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Cd84 CD84 antigen [ Mus musculus (house mouse) ]

Gene ID: 12523, updated on 8-May-2016
Official Symbol
Cd84provided by MGI
Official Full Name
CD84 antigenprovided by MGI
Primary source
MGI:MGI:1336885
See related
Ensembl:ENSMUSG00000038147 Vega:OTTMUSG00000026928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDw84; SLAMF5; A130013D22Rik
Orthologs
Location:
1 H3; 1 79.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (171839697..171890718)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173770710..173820849)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene signaling lymphocytic activation molecule family member 1 Neighboring gene predicted gene, 37065 Neighboring gene SLAM family member 6 Neighboring gene vang-like 2 (van gogh, Drosophila)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-10 secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-18 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor secretion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SLAM family member 5
Names
leukocyte differentiation antigen CD84
signaling lymphocytic activation molecule 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252472.1NP_001239401.1  SLAM family member 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC091523, BY207887
    Consensus CDS
    CCDS56657.1
    UniProtKB/Swiss-Prot
    Q18PI6
    UniProtKB/TrEMBL
    A0A0R4J1S4
    Related
    ENSMUSP00000115674, OTTMUSP00000033389, ENSMUST00000135386, OTTMUST00000066581
    Conserved Domains (1) summary
    cd05775
    Location:31126
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
  2. NM_001289470.1NP_001276399.1  SLAM family member 5 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AC091523, BY207887
    Consensus CDS
    CCDS69979.1
    UniProtKB/TrEMBL
    E9Q9E8
    Related
    ENSMUSP00000122951, OTTMUSP00000033390, ENSMUST00000136479, OTTMUST00000066582
    Conserved Domains (2) summary
    cd05775
    Location:31126
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    pfam13927
    Location:131194
    Ig_3; Immunoglobulin domain
  3. NM_013489.3NP_038517.1  SLAM family member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_038517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC091523, BY207887
    Consensus CDS
    CCDS15503.1
    UniProtKB/Swiss-Prot
    Q18PI6
    UniProtKB/TrEMBL
    A0A0R4J0K5
    Related
    ENSMUSP00000120881, OTTMUSP00000033388, ENSMUST00000155802, OTTMUST00000066580
    Conserved Domains (2) summary
    cd05775
    Location:31126
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    pfam13927
    Location:131194
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    171839697..171890718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496639.2XP_006496702.1  

    Conserved Domains (1) summary
    pfam13927
    Location:1073
    Ig_3; Immunoglobulin domain
  2. XM_011238747.1XP_011237049.1  

    Conserved Domains (1) summary
    pfam13927
    Location:2083
    Ig_3; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    174695682..174739215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)