Format

Send to:

Choose Destination

Cdh5 cadherin 5 [ Mus musculus (house mouse) ]

Gene ID: 12562, updated on 8-May-2016
Official Symbol
Cdh5provided by MGI
Official Full Name
cadherin 5provided by MGI
Primary source
MGI:MGI:105057
See related
Ensembl:ENSMUSG00000031871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
7B4; Vec; VECD; Cd144; VEcad; VE-Cad; AA408225
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein die in utero due to vascular insufficiency, caused by increased endothelial apoptosis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]
Orthologs
Location:
8 D3; 8 53.04 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (104101613..104144504)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (106625525..106668402)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39236 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene, 29682 Neighboring gene brain expressed, associated with Nedd4, 1 Neighboring gene thymidine kinase 2, mitochondrial

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
blood vessel maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
single organismal cell-cell adhesion IC
Inferred by Curator
more info
PubMed 
single organismal cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cadherin-5
Names
7B4/cadherin-5
VE-cadherin
vascular endothelial cadherin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009868.4NP_033998.2  cadherin-5 preproprotein

    See identical proteins and their annotated locations for NP_033998.2

    Status: REVIEWED

    Source sequence(s)
    BC054790, BP768525, BY078746
    Consensus CDS
    CCDS22572.1
    UniProtKB/Swiss-Prot
    P55284
    Related
    ENSMUSP00000034339, ENSMUST00000034339
    Conserved Domains (2) summary
    cd11304
    Location:153252
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:637777
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    104101613..104144504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530630.1XP_006530693.1  

    See identical proteins and their annotated locations for XP_006530693.1

    UniProtKB/Swiss-Prot
    P55284
    Conserved Domains (2) summary
    cd11304
    Location:153252
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:637777
    Cadherin_C; Cadherin cytoplasmic region

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    108332486..108375834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)