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Cck cholecystokinin [ Mus musculus (house mouse) ]

Gene ID: 12424, updated on 10-May-2016
Official Symbol
Cckprovided by MGI
Official Full Name
cholecystokininprovided by MGI
Primary source
MGI:MGI:88297
See related
Ensembl:ENSMUSG00000032532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Homozygous knockout mice for this gene exhibit impaired insulin secretion, enhanced insulin sensitivity, and resistance to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Orthologs
Location:
9 72.43 cM; 9 F4
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (121489824..121495694, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (121398942..121404807, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene unc-51-like kinase 4 Neighboring gene predicted gene, 34655 Neighboring gene trafficking protein, kinesin binding 1 Neighboring gene predicted gene, 40585 Neighboring gene predicted gene, 38661 Neighboring gene lysozyme-like 4, opposite strand Neighboring gene lysozyme-like 4 Neighboring gene vasoactive intestinal peptide receptor 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hormone activity ISO
Inferred from Sequence Orthology
more info
 
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
eating behavior IDA
Inferred from Direct Assay
more info
PubMed 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon hillock ISO
Inferred from Sequence Orthology
more info
 
axon initial segment ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284508.2NP_001271437.1  cholecystokinin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271437.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded protein (isoform 2) is longer, has a distinct C-terminus, compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1.
    Source sequence(s)
    AC131660, AI842212, AK002677, BY268487
    UniProtKB/Swiss-Prot
    P09240
    UniProtKB/TrEMBL
    Q8R041
    Conserved Domains (1) summary
    pfam00918
    Location:271
    Gastrin; Gastrin/cholecystokinin family
  2. NM_031161.4NP_112438.1  cholecystokinin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_112438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AI842212, AK002677, BY268487
    Consensus CDS
    CCDS23631.1
    UniProtKB/Swiss-Prot
    P09240
    Related
    ENSMUSP00000035120, ENSMUST00000035120
    Conserved Domains (1) summary
    pfam00918
    Location:2115
    Gastrin; Gastrin/cholecystokinin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    121489824..121495694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    121960523..121966362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)