Cav1 caveolin 1, caveolae protein [Mus musculus] - Gene

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Summary

Official Symbol: Cav1provided by MGI
Official Full Name: caveolin 1, caveolae proteinprovided by MGI
Primary source: MGI:102709
See related: Ensembl:ENSMUSG00000007655; Vega:OTTMUSG00000024023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cav; Cav-1

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Genomic context

Location :: 6; 6 A2

Sequence :: Chromosome: 6; NC_000072.6 (17306335..17341328)

See Cav1 in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that interaction between Cav1 and Rho-GTPases (most likely RhoC but not RhoA) promotes metastasis by stimulating alpha5-integrin expression and regulating the Src-dependent activation of Ras/Erk1/2 signaling cascades.
Title: The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk.
Results identified caveolin-1 (Cav-1) as a RANKL-induced gene.
Title: Receptor activator of NF-κB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein.
in Cav-1(-/-) mouse, loss of Ano-1 expression, decrease of Substance P content and consequently overexpression of NK receptors suggest that all these molecules are Cav-1-associated proteins.
Title: NK receptors, Substance P, Ano1 expression and ultrastructural features of the muscle coat in Cav-1(-/-) mouse ileum.
The definitive role of Cav1 in promoting hepatocellular carcinoma tumourigenesis was demonstrated, and we have shown for the first time in a mouse model that Cav1 promotes metastasis.
Title: Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis.
Data show that cells expressing Cav1 have 2.6-fold more apoA-I binding sites than Cav1(-/-) cells although these additional binding sites are not associated with detergent-free lipid rafts.
Title: Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.
these data show that loss of caveolae results in a dramatic change to the membrane raft proteome and that this change is independent of Cav1 expression.
Title: Differential impact of caveolae and caveolin-1 scaffolds on the membrane raft proteome.
We observed that increased melanoma progression is associated with enhanced Cav-1 and FASN expression in tumors from HFD mice.
Title: Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN.
nonhematopoietic caveolin-1 determines plaque size, whereas hematopoietic caveolin-1 regulates lymphoid immune-modulation. However, both are required for phenotypic modulation of plaques.
Title: Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response.
Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B subunit occurs independently of caveolae
Title: Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae.
The hypoxia-induced down-regulation of Cav-1 contributes to enhanced neuronal differentiation in neural stem/progenitor cells.
Title: Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway.

Submit: New GeneRIF Correction See all (259)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (4) 1 citation
Targeted (Reporter) (1) 1 citation

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
AF124227.1	NP_034979.2	Myc		BIND	PubMed	Myc interacts with the Cav1 promoter.
NP_031642.1	NP_031809.2	Csk		BIND	PubMed	Csk interacts with Cav1 (caveolin).

Function	Evidence Code	Pubs
SNARE binding	ISO Inferred from Sequence Orthology more info
kinase binding	ISO Inferred from Sequence Orthology more info
nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
patched binding	ISO Inferred from Sequence Orthology more info
peptidase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor binding	ISO Inferred from Sequence Orthology more info
structural molecule activity	ISO Inferred from Sequence Orthology more info
syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
T cell costimulation	ISO Inferred from Sequence Orthology more info
calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
caveola assembly	ISO Inferred from Sequence Orthology more info
caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
cellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
cellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
cellular response to hyperoxia	ISO Inferred from Sequence Orthology more info
cholesterol efflux	ISO Inferred from Sequence Orthology more info
cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
cytosolic calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
endocytosis	TAS Traceable Author Statement more info	PubMed
inactivation of MAPK activity	IMP Inferred from Mutant Phenotype more info	PubMed
induction of apoptosis by extracellular signals	ISO Inferred from Sequence Orthology more info
lactation	IMP Inferred from Mutant Phenotype more info	PubMed
lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
maintenance of protein location in cell	ISO Inferred from Sequence Orthology more info
mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
mammary gland involution	IMP Inferred from Mutant Phenotype more info	PubMed
membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
microtubule polymerization	ISO Inferred from Sequence Orthology more info
negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of JAK-STAT cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of JAK-STAT cascade	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of JAK-STAT cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of canonical Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
negative regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tyrosine phosphorylation of Stat5 protein	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tyrosine phosphorylation of Stat5 protein	IMP Inferred from Mutant Phenotype more info	PubMed
nitric oxide homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of anti-apoptosis	ISO Inferred from Sequence Orthology more info
positive regulation of calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
positive regulation of canonical Wnt receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of metalloenzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
protein oligomerization	IDA Inferred from Direct Assay more info	PubMed
receptor internalization involved in canonical Wnt receptor signaling pathway	ISO Inferred from Sequence Orthology more info
regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
response to estrogen stimulus	ISO Inferred from Sequence Orthology more info	PubMed
response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
response to progesterone stimulus	ISO Inferred from Sequence Orthology more info	PubMed
skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
vesicle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
Golgi apparatus	ISO Inferred from Sequence Orthology more info
Golgi membrane	ISO Inferred from Sequence Orthology more info
acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	ISO Inferred from Sequence Orthology more info
basal plasma membrane	ISO Inferred from Sequence Orthology more info
basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
caveola	IDA Inferred from Direct Assay more info	PubMed
caveola	ISO Inferred from Sequence Orthology more info
caveola	TAS Traceable Author Statement more info	PubMed
cell	ISO Inferred from Sequence Orthology more info
cell cortex	IDA Inferred from Direct Assay more info	PubMed
cell surface	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
endosome	ISO Inferred from Sequence Orthology more info
flagellum	IDA Inferred from Direct Assay more info	PubMed
focal adhesion	ISO Inferred from Sequence Orthology more info
integral to membrane of membrane fraction	IDA Inferred from Direct Assay more info	PubMed
integral to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
intracellular	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular	ISO Inferred from Sequence Orthology more info
lipid particle	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
membrane fraction	ISO Inferred from Sequence Orthology more info
membrane raft	IDA Inferred from Direct Assay more info	PubMed
membrane raft	ISO Inferred from Sequence Orthology more info
mitochondrion	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
protein complex	IPI Inferred from Physical Interaction more info	PubMed
soluble fraction	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: caveolin-1

Names: caveolin-1; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243064.1 → NP_001229993.1 caveolin-1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AB029930, AK028738, AW488080, CK622116

UniProtKB/Swiss-Prot

P49817

Conserved Domains (1) summary

pfam01146
Location:3 – 146
Blast Score: 594

Caveolin; Caveolin
NM_007616.4 → NP_031642.1 caveolin-1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC023173, AK003489, AK028738, AW488080, BY235137

Consensus CDS

CCDS19924.1

UniProtKB/Swiss-Prot

P49817

Related

ENSMUSP00000007799, OTTMUSP00000028492, ENSMUST00000007799, OTTMUST00000058732

Conserved Domains (1) summary

pfam01146
Location:34 – 177
Blast Score: 617

Caveolin; Caveolin

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38 C57BL/6J

Range

17306335..17341328

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

17378800..17414674

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AB029931.1	BAA89463.1
genomic	AC023173.3 (106338..141326)	None	C57BL/6J
genomic	AE017189.1	AAR16290.1	C57BL/6J
genomic	CH466533.2	EDL13883.1	mixed
		EDL13884.1	mixed
		EDL13885.1	mixed
		EDL13886.1	mixed
		EDL13887.1	mixed
mRNA	AB029929.1	BAA89461.1
mRNA	AB029930.1	BAA89462.1
mRNA	AK003489.1	BAB22817.1	C57BL/6J
mRNA	AK010839.1	None	C57BL/6J
mRNA	AK028738.1	BAC26091.1	C57BL/6J
mRNA	AK035592.1	BAC29118.1	C57BL/6J
mRNA	AK090074.1	BAC41079.1
mRNA	AW488080.1	None	C57BL/6J
mRNA	AY439333.1	AAR99702.1	SWR/J
mRNA	BC038280.1	AAH38280.1	FVB/N
mRNA	BC052859.1	AAH52859.1	C3H/He
mRNA	BY235137.1	None	C57BL/6J
mRNA	CK622116.1	None	C57BL/6J
mRNA	U07645.1	AAA85784.1	BALB/c