Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    Cdh1 cadherin 1 [ Mus musculus (house mouse) ]

    Gene ID: 12550, updated on 11-May-2013
    Official Symbol
    Cdh1provided by MGI
    Official Full Name
    cadherin 1provided by MGI
    Primary source
    MGI:88354
    See related
    Ensembl:ENSMUSG00000000303; Vega:OTTMUSG00000020588
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Um; UVO; Ecad; E-cad; L-CAM; AA960649
    Location :
    8 D; 8 53.18 cM
    Sequence :
    Chromosome: 8; NC_000074.6 (106603368..106670246)
    See Cdh1 in Epigenomics, MapViewer

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110028F18 gene Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene predicted gene, 20254 Neighboring gene transport and golgi organization 6 Neighboring gene hyaluronan synthase 3

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NC_000074.1 NP_035676.1 Zeb1    BIND  PubMed Zfhx1a (deltaEF1) interacts with the Cdh1 (E-cadherin) promoter. 
    BioGRID:198631 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:198631 BioGRID:198512 Ctnnb1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:198631 BioGRID:199259 Dnmt1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198631 BioGRID:199963 Gna13    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198631 BioGRID:109931 JUP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198631 BioGRID:202162 Pik3r1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198631 BioGRID:202414 Psen1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198631 BioGRID:231884 Ptprq    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Homology

    Clone Names

    • MGC107495

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
     
    cellular response to indole-3-methanol ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cochlea development IMP
    Inferred from Mutant Phenotype
    more info
     
    homophilic cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription factor import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of water loss via skin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    salivary gland cavitation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
     
    synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Schmidt-Lanterman incisure IDA
    Inferred from Direct Assay
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    apical junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    internal side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lateral loop IDA
    Inferred from Direct Assay
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    node of Ranvier IDA
    Inferred from Direct Assay
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cadherin-1
    Names
    cadherin-1
    ARC-1
    E-cadherin
    uvomorulin
    epithelial cadherin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009864.2NP_033994.1  cadherin-1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC132132, AC147500
      Consensus CDS
      CCDS22638.1
      UniProtKB/Swiss-Prot
      P09803
      Related
      ENSMUSP00000000312, OTTMUSP00000022465, ENSMUST00000000312, OTTMUST00000048788
      Conserved Domains (5) summary
      pfam08758
      Location:29118
      Blast Score: 323
      Cadherin_pro; Cadherin prodomain like
      pfam01049
      Location:734881
      Blast Score: 297
      Cadherin_C; Cadherin cytoplasmic region
      pfam00028
      Location:606688
      Blast Score: 132
      Cadherin; Cadherin domain
      cd00031
      Location:160260
      Blast Score: 348
      CA_like; Cadherin repeat-like domain.
      cd11304
      Location:268373
      Blast Score: 263
      Cadherin_repeat; Cadherin tandem repeat domain.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p1 C57BL/6J

      Range
      106603368..106670246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000030.1 Alternate Mm_Celera

      Range
      110827793..110895640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...