Cdk7 cyclin-dependent kinase 7 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cdk7provided by MGI
Official Full Name: cyclin-dependent kinase 7provided by MGI
Primary source: MGI:102956
See related: Ensembl:ENSMUSG00000069089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crk4; Cdkn7; AI323415; AI528512; C230069N13

Genomic context

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Location :: 13 D1; 13 53.23 cM

Sequence :: Chromosome: 13; NC_000079.6 (100697024..100730942, complement)

See Cdk7 in Epigenomics, MapViewer

Chromosome 13 - NC_000079.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Whereas Cdk7 was completely dispensable for global transcription, it was essential for the cell cycle via phosphorylation of Cdk1 and Cdk2. In vivo, Cdk7 was indispensable for cell proliferation except during the first stages of embryonic development.
Title: Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Title: Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
Inhibition of SF-1-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1.
Title: SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.
results demonstrate that the Cdk7 submodule of transcription factor IIH acts as a physiological roadblock to adipogenesis by inhibiting PPARgamma activity
Title: Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.
Cdk7 kinase activity and cell cycle kinetics were found to be comparable in wild-type and Hint(-/-) mouse embryonic fibroblasts, suggesting that Hint may not be a key regulator of Cdk7 activity
Title: The histidine triad protein Hint is not required for murine development or Cdk7 function.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:198650	BioGRID:207616	Atf7ip	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198650	BioGRID:211635	Ccnh	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198650	BioGRID:202321	Ppargc1a	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
Cell cycle signaling pathway, organism-specific biosystem
Cell cycle signaling pathway
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
Cyclin D associated events in G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
Cyclin E associated events during G1/S transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in GG-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in TC-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
Formation of RNA Pol II elongation complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of incision complex in GG-NER, organism-specific biosystem (from REACTOME)
Formation of incision complex in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
Formation of the Early Elongation Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem (from REACTOME)
Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1 Phase, organism-specific biosystem (from REACTOME)
G1 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genomic NER (GG-NER), organism-specific biosystem (from REACTOME)
Global Genomic NER (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Holo-TFIIH complex, organism-specific biosystem (from KEGG)
Holo-TFIIH complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystem (from REACTOME)
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Chain Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase I Chain Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase I Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase I Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Transcription Termination, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription Termination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase II Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcription-coupled NER (TC-NER), organism-specific biosystem (from REACTOME)
Transcription-coupled NER (TC-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
estrogen signalling, organism-specific biosystem (from WikiPathways)
estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
mRNA Capping, organism-specific biosystem (from REACTOME)
mRNA Capping, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH136184 (e-PCR)
- UniSTS:210179

NoName (e-PCR)
- UniSTS:494611

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI323415 (e-PCR)
- UniSTS:180590

RH136039 (e-PCR)
- UniSTS:210034

NoName (e-PCR)
- UniSTS:490683

Homology

Homologs of the Cdk7 gene: The Cdk7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and A.thaliana.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
DNA-dependent ATPase activity	ISO Inferred from Sequence Orthology more info
RNA polymerase II carboxy-terminal domain kinase activity	ISO Inferred from Sequence Orthology more info
cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
kinase activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	ISO Inferred from Sequence Orthology more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA repair	IEA Inferred from Electronic Annotation more info
cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cell division	IEA Inferred from Electronic Annotation more info
phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
holo TFIIH complex	ISO Inferred from Sequence Orthology more info
membrane	ISO Inferred from Sequence Orthology more info
mitochondrion	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase 7

Names: cyclin-dependent kinase 7; CAK; P39 Mo15; CR4 protein kinase; 39 kDa protein kinase; CDK-activating kinase; protein-tyrosine kinase MPK-7; cell division protein kinase 7; CRK4 PK (CDC2-related-kinase-4 protein kinase); TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)

NP_034004.2

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009874.3 → NP_034004.2 cyclin-dependent kinase 7

Status: VALIDATED

Source sequence(s)

AC165159, AW120870, BC068160, CJ111227

Consensus CDS

CCDS36766.1

UniProtKB/Swiss-Prot

Q03147

UniProtKB/TrEMBL

Q3THG5

Related

ENSMUSP00000088845, ENSMUST00000091299

Conserved Domains (2) summary

cd07841
Location:11 – 308
Blast Score: 1558

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

PTZ00024
Location:7 – 308
Blast Score: 792

PTZ00024; cyclin-dependent protein kinase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000079.6 Reference GRCm38.p1 C57BL/6J

Range

100697024..100730942, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000035.1 Alternate Mm_Celera

Range

104306673..104340748, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01109421.1	None
genomic	AAHY01109422.1	None
genomic	AAHY01109423.1	None
genomic	AAHY01109424.1 (6018..11360)	None
genomic	AC165159.2 (154345..188016)	None
genomic	CH466567.2	EDL00796.1	mixed
		EDL00797.1	mixed
mRNA	AK039084.1	BAC30233.1	C57BL/6J
mRNA	AK082618.1	None	C57BL/6J
mRNA	AK145759.1	BAE26631.1	C57BL/6J
mRNA	AK146316.1	BAE27071.1	BALB/c
mRNA	AK164567.1	None	C57BL/6J
mRNA	AK168286.1	BAE40231.1	DBA/2
mRNA	AW120870.1	None	C57BL/6J
mRNA	BC004605.1	AAH04605.1	FVB/N
mRNA	BC068160.1	AAH68160.1	C57BL/6
mRNA	BC141043.1	AAI41044.1
mRNA	CJ111227.1	None	C57BL/6J
mRNA	U11822.1	AAA64831.1
mRNA	X57239.1	CAA40515.1
mRNA	X65070.1	CAA46203.1	CBA
mRNA	X74145.1	CAA52242.1	CBA