Format

Send to:

Choose Destination

Cd8a CD8 antigen, alpha chain [ Mus musculus (house mouse) ]

Gene ID: 12525, updated on 28-May-2016
Official Symbol
Cd8aprovided by MGI
Official Full Name
CD8 antigen, alpha chainprovided by MGI
Primary source
MGI:MGI:88346
See related
Ensembl:ENSMUSG00000053977 Vega:OTTMUSG00000057913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-2; Ly-B; Ly-35; Lyt-2; BB154331
Orthologs
Location:
6 32.14 cM; 6 C
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (71352772..71379171)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (71323421..71329165)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38828 Neighboring gene CD8 antigen, beta chain 1 Neighboring gene predicted gene, 38829 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene predicted gene, 30582

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (13)  1 citation

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell activation ISO
Inferred from Sequence Orthology
more info
 
T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytotoxic T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
T-cell surface glycoprotein CD8 alpha chain
Names
Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
T-cell surface glycoprotein Lyt-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081110.2NP_001074579.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001074579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC160090
    Consensus CDS
    CCDS39507.1
    UniProtKB/Swiss-Prot
    P01731
    Related
    ENSMUSP00000068123, OTTMUSP00000074222, ENSMUST00000066747, OTTMUST00000142196
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like
  2. NM_009857.1NP_033987.1  T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_033987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region resulting in a frameshift, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC160090
    Consensus CDS
    CCDS51806.1
    UniProtKB/TrEMBL
    Q8CAX3
    Related
    ENSMUSP00000131873, OTTMUSP00000074223, ENSMUST00000172321, OTTMUST00000142198
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    71352772..71379171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505464.2XP_006505527.1  

    See identical proteins and their annotated locations for XP_006505527.1

    UniProtKB/Swiss-Prot
    P01731
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like
  2. XM_006505465.2XP_006505528.1  

    See identical proteins and their annotated locations for XP_006505528.1

    UniProtKB/TrEMBL
    Q8CAX3
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    73452794..73458537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)