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sptP protein tyrosine phosphate [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1254401, updated on 4-Feb-2024

Summary

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Gene symbol
sptP
Gene description
protein tyrosine phosphate
Locus tag
STM2878
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Genomic context

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Sequence:
NC_003197.2 (3022078..3023717, complement)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene invasion genes transcription activator Neighboring gene cell invasion protein Neighboring gene chaparone related to virulence Neighboring gene putative cytoplasmic protein Neighboring gene putative acyl carrier protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP. Choi HW, et al. Immunity, 2013 Dec 12. PMID 24332031, Free PMC Article
  2. SptP106-136 plays a role in the complex formation with SptP-specific chaperone SicP. Hayashi F, et al. Biosci Biotechnol Biochem, 2014. PMID 25209503
  3. Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system. Button JE, et al. Mol Microbiol, 2011 Sep. PMID 21801239, Free PMC Article
  4. The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche. Humphreys D, et al. Cell Host Microbe, 2009 Mar 19. PMID 19286132, Free PMC Article
  5. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. McClelland M, et al. Nature, 2001 Oct 25. PMID 11677609

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we suggest the possibility that residues 106-136 of SptP are important for complex formation with SicP by in vitro reconstitution experiments.
    Title: SptP106-136 plays a role in the complex formation with SptP-specific chaperone SicP.
  2. SptP functioned by dephosphorylating the vesicle fusion protein N-ethylmalemide-sensitive factor and by blocking phosphorylation of Syk
    Title: Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP.
  3. Translation of the effector sptP is coupled to that of its chaperone sicP, and in the absence of translational coupling, an inhibitory RNA structure prevents translation of sptP.
    Title: Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system.
  4. Direct SptP binding and specific dephosphorylation of the AAA+ ATPase valosin-containing protein (VCP/p97), a facilitator of cellular membrane fusion and protein degradation, enhanced pathogen replication in Salmonella-containing vacuoles.
    Title: The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche.
Submit: New GeneRIF Correction

General gene information

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regulatory

  • Loc: c3023717-3023712 regulatory_class = ribosome_binding_site

General protein information

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Preferred Names
protein tyrosine phosphate
NP_461799.1
  • protein tyrosine phosphatase SptP (gi|1519054)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    3022078..3023717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_461799.1 protein tyrosine phosphate [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_461799.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5X0ZJ68, A0A5X1Q8Y3, A0A605QNC2, A0A611V783, A0A701EE28, A0A703WJN8, A0A730T3Q2, A0A740FCD3, A0A740WXR6, A0A756GBS0, A0A764NTE8, A0A764Q7X3
    Conserved Domains (1) summary
    PRK15375
    Location:9 → 543
    PRK15375; type III secretion system effector GTPase-activating protein SptP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P74873.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases