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    Cdc42 cell division cycle 42 homolog (S. cerevisiae) [ Mus musculus ]

    Gene ID: 12540, updated on 20-May-2012
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    Summary

    Official Symbol
    Cdc42provided by MGI
    Official Full Name
    cell division cycle 42 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:106211
    Locus tag
    RP23-246F18.2
    See related
    Ensembl:ENSMUSG00000006699; Vega:OTTMUSG00000009829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI747189; AU018915
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    Genomic context

    Location :
    4 D3; 4 66.75 cM
    Sequence :
    Chromosome: 4; NC_000070.6 (137319696..137357759, complement)
    See Cdc42 in Epigenomics, MapViewer

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene chromobox homolog 5 pseudogene Neighboring gene wingless-related MMTV integration site 4 Neighboring gene ribosomal protein L31, pseudogene 10 Neighboring gene predicted gene 13011

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. Sakamori R, et al. J Clin Invest, 2012 Mar 1. PMID 22354172.
    2. Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Heynen SR, et al. Mol Vis, 2011. PMID 22128240.
    3. The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages. Rosales-Reyes R, et al. Cell Microbiol, 2012 Feb. PMID 22023353.
    4. Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. Roney KE, et al. PLoS One, 2011. PMID 21966369.
    5. The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination. Yamauchi J, et al. J Neurosci, 2011 Aug 31. PMID 21880919.

    See all (231) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The authors show that intracellular Burkholderia cenocepacia expressing a type VI secretion system (T6SS) affects the activation of the Rac1 and Cdc42 RhoGTPase by reducing the cellular pool of GTP-bound Rac1 and Cdc42.
      Title: The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages.
    2. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice
      Title: Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
    3. Data show that Plexin-B2 functions in macrophages as a negative regulator of the GTPases Rac and Cdc42 and as a negative
      Title: Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation.
    4. Glucose stimulates Cav-1 and induces its dissociation from Cdc42, to promote Cdc42-betaPix binding and Cdc42 activation, and to trigger downstream signaling and ultimately sustain insulin release.
      Title: Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.
    5. The cell migration is dependent on the continuous organization of the actin cytoskeleton, which is regulated by Cdc42.
      Title: Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis.
    6. Cdc42 controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption.
      Title: The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
    7. Cdc42 regulates extracellular matrix remodeling in three dimensions.
      Title: Cdc42 regulates extracellular matrix remodeling in three dimensions.
    8. Cdc42 is required for platelet filopodia formation, secretion and aggregation and therefore plays a critical role in platelet mediated hemostasis and thrombosis.
      Title: Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.
    9. These data suggest that impaired recruitment of astrocytes to sites of injury has a profound and unexpected effect on microglia recruitment.
      Title: Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo.
    10. PKCiota and GSK-3beta are downstream effectors of Cdc42 during vascular morphogenesis.
      Title: Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis.
    Submit: New GeneRIF Correction See all (106)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAB40051.1 CAC39270.1     BIND  PubMed YopT cleaves Cdc42 amino-terminal to prenylated Cys188. This interaction was modeled on a demonstrated interaction between Yersinia pseudotuberculosis YopT and Cdc42 from an unspecified species. 
    NP_033991.1 NP_570932.1 Baiap2    BIND  PubMed Cdc42 interacts with IRSp53. This interaction was modeled on a demonstrated interaction between Cdc42 from an unspecified species and mouse IRSp53. 
    NP_033991.1 NP_081495.1 Cdc42ep1    BIND  PubMed Activated Cdc42 interacts with Borg5. This interaction was modeled on a demonstrated interaction between Cdc42 from an unknown species and Borg5 from mouse. 
    NP_033991.1 NP_064390.1 Cdc42ep4    BIND  PubMed Activated Cdc42 interacts with Borg4. This interaction was modeled on a demonstrated interaction between Cdc42 from an unknown species and Borg4 from mouse. 
    NP_033991.1 NP_067429.1 Cdc42ep5    BIND  PubMed Activated Cdc42 interacts with Borg3. This interaction was modeled on a demonstrated interaction between Cdc42 from an unspecified species and Borg3 from mouse. 
    NP_033991.1 AAQ82539.1 Diap2    BIND  PubMed mDia3 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between mDia3 from mouse and Cdc42 from an unspecified species. 
    NP_033991.1 NP_035165.1 Pak1    BIND  PubMed Cdc42 interacts with PAK1. This interaction was modeled on a demonstrated interaction between mouse Cdc42 and PAK1 from an unspecified species. 
    NP_033991.1 NP_032804.1 Pak3    BIND  PubMed Pak3 interacts with Cdc42. This interaction was modeled on a demonstrated interaction between mouse Pak3 and human Cdc42. 
    NP_033991.1     BIND  PubMed Cdc42 interacts with GTP. This interaction was modelled on a demonstrated interaction between human Cdc42 and GTP. 
    BioGRID:198627 BioGRID:237045 Arhgap32    BioGRID  PubMed Biochemical Activity 
    BioGRID:198627 BioGRID:110928 NPHS1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:198627 BioGRID:202020 Pak1    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the Cdc42 gene: The Cdc42 gene is conserved in human, chimpanzee, , dog, cow, rat, chicken, zebrafish, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.
    • Map Viewer (Human, Rat)

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
      CD28 dependent Vav1 pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • CDO in myogenesis, organism-specific biosystem (from REACTOME)
      CDO in myogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • DCC mediated attractive signaling, organism-specific biosystem (from REACTOME)
      DCC mediated attractive signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Inactivation of Cdc42 and Rac, organism-specific biosystem (from REACTOME)
      Inactivation of Cdc42 and Rac, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Myogenesis, organism-specific biosystem (from REACTOME)
      Myogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • p38 MAPK Signaling Pathway (BioCarta), organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway (BioCarta), organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    canonical Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    endosome transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    epithelial-mesenchymal cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment or maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    filopodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    hair follicle placode formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    keratinization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    keratinocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nucleus localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell cycle cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of hair follicle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    intracellular TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    cell division control protein 42 homolog
    Names
    cell division control protein 42 homolog
    G25K GTP-binding protein
    NP_001230698.1
    NP_033991.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243769.1 → NP_001230698.1  cell division control protein 42 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which is the same length but has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL645468, BF467211, CD353254, CD551112, L78075
      UniProtKB/Swiss-Prot
      P60766
      Conserved Domains (1) summary
      cd01874
      Location:3 – 177
      Blast Score: 947
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    2. NM_009861.3 → NP_033991.1  cell division control protein 42 homolog isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AK168758, AL645468, BE685696, CD551112
      Consensus CDS
      CCDS18816.1
      UniProtKB/Swiss-Prot
      P60766
      Related
      ENSMUSP00000054634, OTTMUSP00000010388, ENSMUST00000051477, OTTMUST00000022761
      Conserved Domains (1) summary
      cd01874
      Location:3 – 177
      Blast Score: 949
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38 C57BL/6J

      Range
      137319696..137357759, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000026.1 Alternate Mm_Celera

      Range
      135540002..135577876, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL645468.11 CAM18513.1
      CAM18514.1
    genomic CH466552.2 EDL29921.1 mixed
    mRNA AK003098.1 BAB22563.1 C57BL/6J
    mRNA AK051543.1 BAC34669.1 C57BL/6J
    mRNA AK075567.1 BAC35825.1 C57BL/6J
    mRNA AK081384.1 None C57BL/6J
    mRNA AK144216.1 BAE25778.1
    mRNA AK145659.1 BAE26572.1 C57BL/6J
    mRNA AK150563.1 None C57BL/6J
    mRNA AK151087.1 BAE30100.1 C57BL/6J
    mRNA AK151726.1 BAE30644.1 C57BL/6J
    mRNA AK153564.1 BAE32098.1 C57BL/6J
    mRNA AK154870.1 BAE32891.1 NOD
    mRNA AK159470.1 BAE35111.1 C57BL/6J
    mRNA AK166281.1 BAE38678.1
    mRNA AK167195.1 BAE39325.1 C57BL/6J
    mRNA AK167400.1 BAE39489.1 C57BL/6J
    mRNA AK167609.1 BAE39663.1 C57BL/6J
    mRNA AK168013.1 BAE40000.1 DBA/2
    mRNA AK168076.1 BAE40049.1 BALB/c
    mRNA AK168089.1 BAE40062.1 DBA/2
    mRNA AK168276.1 BAE40222.1 BALB/c
    mRNA AK168503.1 None C57BL/6J
    mRNA AK168758.1 BAE40595.1 C57BL/6J
    mRNA AK168820.1 BAE40647.1 C57BL/6J
    mRNA AK169122.1 BAE40902.1 C57BL/6J
    mRNA AK169232.1 BAE41001.1 C57BL/6J
    mRNA AK169805.1 BAE41379.1 NOD
    mRNA AK181967.1 None
    mRNA AK183308.1 None
    mRNA AK208829.1 None
    mRNA AK211726.1 None
    mRNA AK213611.1 None
    mRNA AK214706.1 None
    mRNA AK218916.1 None
    mRNA BC064792.1 AAH64792.1 C57BL/6J
    mRNA BE685696.1 None C57BL/6J
    mRNA BF467211.1 None C57BL/6J
    mRNA CD353254.1 None C57BL/6
    mRNA CD551112.1 None C57BL/6J
    mRNA L11318.1 AAA37410.1
    mRNA L78075.1 AAB40051.1 C57BL/6
    mRNA M79301.1 AAK14822.1
    mRNA U37720.1 AAC00028.1
    mRNA U76960.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60766.2 GenPept UniProtKB/Swiss-Prot:P60766
    Q3UL78 GenPept UniProtKB/TrEMBL:Q3UL78
    Q99JI7 GenPept UniProtKB/TrEMBL:Q99JI7
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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