Casp8 caspase 8 [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Casp8provided by MGI
Official Full Name: caspase 8provided by MGI
Primary source: MGI:1261423
See related: Ensembl:ENSMUSG00000026029
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MACH; Mch5; FLICE; CASP-8
Summary: This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Genomic context

Go to the top of the page Help

Location :: 1 B; 1 29.19 cM

Sequence :: Chromosome: 1; NC_000067.6 (58795374..58847503)

See Casp8 in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The FADD-CASPASE-8-cFLIP(L) complex functions in the survival of developing mouse embryos.
Title: Survival function of the FADD-CASPASE-8-cFLIP(L) complex.
DP T cell apoptosis following experimental T. cruzi acute infection is dependent on glucocorticoid stimulation, promoting caspase-8 and -9 activation
Title: Caspase-8 and caspase-9 mediate thymocyte apoptosis in Trypanosoma cruzi acutely infected mice.
These results uncover a new mechanism of caspase-8-mediated apoptosis induced by intracellular calcium overload that is dependent on the autophagy-related proteins LC3 and p62 upon hyperactivation of DEG/ENaC channels.
Title: Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis.
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome
Title: Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.
Fas (CD95) signaling activates caspase-8 in macrophages and dendritic cells, leading to the maturation of interleukin (IL)-1beta and IL-18 independently of inflammasomes or receptor-interacting protein (RIP)3.
Title: Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.
procaspase-8 activity is essential for cell survival by inhibiting both apoptotic and nonapoptotic cell death dependent on receptor-interacting protein kinase 1 (RIP1) and RIP3
Title: Protease activity of procaspase-8 is essential for cell survival by inhibiting both apoptotic and nonapoptotic cell death dependent on receptor-interacting protein kinase 1 (RIP1) and RIP3.
analysis of Fas mediated caspase-8 independent apoptosis in human and mouse immune cells by Armigeres subalbatus saliva
Title: Induction of Fas mediated caspase-8 independent apoptosis in immune cells by Armigeres subalbatus saliva.
The results show that in MEFs, caspase-8 is necessary for TNF- and FasL-induced death, and FLIP is needed to prevent it, but neither caspase-8 nor FLIP is required for TNF to activate NF-kappaB.
Title: In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.
Important role for caspase-8 in the maintenance of genomic integrity and its tumor-suppressive function.
Title: Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.
The autophagosomal membrane serves as a platform for an intracellular death-inducing signaling complex (iDISC) that recruits self-associated caspase-8 to initiate the caspase-8/-3 cascade.
Title: Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis.

Submit: New GeneRIF Correction See all (88)

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (4) 1 citation
Targeted (knock-out) (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_033942.1	NP_034013.1	Cebpb	BIND	PubMed	C/EBP-beta interacts with procaspase 8.
NP_033942.1	NP_084428.1	Nol3	BIND	PubMed	ARC interacts with procaspase-8.
BioGRID:198500	BioGRID:198146	Atg5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198500	BioGRID:216612	Cyld	BioGRID	PubMed	Biochemical Activity
BioGRID:198500	BioGRID:199586	Fadd	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198500	BioGRID:201982	Sqstm1	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:198500	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198500	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

Go to the top of the page Help

Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem (from REACTOME)
Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
Apoptosis Modulation by HSP70, organism-specific biosystem
Apoptosis Modulation by HSP70
Apoptosis signaling pathway, organism-specific biosystem (from LIPID MAPS)
Apoptosis signaling pathway, organism-specific biosystem
Apoptosis signaling pathway
Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
Apoptotic cleavage of cellular proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic execution phase, organism-specific biosystem (from REACTOME)
Apoptotic execution phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Caspase-8 activation, organism-specific biosystem (from REACTOME)
Caspase-8 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Death Receptor Signalling, organism-specific biosystem (from REACTOME)
Death Receptor Signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dimerization of procaspase-8, organism-specific biosystem (from REACTOME)
Dimerization of procaspase-8, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Extrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Extrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
FasL/ CD95L signaling, organism-specific biosystem (from REACTOME)
FasL/ CD95L signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Legionellosis, organism-specific biosystem (from KEGG)
Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Legionellosis, conserved biosystem (from KEGG)
Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MyD88-independent cascade, organism-specific biosystem (from REACTOME)
MyD88-independent cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem (from REACTOME)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
NOD1/2 Signaling Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
TLR4 (Toll-like receptor 4) signaling pathway
TNF signaling, organism-specific biosystem (from REACTOME)
TNF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
TNF-alpha NF-kB Signaling Pathway
TRAIL signaling, organism-specific biosystem (from REACTOME)
TRAIL signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated programmed cell death, organism-specific biosystem (from REACTOME)
TRIF-mediated programmed cell death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
Toll Like Receptor signaling, organism-specific biosystem
Toll Like Receptor signaling
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
p53 signaling pathway, organism-specific biosystem (from KEGG)
p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53 signaling pathway, conserved biosystem (from KEGG)
p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

Go to the top of the page Help

Markers

D1Mit414 (e-PCR), detects polymorphism
- UniSTS:128778

Casp8 (e-PCR), detects polymorphism
- UniSTS:498225

AF067834 (e-PCR)
- UniSTS:158798

Casp8 (e-PCR), detects polymorphism
- UniSTS:141238

Homology

Homologs of the Casp8 gene: The Casp8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
identical protein binding	ISO Inferred from Sequence Orthology more info
peptidase activity	IDA Inferred from Direct Assay more info	PubMed
peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protease binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	ISO Inferred from Sequence Orthology more info
apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
heart development	IMP Inferred from Mutant Phenotype more info	PubMed
macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
metabolic process	IDA Inferred from Direct Assay more info	PubMed
metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
protein heterooligomerization	ISO Inferred from Sequence Orthology more info
proteolysis	ISO Inferred from Sequence Orthology more info
proteolysis involved in cellular protein catabolic process	ISO Inferred from Sequence Orthology more info
regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
response to ethanol	ISO Inferred from Sequence Orthology more info
response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
CD95 death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
Noc1p-Noc2p complex	IMP Inferred from Mutant Phenotype more info	PubMed
cell body	ISO Inferred from Sequence Orthology more info
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
membrane raft	ISO Inferred from Sequence Orthology more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info
neuron projection	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: caspase-8

Names: caspase-8; Fas-linked ICE-like protease

NP_001073595.1

EC 3.4.22.61

NP_033942.1

EC 3.4.22.61

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080126.1 → NP_001073595.1 caspase-8 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 both encode isoform (1).

Source sequence(s)

AC112968, AK146758, AK153340

Consensus CDS

CCDS14979.1

UniProtKB/Swiss-Prot

O89110

UniProtKB/TrEMBL

Q3U607

Related

ENSMUSP00000127375, ENSMUST00000165549

Conserved Domains (2) summary

cd00032
Location:227 – 479
Blast Score: 743

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:3 – 84
Blast Score: 269

DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains
NM_001277926.1 → NP_001264855.1 caspase-8 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.

Source sequence(s)

AC112968, AK146758, AK153340, BY203369

Conserved Domains (2) summary

cd00032
Location:247 – 499
Blast Score: 811

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:23 – 104
Blast Score: 266

DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains
NM_009812.2 → NP_033942.1 caspase-8 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode isoform (1).

Source sequence(s)

AK146758

Consensus CDS

CCDS14979.1

UniProtKB/Swiss-Prot

O89110

UniProtKB/TrEMBL

Q3U607

Related

ENSMUSP00000027189, ENSMUST00000027189

Conserved Domains (2) summary

cd00032
Location:227 – 479
Blast Score: 743

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:3 – 84
Blast Score: 269

DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38.p1 C57BL/6J

Range

58795374..58847503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

59314392..59366511

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01006622.1	None
genomic	AAHY01006623.1	None
genomic	AAHY01006624.1	None
genomic	AC112968.11 (168664..181519)	None
genomic	AC120554.12 (11916..50579)	None
genomic	AF067835.1	AAC40132.1	129/SvJ
genomic	AF067836.1	AAC40132.1	129/SvJ
genomic	AF067837.1	AAC40132.1	129/SvJ
genomic	AF067838.1	AAC40132.1	129/SvJ
genomic	AF067839.1	AAC40132.1	129/SvJ
genomic	AF067840.1	AAC40132.1	129/SvJ
genomic	AF067841.1	AAC40132.1	129/SvJ
genomic	CH466548.1	EDL00099.1	mixed
		EDL00100.1	mixed
mRNA	AF067834.1	AAC40131.1
mRNA	AJ000641.1	CAA04196.1
mRNA	AJ007749.1	CAA07677.1
mRNA	AK146758.1	BAE27412.1	C57BL/6J
mRNA	AK153340.1	BAE31918.1	C57BL/6J
mRNA	AK156135.1	None	NOD
mRNA	AK168812.1	BAE40639.1	C57BL/6J
mRNA	AK185575.1	None
mRNA	BC006737.1	AAH06737.1	FVB/N
mRNA	BC049955.1	AAH49955.1	FVB/N
mRNA	BY203369.1	None	C57BL/6J
mRNA	CT010166.1	CAJ18374.1