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    Cd80 CD80 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12519, updated on 11-May-2013
    Official Symbol
    Cd80provided by MGI
    Official Full Name
    CD80 antigenprovided by MGI
    Primary source
    MGI:101775
    See related
    Ensembl:ENSMUSG00000075122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B71; Ly53; TSA1; Cd28l; Ly-53; MIC17
    Location :
    16 B5; 16 26.86 cM
    Sequence :
    Chromosome: 16; NC_000082.6 (38458933..38486933)
    See Cd80 in Epigenomics, MapViewer

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene phospholipase A1 member A Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene creatine kinase pseudogene 3 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 pseudogene Neighboring gene protein O-glucosyltransferase 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Mcl-1 is essential for the survival of plasma cells. Peperzak V, et al. Nat Immunol, 2013 Mar. PMID 23377201.
    2. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Liu B, et al. Development, 2013 Feb. PMID 23362346.
    3. Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand. Corse E, et al. J Immunol, 2013 Jan 15. PMID 23248264.
    4. Three-dimensional visualization of the mouse thymus organization in health and immunodeficiency. Irla M, et al. J Immunol, 2013 Jan 15. PMID 23248258.
    5. CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination. Sokke Umeshappa C, et al. PLoS One, 2012. PMID 23071696.

    See all (295) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Although CD70 is required for dendritic cell-mediated delay of T cell tolerance induction, CD80 and CD86 are necessary for refunctionalizing the tolerized T cells in prostate tumor tissue
      Title: Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.
    2. These data demonstrate, for the first time, that iTregs can acquire CD80 and CD86 from mDCs, and the acquisition of CD86 may enhance their suppressive function.
      Title: Trogocytosis of CD80 and CD86 by induced regulatory T cells.
    3. Mixed bone marrow chimeras demonstrated a B cell-intrinsic requirement for CD80 expression for normal T(FH) cell and PC development
      Title: CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation.
    4. Under influence of estrogen, expression of CD80 appears to be down-regulated during activation of B cells; that is, upon addition of 17beta-estradiol to cultured splenocytes, CD80 is down-regulated but IgG is up-regulated.
      Title: Estrogen promotes B cell activation in vitro through down-regulating CD80 molecule expression.
    5. B7-1 interactions with programmed death-1 ligand 1 (PD-L1) may be particularly important for regulating potentially pathogenic self-reactive effector T cells.
      Title: The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo.
    6. B7-CD28 costimulation differentially regulates the magnitude and kinetics of the multifaceted CD8 T cell response that develops during muromegalovirus infection.
      Title: Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.
    7. B7-1 on stromal cells is a key molecule regulating IL-10 production by multifunctional Treg cells, HOZOT.
      Title: Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line.
    8. Mice inoculated with H22 tumor cells expressing B7-1, B7-2 and 4-1BBL developed a strong cytotoxic T lymphocyte response and long-term immunity against wild-type tumor, suggesting a synergistic effect between the B7 and 4-1BBL costimulatory pathways
      Title: Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma.
    9. A new immune regulation loop is revealed consisting of T cell-derived interferon-gamma, B7H1 expression by antigen-presenting cells, and B7.1 expression by regulatory T (Treg) cells in an autoimmune-like graft-versus-host disease model.
      Title: Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients.
    10. study shows CTLA-4 can capture its ligands (CD80, CD86)from opposing cells by trans-endocytosis; data reveal mechanism of immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by cell-extrinsic depletion of ligands
      Title: Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
    Submit: New GeneRIF Correction See all (107)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    T-lymphocyte activation antigen CD80
    B7 protein
    activation B7-1 antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009855.2 → NP_033985.3  T-lymphocyte activation antigen CD80 precursor

      Status: VALIDATED

      Source sequence(s)
      AC154425, X60958
      Consensus CDS
      CCDS28168.1
      UniProtKB/Swiss-Prot
      Q00609
      UniProtKB/TrEMBL
      Q549R2
      Related
      ENSMUSP00000097404, ENSMUST00000099816
      Conserved Domains (3) summary
      cd00098
      Location:157 – 235
      Blast Score: 124
      IgC; Immunoglobulin Constant domain
      pfam07686
      Location:42 – 130
      Blast Score: 116
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:49 – 121
      Blast Score: 109
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p1 C57BL/6J

      Range
      38458933..38486933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      38869381..38897547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01127146.1 (57314..68612) None
    genomic AAHY01127147.1 None
    genomic AC154425.2 (160604..160977) None
    genomic AC209577.2 (69200..97200) None
    genomic CH466521.1 EDK97981.1 mixed
      EDK97982.1 mixed
      EDK97983.1 mixed
    genomic CT571259.11 (39613..67615) None
    genomic L12585.1 AAA37240.1
    genomic L12586.1 AAA37240.1
    genomic L12587.1 AAA37240.1
    genomic L12588.1 AAA37240.1
    genomic L12589.1 AAA37240.1
    genomic S74540.1 AAB32535.2 129/Sv
    genomic S74541.1 AAB32536.2 129/Sv
    genomic S74695.1 AAB32537.2 129/Sv
    genomic S74696.1 AAB32537.2 129/Sv
    genomic U26832.1 None
    genomic U33063.1 None
    mRNA AF065893.1 AAD25876.1 A/J
    mRNA AF065894.1 AAD25877.1 C57BL/6J
    mRNA AF065895.1 AAD25878.1 B10.S/J
    mRNA AF065896.1 AAD25879.1 SJL/J
    mRNA AJ278965.1 CAC34306.1
    mRNA AK019867.1 None C57BL/6J
    mRNA AK154329.1 BAE32518.1 NOD
    mRNA AY278186.1 AAP57303.1
    mRNA BC131959.1 AAI31960.1
    mRNA BC145843.1 AAI45844.1
    mRNA D16220.1 BAA03748.1 C57BL/6CrSlc
    mRNA X60958.1 CAA43291.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00609.1 GenPept UniProtKB/Swiss-Prot:Q00609

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
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        PMC links
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        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
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        Link to related Nucleotide entry
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        Related Probe entry
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        Link to related protein entry
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        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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