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    Ccne1 cyclin E1 [ Mus musculus (house mouse) ]

    Gene ID: 12447, updated on 11-May-2013
    Official Symbol
    Ccne1provided by MGI
    Official Full Name
    cyclin E1provided by MGI
    Primary source
    MGI:88316
    See related
    Ensembl:ENSMUSG00000002068; Vega:OTTMUSG00000022262
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycE1; AW538188
    Location :
    7 B2; 7 25.35 cM
    Sequence :
    Chromosome: 7; NC_000073.6 (38097984..38107490, complement)
    See Ccne1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 536 Neighboring gene RIKEN cDNA 4930505M18 gene Neighboring gene URI1, prefoldin-like chaperone Neighboring gene RIKEN cDNA 1600014C10 gene Neighboring gene pleckstrin homology domain containing, family F (with FYVE domain) member 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. Katoh K, et al. J Neurosci, 2012 Dec 5. PMID 23223288.
    2. Cell cycle regulation in mouse heart during embryonic and postnatal stages. Ikenishi A, et al. Dev Growth Differ, 2012 Oct. PMID 22957921.
    3. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. Bochkis IM, et al. PLoS Genet, 2012. PMID 22737085.
    4. Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Koss M, et al. Dev Cell, 2012 May 15. PMID 22560297.
    5. ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways. Srivastava R, et al. Mol Cell Biol, 2012 May. PMID 22411628.

    See all (154) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation.
      Title: Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation.
    2. Data show that gastric cancer markers MUC2, and oncogenes c-myc, cyclin E1 were expressed in the gastric carcinoma cell line 3I (MGCC3I).
      Title: Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules.
    3. our fi ndings reveal a direct link between cyclin E and HIF-1 activities in mammary epithelial cells and implicate HIF-1 as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers.
      Title: Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.
    4. Report presents the first detailed analysis of cyclin E expression in postmitotic neurons during development and in the adult mouse brain
      Title: Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain.
    5. Results show that deregulation of cyclin E expression contribute to infertility, due to inability of the spermatogonial cells to start the mitotic cycles prior to entering meiosis.
      Title: Reduced spermatogonial proliferation and decreased fertility in mice overexpressing cyclin E in spermatogonia.
    6. Depletion of cyclin E promoted apoptosis of breast cancer cells and blocked proliferation and transformation.
      Title: siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model.
    7. These results suggest that cyclin E up-regulation and p27(Kip1) loss-of-function act cooperatively on pituitary adenoma development.
      Title: Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.
    8. Data show that liver-specific ablation of the cyclin E regulator Cullin 3 in mice results in the persistence and massive expansion of hepatic progenitor cells.
      Title: The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells.
    9. cyclin E has a role in megakaryocytic polyploidization
      Title: New roles for cyclin E in megakaryocytic polyploidization.
    10. Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
      Title: The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
    Submit: New GeneRIF Correction See all (25)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NC_000073.1 NP_808401.1 E2f2    BIND  PubMed E2f2 (E2F-2) interacts with Ccne1 (cyclin E) promoter. 
    NC_000073.1 XP_127250.4 E2f3    BIND  PubMed E2f3 (E2F-3) interacts with Ccne1 (cyclin E) promoter. 
    NC_000073.1 NP_683754.1 E2f4    BIND  PubMed E2F-4 interacts with Cyclin E promoter. 
    NC_000073.1 NP_031918.2 E2f5    BIND  PubMed E2f5 (E2F-5) interacts with the Ccne1 (cyclin E) promoter. 
    NP_031659.1 NP_031685.2 Cdk1    BIND  PubMed Ccne1 (cyclin E1) interacts with Cdc2. 
    NP_031659.1 NP_034005.2 Cdkn1b    BIND  PubMed Cdkn1b (p27) interacts with Ccne1 (cyclin E1). 
    NP_031659.1 NP_034005.2 Cdkn1b    BIND  PubMed Ccne1 (Cyclin E) interacts, albeit weakly, with Cdkn1b (p27). This interaction was modeled on a demonstrated interaction between human Ccne1 (Cyclin E) and mouse Cdkn1b (p27). 
    BioGRID:198552 BioGRID:198644 Cdk2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:198552 BioGRID:198652 Cdkn1b    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198552 BioGRID:224997 H1    BioGRID  PubMed Biochemical Activity 
    BioGRID:198552 BioGRID:109264 HIST1H1B    BioGRID  PubMed Biochemical Activity 
    BioGRID:198552 BioGRID:170598 HIST1H1C    BioGRID  PubMed Biochemical Activity 
    BioGRID:198552 BioGRID:241423 Hdac1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198552 BioGRID:219818 Hist1h1a    BioGRID  PubMed Biochemical Activity 
    BioGRID:198552 BioGRID:202335 Ppp1ca    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198552 BioGRID:202515 Pura    BioGRID  PubMed Reconstituted Complex 
    BioGRID:198552 BioGRID:204403 Ubc    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Wnt receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Preferred Names
    G1/S-specific cyclin-E1
    Names
    G1/S-specific cyclin-E1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007633.2 → NP_031659.2  G1/S-specific cyclin-E1

      Status: PROVISIONAL

      Source sequence(s)
      BC106191
      Consensus CDS
      CCDS39914.1
      UniProtKB/Swiss-Prot
      Q61457
      Related
      ENSMUSP00000103658, OTTMUSP00000025179, ENSMUST00000108023, OTTMUST00000053001
      Conserved Domains (2) summary
      cd00043
      Location:142 – 232
      Blast Score: 187
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam02984
      Location:292 – 362
      Blast Score: 99
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p1 C57BL/6J

      Range
      38097984..38107490, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      33255165..33271131, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01060725.1 (23212..27594) None
    genomic AAHY01060726.1 None
    genomic AAHY01060727.1 None
    genomic AAHY01060728.1 None
    genomic AAHY01060729.1 None
    genomic AAHY01060730.1 None
    genomic AC166334.8 (94219..103564) None
    genomic CH466618.2 EDL02991.1 mixed
      EDL02992.1 mixed
    mRNA AK089950.1 None
    mRNA AK163046.1 None C57BL/6J
    mRNA AK165658.1 None
    mRNA AK177216.1 None
    mRNA AK178079.1 None
    mRNA BC003499.1 AAH03499.1
    mRNA BC062152.1 AAH62152.1
    mRNA BC084588.1 AAH84588.1
    mRNA BC106191.1 AAI06192.1
    mRNA BC138660.1 AAI38661.1
    mRNA BC138662.1 AAI38663.1
    mRNA X75888.1 CAA53482.1 129/J
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61457.2 GenPept UniProtKB/Swiss-Prot:Q61457

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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