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Cav2 caveolin 2 [ Mus musculus (house mouse) ]

Gene ID: 12390, updated on 8-May-2016
Official Symbol
Cav2provided by MGI
Official Full Name
caveolin 2provided by MGI
Primary source
MGI:MGI:107571
See related
Ensembl:ENSMUSG00000000058 Vega:OTTMUSG00000024026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI447843
Summary
This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Orthologs
Location:
6; 6 A2
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (17281185..17289130)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (17231341..17239011)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102640738 Neighboring gene predicted gene 4876 Neighboring gene testis derived transcript Neighboring gene RIKEN cDNA D830026I12 gene Neighboring gene predicted gene 15581 Neighboring gene caveolin 1, caveolae protein Neighboring gene met proto-oncogene Neighboring gene predicted gene, 40355

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Splicing factor NOVA regulated synpatic proteins, organism-specific biosystem (from WikiPathways)
    Splicing factor NOVA regulated synpatic proteins, organism-specific biosystemSynaptic Communication influenced by NOVA-splicing regulation

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
D1 dopamine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding, bridging IDA
Inferred from Direct Assay
more info
PubMed 
protein complex scaffold IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
caveola assembly ISO
Inferred from Sequence Orthology
more info
 
caveola assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
endocytosis TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
positive regulation by host of viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated endocytosis of virus by host cell ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
vesicle docking ISO
Inferred from Sequence Orthology
more info
 
vesicle docking ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
vesicle fusion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
vesicle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
PubMed 
caveola ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
lipid particle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
transport vesicle ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277756.1NP_001264685.1  caveolin-2 isoform 2

    See identical proteins and their annotated locations for NP_001264685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter at the C-terminus, compared to isoform 1.
    Source sequence(s)
    AA475015, AC023173
    Consensus CDS
    CCDS71727.1
    UniProtKB/TrEMBL
    Q924U4
    Related
    ENSMUSP00000111119, OTTMUSP00000028504, ENSMUST00000115459, OTTMUST00000058749
    Conserved Domains (1) summary
    pfam01146
    Location:15113
    Caveolin; Caveolin
  2. NM_016900.4NP_058596.1  caveolin-2 isoform 1

    See identical proteins and their annotated locations for NP_058596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC023173, AK009913, AK151397, AK158419, CJ157462
    Consensus CDS
    CCDS19923.1
    UniProtKB/Swiss-Prot
    Q9WVC3
    Related
    ENSMUSP00000000058, OTTMUSP00000028503, ENSMUST00000000058, OTTMUST00000058748
    Conserved Domains (1) summary
    pfam01146
    Location:15162
    Caveolin; Caveolin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    17281185..17289130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    17353662..17361607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)