophagic cell death	ISO Inferred from Sequence Orthology more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
cell cycle arrest	ISO Inferred from Sequence Orthology more info
cell death	ISO Inferred from Sequence Orthology more info
cellular response to antibiotic	IDA Inferred from Direct Assay more info	PubMed
cellular response to lithium ion	ISO Inferred from Sequence Orthology more info	PubMed
cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
induction of apoptosis	ISO Inferred from Sequence Orthology more info
inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic cell cycle arrest	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of cellular component movement	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of kinase activity	ISO Inferred from Sequence Orthology more info
negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of cell death	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of microtubule polymerization	IGI Inferred from Genetic Interaction more info	PubMed
potassium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
endosome	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 1B

Names: cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor p27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009875.4 → NP_034005.2 cyclin-dependent kinase inhibitor 1B

Status: VALIDATED

Source sequence(s)

AC122193, U10440

Consensus CDS

CCDS20642.1

UniProtKB/Swiss-Prot

P46414

Related

ENSMUSP00000003115, OTTMUSP00000023377, ENSMUST00000003115, OTTMUST00000050154

Conserved Domains (1) summary

pfam02234
Location:30 – 80
Blast Score: 204

CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38.p1 C57BL/6J

Range

134920401..134925525

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

137877174..137882301

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01058041.1 (16907..22034)	None
genomic	AB083337.1	None	129/SvJ
genomic	AC122193.5 (129429..134553)	None
genomic	CH466572.1	EDL10534.1	mixed
		EDL10535.1	mixed
genomic	U51681.1	None
genomic	U77915.1	None
mRNA	AK046676.1	BAC32833.1	C57BL/6J
mRNA	AK047669.1	BAC33119.1	C57BL/6J
mRNA	AK050240.1	BAC34141.1	C57BL/6J
mRNA	AK154276.1	BAE32483.1	NOD
mRNA	AK158411.1	BAE34494.1	C57BL/6J
mRNA	AK162146.1	None	C57BL/6J
mRNA	AK169586.1	BAE41243.1	C57BL/6J
mRNA	BC014296.1	AAH14296.1	FVB/N
mRNA	CT010382.1	CAJ18589.1
mRNA	U09968.1	AAA20235.1
mRNA	U10440.1	AAA21149.1