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Cdc25c cell division cycle 25C [ Mus musculus (house mouse) ]

Gene ID: 12532, updated on 8-May-2016
Official Symbol
Cdc25cprovided by MGI
Official Full Name
cell division cycle 25Cprovided by MGI
Primary source
MGI:MGI:88350
See related
Ensembl:ENSMUSG00000044201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc25
Summary
This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014]
Orthologs
Location:
18 B1; 18 18.71 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (34732993..34752130, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34892651..34911187, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 20A Neighboring gene CDC23 cell division cycle 23 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene RIKEN cDNA 2010110K18 gene Neighboring gene family with sequence similarity 53, member C

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
WW domain binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic M phase IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
M-phase inducer phosphatase 3
Names
cell cycle phosphatase CDC25C
cell division cycle control protein 25C
dual specificity phosphatase Cdc25C
NP_033990.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009860.3NP_033990.2  M-phase inducer phosphatase 3

    See identical proteins and their annotated locations for NP_033990.2

    Status: REVIEWED

    Source sequence(s)
    AC145591, AK141737
    Consensus CDS
    CCDS37759.1
    UniProtKB/Swiss-Prot
    P48967
    UniProtKB/TrEMBL
    Q3UR74
    Related
    ENSMUSP00000055427, ENSMUST00000060710
    Conserved Domains (2) summary
    cd01530
    Location:275394
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:98218
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    34732993..34752130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525550.2XP_006525613.1  

    See identical proteins and their annotated locations for XP_006525613.1

    UniProtKB/Swiss-Prot
    P48967
    UniProtKB/TrEMBL
    Q3UR74
    Conserved Domains (2) summary
    cd01530
    Location:275394
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:98218
    M-inducer_phosp; M-phase inducer phosphatase
  2. XM_006525551.2XP_006525614.1  

    Conserved Domains (2) summary
    cd01530
    Location:200319
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:98159
    M-inducer_phosp; M-phase inducer phosphatase
  3. XM_011246819.1XP_011245121.1  

    Conserved Domains (1) summary
    cd01530
    Location:89208
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    35187371..35205655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)