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    INO80C INO80 complex subunit C [ Homo sapiens ]

    Gene ID: 125476, updated on 11-May-2012
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    Summary

    Official Symbol
    INO80Cprovided by HGNC
    Official Full Name
    INO80 complex subunit Cprovided by HGNC
    Primary source
    HGNC:26994
    See related
    Ensembl:ENSG00000153391; HPRD:10719; Vega:OTTHUMG00000132564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IES6; hIes6; C18orf37; FLJ38183
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    Genomic context

    Location :
    18q12.2
    Sequence :
    Chromosome: 18; NC_000018.9 (33048291..33077955, complement)
    See INO80C in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene zinc finger protein 396 Neighboring gene ribosomal protein L7a pseudogene 67 Neighboring gene microRNA 3975 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. YY1 functions with INO80 to activate transcription. Cai Y, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17721549.
    4. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Denis NJ, et al. Proteomics, 2007 Mar. PMID 17370265.
    5. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. Choy KW, et al. Physiol Genomics, 2006 Mar 13. PMID 16368877.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. C18orf37, similar in sequence to yeast Ies6p. A subunit of the Ino80 chromatin remodeling complex, which has roles in transcription and DNA repair.
      Title: A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q6PI98 P21673 SAT1    HPRD  PubMed  
    BioGRID:125928 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:122993 ACTR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:125062 ACTR8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:109269 H2AFZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:120076 INO80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:123646 INO80B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:125928 INO80C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:120238 INO80D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:129701 INO80E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:110864 NFRKB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:125928 BioGRID:118931 TFPT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125928 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-MS; Co-localization 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    biological_process ND
    No biological Data available
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		  
    MLL1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    INO80 complex subunit C
    Names
    INO80 complex subunit C
    IES6 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098817.1 → NP_001092287.1  INO80 complex subunit C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BF475320, BM758571, BQ887287, BY800049, EC520842
      Consensus CDS
      CCDS45853.1
      UniProtKB/TrEMBL
      E9PCS7
      Related
      ENSP00000391457, ENST00000441607
      Conserved Domains (1) summary
      cl02154
      Location:136 – 223
      Blast Score: 178
      YL1_C; YL1 nuclear protein C-terminal domain

    2. NM_194281.3 → NP_919257.2  INO80 complex subunit C isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BF475320, BQ887287, EC520842
      Consensus CDS
      CCDS11914.1
      UniProtKB/Swiss-Prot
      Q6PI98
      Related
      ENSP00000334473, OTTHUMP00000163382, ENST00000334598, OTTHUMT00000255768
      Conserved Domains (1) summary
      cl02154
      Location:100 – 187
      Blast Score: 181
      YL1_C; YL1 nuclear protein C-terminal domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      33048291..33077955, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      29908353..29937720, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC007998.10 (130808..160466) None
    genomic CH471088.1 EAX01357.1
      EAX01358.1
    mRNA AK095502.1 BAC04560.1
    mRNA AK300660.1 BAG62346.1
    mRNA BC039404.1 AAH39404.1
    mRNA BC048989.1 None
    mRNA BF475320.1 None
    mRNA BM758571.1 None
    mRNA BQ887287.1 None
    mRNA BY800049.1 None
    mRNA EC520842.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PI98.1 GenPept UniProtKB/Swiss-Prot:Q6PI98
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Molecular Biology Databases
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