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Casr calcium-sensing receptor [ Mus musculus (house mouse) ]

Gene ID: 12374, updated on 28-May-2016
Official Symbol
Casrprovided by MGI
Official Full Name
calcium-sensing receptorprovided by MGI
Primary source
MGI:MGI:1351351
See related
Ensembl:ENSMUSG00000051980 Vega:OTTMUSG00000037977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaR; Gprc2a
Orthologs
Location:
16 B3; 16 25.57 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (36490585..36562141, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (36493782..36562220, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene stefin A2 Neighboring gene stefin A3 Neighboring gene CD86 antigen Neighboring gene predicted gene, 41451

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
polyamine binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
JNK cascade ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
calcium ion import ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
ossification ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
extracellular calcium-sensing receptor
Names
G protein coupled receptor, family C, group 2, member A
G protein-coupled receptor, family C, group 2, member A
PCaR1
cation sensing receptor
parathyroid cell calcium-sensing receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013803.2NP_038831.2  extracellular calcium-sensing receptor precursor

    See identical proteins and their annotated locations for NP_038831.2

    Status: VALIDATED

    Source sequence(s)
    AC074229, AF110178, AF110179, AK029770
    Consensus CDS
    CCDS28154.1
    UniProtKB/Swiss-Prot
    Q9QY96
    UniProtKB/TrEMBL
    Q8CDP3
    Related
    ENSMUSP00000069080, OTTMUSP00000054890, ENSMUST00000063597, OTTMUST00000097874
    Conserved Domains (5) summary
    cd06364
    Location:20530
    PBP1_CaSR; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:622860
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:69495
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:682854
    ABC2_membrane_3; ABC-2 family transporter protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    36490585..36562141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521730.2XP_006521793.1  

    See identical proteins and their annotated locations for XP_006521793.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (5) summary
    cd06364
    Location:20530
    PBP1_CaSR; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:622860
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:69495
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:682854
    ABC2_membrane_3; ABC-2 family transporter protein
  2. XM_006521731.2XP_006521794.1  

    See identical proteins and their annotated locations for XP_006521794.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Related
    ENSMUSP00000133500, OTTMUSP00000054891, ENSMUST00000172826, OTTMUST00000097875
    Conserved Domains (5) summary
    cd06364
    Location:20530
    PBP1_CaSR; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:622860
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:69495
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:682854
    ABC2_membrane_3; ABC-2 family transporter protein
  3. XM_006521732.2XP_006521795.1  

    See identical proteins and their annotated locations for XP_006521795.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (5) summary
    cd06364
    Location:20530
    PBP1_CaSR; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:622860
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:69495
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:682854
    ABC2_membrane_3; ABC-2 family transporter protein
  4. XM_006521729.2XP_006521792.1  

    See identical proteins and their annotated locations for XP_006521792.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (5) summary
    cd06364
    Location:20530
    PBP1_CaSR; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:622860
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:69495
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:682854
    ABC2_membrane_3; ABC-2 family transporter protein
  5. XM_006521734.2XP_006521797.1  

    See identical proteins and their annotated locations for XP_006521797.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (5) summary
    cd06364
    Location:20530
    PBP1_CaSR; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:622860
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:69495
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:682854
    ABC2_membrane_3; ABC-2 family transporter protein
  6. XM_006521733.2XP_006521796.1  

    See identical proteins and their annotated locations for XP_006521796.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (5) summary
    cd06364
    Location:20530
    PBP1_CaSR; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam00003
    Location:622860
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:69495
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:682854
    ABC2_membrane_3; ABC-2 family transporter protein
  7. XM_006521735.2XP_006521798.1  

    Conserved Domains (5) summary
    pfam00003
    Location:472710
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:15345
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:388441
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam12698
    Location:532704
    ABC2_membrane_3; ABC-2 family transporter protein
    cl10011
    Location:14380
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    36909014..36977753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)