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KRT40 keratin 40 [ Homo sapiens (human) ]

Gene ID: 125115, updated on 26-May-2016
Official Symbol
KRT40provided by HGNC
Official Full Name
keratin 40provided by HGNC
Primary source
HGNC:HGNC:26707
See related
Ensembl:ENSG00000204889 HPRD:08304; MIM:616679; Vega:OTTHUMG00000133596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K40; KA36; CK-40
Summary
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
Orthologs
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (40977716..40987139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39133968..39143387, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 23 Neighboring gene keratin 39 Neighboring gene keratin associated protein 3-3 Neighboring gene keratin associated protein 3-2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
keratin, type I cytoskeletal 40
Names
cytokeratin-40
keratin 40, type I
keratin-40
type I hair keratin KA36

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012412.1 RefSeqGene

    Range
    5001..14420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182497.3NP_872303.2  keratin, type I cytoskeletal 40

    See identical proteins and their annotated locations for NP_872303.2

    Status: REVIEWED

    Source sequence(s)
    AC007455, BC150174
    Consensus CDS
    CCDS42320.1
    UniProtKB/Swiss-Prot
    Q6A162
    Related
    ENSP00000381500, OTTHUMP00000164963, ENST00000398486, OTTHUMT00000257701
    Conserved Domains (2) summary
    pfam00038
    Location:88399
    Filament; Intermediate filament protein
    cl21478
    Location:254360
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    40977716..40987139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524338.1XP_011522640.1  

    See identical proteins and their annotated locations for XP_011522640.1

    UniProtKB/Swiss-Prot
    Q6A162
    Conserved Domains (2) summary
    pfam00038
    Location:88399
    Filament; Intermediate filament protein
    cl21478
    Location:254360
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  2. XM_011524339.1XP_011522641.1  

    See identical proteins and their annotated locations for XP_011522641.1

    UniProtKB/TrEMBL
    G3V1C2
    Related
    ENSP00000434458, OTTHUMP00000164962, ENST00000461923, OTTHUMT00000257700
    Conserved Domains (1) summary
    pfam00038
    Location:88229
    Filament; Intermediate filament protein

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    127111..136534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547133.1XP_011545435.1  

    See identical proteins and their annotated locations for XP_011545435.1

    UniProtKB/Swiss-Prot
    Q6A162
    Conserved Domains (2) summary
    pfam00038
    Location:88399
    Filament; Intermediate filament protein
    cl21478
    Location:254360
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  2. XM_011547134.1XP_011545436.1  

    See identical proteins and their annotated locations for XP_011545436.1

    UniProtKB/TrEMBL
    G3V1C2
    Conserved Domains (1) summary
    pfam00038
    Location:88229
    Filament; Intermediate filament protein

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    39369715..39379138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)