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Casq1 calsequestrin 1 [ Mus musculus (house mouse) ]

Gene ID: 12372, updated on 8-May-2016
Official Symbol
Casq1provided by MGI
Official Full Name
calsequestrin 1provided by MGI
Primary source
MGI:MGI:1309468
See related
Ensembl:ENSMUSG00000007122 Vega:OTTMUSG00000035165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSQ; CSQ1; sCSQ; CSQ-1
Orthologs
Location:
1 H3; 1 79.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (172209894..172219895, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (174140025..174150026, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 8 Neighboring gene phosphoprotein enriched in astrocytes 15A Neighboring gene predicted gene 17224 Neighboring gene ATPase, Na+/K+ transporting, alpha 4 polypeptide Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene predicted gene, 38511 Neighboring gene ATPase, Na+/K+ transporting, alpha 2 polypeptide Neighboring gene predicted gene, 39704

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
I band ISO
Inferred from Sequence Orthology
more info
 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myofibril ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
sarcoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
terminal cisterna ISO
Inferred from Sequence Orthology
more info
 
terminal cisterna lumen ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
calsequestrin-1
Names
calmitine
calsequestrin, skeletal muscle isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009813.2NP_033943.2  calsequestrin-1 precursor

    See identical proteins and their annotated locations for NP_033943.2

    Status: VALIDATED

    Source sequence(s)
    AK049865, AW108209, BC064057, BY772893, CR756967
    Consensus CDS
    CCDS35781.2
    UniProtKB/Swiss-Prot
    O09165
    UniProtKB/TrEMBL
    Q6P3C3, Q8C7M8
    Related
    ENSMUSP00000003554, OTTMUSP00000048962, ENSMUST00000003554, OTTMUST00000089560
    Conserved Domains (4) summary
    cd03065
    Location:39158
    PDI_b_Calsequestrin_N; PDIb family, Calsequestrin subfamily, N-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...
    cd03066
    Location:160261
    PDI_b_Calsequestrin_middle; PDIb family, Calsequestrin subfamily, Middle TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...
    cd03074
    Location:262381
    PDI_b'_Calsequestrin_C; Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient ...
    pfam01216
    Location:35388
    Calsequestrin; Calsequestrin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    172209894..172219895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    175065863..175075868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)