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Cbl Casitas B-lineage lymphoma [ Mus musculus (house mouse) ]

Gene ID: 12402, updated on 21-May-2016
Official Symbol
Cblprovided by MGI
Official Full Name
Casitas B-lineage lymphomaprovided by MGI
Primary source
MGI:MGI:88279
See related
Ensembl:ENSMUSG00000034342 Vega:OTTMUSG00000058274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cbl; Cbl-2; c-Cbl; 4732447J05Rik
Orthologs
Location:
9 A5.2; 9 24.72 cM
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (44145040..44234046, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (43957345..44042129, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10687 Neighboring gene melanoma cell adhesion molecule Neighboring gene coiled-coil domain containing 153 Neighboring gene PDZ domain containing 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
E3 ubiquitin-protein ligase CBL
Names
casitas B-lineage lymphoma proto-oncogene
proto-oncogene c-CBL
signal transduction protein CBL
NP_031645.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007619.2NP_031645.2  E3 ubiquitin-protein ligase CBL

    See identical proteins and their annotated locations for NP_031645.2

    Status: VALIDATED

    Source sequence(s)
    AC148328, AK029826, AK085140
    Consensus CDS
    CCDS40598.1
    UniProtKB/Swiss-Prot
    P22682
    Related
    ENSMUSP00000146244, OTTMUSP00000074620, ENSMUST00000206720, OTTMUST00000143117
    Conserved Domains (6) summary
    pfam02262
    Location:48174
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    PTZ00249
    Location:571724
    PTZ00249; variable surface protein Vir28; Provisional
    cd09920
    Location:254350
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:176260
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:379421
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14393
    Location:864903
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    44145040..44234046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509963.2XP_006510026.1  

    UniProtKB/TrEMBL
    A0A0X1KG61
    Related
    ENSMUSP00000041902, OTTMUSP00000074622, ENSMUST00000037644, OTTMUST00000143119
    Conserved Domains (6) summary
    pfam02262
    Location:48174
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    PTZ00249
    Location:527680
    PTZ00249; variable surface protein Vir28; Provisional
    cd09920
    Location:254350
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:176260
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:379421
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14393
    Location:820859
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    41406821..41486735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)