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Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 [ Mus musculus (house mouse) ]

Gene ID: 12499, updated on 28-May-2016
Official Symbol
Entpd5provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 5provided by MGI
Primary source
MGI:MGI:1321385
See related
Ensembl:ENSMUSG00000021236 Vega:OTTMUSG00000027582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcph; Cd39l4; mNTPase; AI196558; AI987697; NTPDase5; ER-UDPase; NTPDase-5
Orthologs
Location:
12 39.18 cM; 12 E
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (84373875..84409029, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (85714807..85749979, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene coenzyme Q6 monooxygenase Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase family 6, subfamily A1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
guanosine-diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
uridine-diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
'de novo' posttranslational protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ectonucleoside triphosphate diphosphohydrolase 5
Names
CD39 antigen-like 4
GDPase ENTPD5
NTPDase 5
UDPase ENTPD5
guanosine-diphosphatase ENTPD5
nucleoside diphosphatase
uridine-diphosphatase ENTPD5
NP_001021385.1
NP_001272978.1
NP_001272987.1
NP_031673.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001026214.2NP_001021385.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001021385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
    Source sequence(s)
    AK081435, AK160950, BY049870, CD775710
    Consensus CDS
    CCDS26045.1
    UniProtKB/Swiss-Prot
    Q9WUZ9
    Related
    ENSMUSP00000105901, OTTMUSP00000034484, ENSMUST00000110272, OTTMUST00000068286
    Conserved Domains (1) summary
    cd00012
    Location:50208
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_001286049.1NP_001272978.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001272978.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. It encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
    Source sequence(s)
    AC120402, AK002618, AK160950, CD775710
    Consensus CDS
    CCDS26045.1
    UniProtKB/Swiss-Prot
    Q9WUZ9
    Related
    ENSMUSP00000113106, OTTMUSP00000034486, ENSMUST00000122194, OTTMUST00000068289
    Conserved Domains (1) summary
    cd00012
    Location:50208
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001286058.1NP_001272987.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001272987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. It encodes the predominant protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
    Source sequence(s)
    AC120402, AK079267, AK160950, CD775710
    Consensus CDS
    CCDS26045.1
    UniProtKB/Swiss-Prot
    Q9WUZ9
    Related
    ENSMUSP00000114011, OTTMUSP00000034487, ENSMUST00000117286, OTTMUST00000068290
    Conserved Domains (1) summary
    cd00012
    Location:50208
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_007647.3NP_031673.2  ectonucleoside triphosphate diphosphohydrolase 5 isoform a

    See identical proteins and their annotated locations for NP_031673.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an internal exon in the 5' region, which results in an upstream AUG start codon, compared to variant 2. The resulting isoform (a) has a longer N-terminus, compared to isoform b.
    Source sequence(s)
    AK160950, AK163688, BY049870, CD775710
    Consensus CDS
    CCDS36491.1
    UniProtKB/Swiss-Prot
    Q9WUZ9
    UniProtKB/TrEMBL
    Q3TQC7
    Related
    ENSMUSP00000071939, ENSMUST00000072061
    Conserved Domains (1) summary
    cd00012
    Location:75233
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    84373875..84409029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515446.2XP_006515509.1  

    See identical proteins and their annotated locations for XP_006515509.1

    UniProtKB/TrEMBL
    Q3TQC7
    Conserved Domains (1) summary
    cd00012
    Location:75233
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_006515448.2XP_006515511.1  

    See identical proteins and their annotated locations for XP_006515511.1

    UniProtKB/Swiss-Prot
    Q9WUZ9
    Conserved Domains (1) summary
    cd00012
    Location:50208
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_006515447.2XP_006515510.1  

    See identical proteins and their annotated locations for XP_006515510.1

    UniProtKB/TrEMBL
    Q3TQC7
    Conserved Domains (1) summary
    cd00012
    Location:75233
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_006515449.2XP_006515512.1  

    See identical proteins and their annotated locations for XP_006515512.1

    UniProtKB/Swiss-Prot
    Q9WUZ9
    Conserved Domains (1) summary
    cd00012
    Location:50208
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  5. XM_006515451.2XP_006515514.1  

    See identical proteins and their annotated locations for XP_006515514.1

    UniProtKB/Swiss-Prot
    Q9WUZ9
    Conserved Domains (1) summary
    cd00012
    Location:50208
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    85828901..85864542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)