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Ctnnd1 catenin (cadherin associated protein), delta 1 [ Mus musculus (house mouse) ]

Gene ID: 12388, updated on 8-May-2016
Official Symbol
Ctnnd1provided by MGI
Official Full Name
catenin (cadherin associated protein), delta 1provided by MGI
Primary source
MGI:MGI:105100
See related
Ensembl:ENSMUSG00000034101 Ensembl:ENSMUSG00000101645 Vega:OTTMUSG00000013442; Vega:OTTMUSG00000045966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P120; Catns; Ctnnd; AA409437; AU019353; mKIAA0384
Orthologs
Location:
2 D; 2 49.45 cM
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (84600781..84658972, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (84440938..84490897, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene tissue factor pathway inhibitor Neighboring gene predicted gene 13710 Neighboring gene RIKEN cDNA 2700094K13 gene Neighboring gene BTB (POZ) domain containing 18

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell differentiation involved in salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of a polarized epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine autophosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein processing IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
single organismal cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
midbody ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
zonula adherens ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
catenin delta-1
Names
CAS
cadherin-associated Src substrate
catenin src
p120 catenin
p120(cas)
p120(ctn)
p120-catenin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085448.1NP_001078917.1  catenin delta-1 isoform 2

    See identical proteins and their annotated locations for NP_001078917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a 5' UTR segment and an alternate exon in the 3' coding region (exon 18), compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK133193, AK161790, AL929079, BC043108, BY422861
    Consensus CDS
    CCDS50623.1
    UniProtKB/Swiss-Prot
    P30999
    Related
    ENSMUSP00000107326, ENSMUST00000111697
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  2. NM_001085449.1NP_001078918.1  catenin delta-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK161790, AK168453, AL929079, BC043108, BY422861
    Consensus CDS
    CCDS50621.1
    UniProtKB/Swiss-Prot
    P30999
    UniProtKB/TrEMBL
    E9Q986
    Related
    ENSMUSP00000107299, ENSMUST00000111670
    Conserved Domains (1) summary
    cd00020
    Location:262380
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  3. NM_001085450.1NP_001078919.1  catenin delta-1 isoform 1

    See identical proteins and their annotated locations for NP_001078919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC043108, BY422861, CJ174738
    Consensus CDS
    CCDS16186.1
    UniProtKB/Swiss-Prot
    P30999
    Related
    ENSMUSP00000107320, OTTMUSP00000014428, ENSMUST00000111691, OTTMUST00000032490
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  4. NM_001085453.1NP_001078922.1  catenin delta-1 isoform 4

    See identical proteins and their annotated locations for NP_001078922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. Variant 5 is also known as CAS 1B.
    Source sequence(s)
    AK161790, AK168453, BC043108, BC054544, BY061937, BY422861
    Consensus CDS
    CCDS50622.1
    UniProtKB/Swiss-Prot
    P30999
    Related
    ENSMUSP00000065252, OTTMUSP00000014431, ENSMUST00000066177, OTTMUST00000032493
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  5. NM_007615.4NP_031641.2  catenin delta-1 isoform 1

    See identical proteins and their annotated locations for NP_031641.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC043108, BC054544, BY422861, CJ174738
    Consensus CDS
    CCDS16186.1
    UniProtKB/Swiss-Prot
    P30999
    Related
    ENSMUSP00000064518, OTTMUSP00000014429, ENSMUST00000067232, OTTMUST00000032491
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    84600781..84658972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498635.1XP_006498698.1  

    See identical proteins and their annotated locations for XP_006498698.1

    UniProtKB/Swiss-Prot
    P30999
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  2. XM_006498630.1XP_006498693.1  

    See identical proteins and their annotated locations for XP_006498693.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  3. XM_006498634.2XP_006498697.1  

    UniProtKB/TrEMBL
    E9Q8Z5
    Related
    ENSMUSP00000107325, OTTMUSP00000014456, ENSMUST00000111696, OTTMUST00000032556
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  4. XM_006498632.2XP_006498695.1  

    UniProtKB/TrEMBL
    E9Q8Z6
    Related
    ENSMUSP00000107316, OTTMUSP00000014459, ENSMUST00000111687, OTTMUST00000032559
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  5. XM_006498638.1XP_006498701.1  

    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  6. XM_006498633.2XP_006498696.1  

    Related
    ENSMUSP00000107314, OTTMUSP00000014462, ENSMUST00000111685, OTTMUST00000032562
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  7. XM_006498636.2XP_006498699.1  

    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  8. XM_006498631.2XP_006498694.1  

    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  9. XM_006498625.2XP_006498688.1  

    See identical proteins and their annotated locations for XP_006498688.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Related
    ENSMUSP00000107313, OTTMUSP00000014457, ENSMUST00000111684, OTTMUST00000032557
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  10. XM_006498639.2XP_006498702.1  

    UniProtKB/TrEMBL
    E9Q905
    Related
    ENSMUSP00000107307, OTTMUSP00000014460, ENSMUST00000111678, OTTMUST00000032560
    Conserved Domains (1) summary
    cd00020
    Location:262380
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  11. XM_006498626.2XP_006498689.1  

    See identical proteins and their annotated locations for XP_006498689.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Related
    ENSMUSP00000107323, OTTMUSP00000014472, ENSMUST00000111694, OTTMUST00000032572
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  12. XM_006498628.2XP_006498691.1  

    See identical proteins and their annotated locations for XP_006498691.1

    UniProtKB/TrEMBL
    E9Q8Z8
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  13. XM_011239267.1XP_011237569.1  

    See identical proteins and their annotated locations for XP_011237569.1

    UniProtKB/Swiss-Prot
    P30999
    Related
    ENSMUSP00000042543, OTTMUSP00000014430, ENSMUST00000036811, OTTMUST00000032492
    Conserved Domains (1) summary
    cd00020
    Location:363481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    86195656..86245817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)