Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Casp8 caspase 8 [ Mus musculus (house mouse) ]

Gene ID: 12370, updated on 8-Jul-2014
Official Symbol
Casp8provided by MGI
Official Full Name
caspase 8provided by MGI
Primary source
MGI:1261423
See related
Ensembl:ENSMUSG00000026029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MACH; Mch5; FLICE; CASP-8
Summary
This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]
See Casp8 in Epigenomics, MapViewer
Location:
1 B; 1 29.19 cM
Exon count :
11
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (58795229..58847503)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 (human) Neighboring gene uncharacterized LOC102636336 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog Neighboring gene trafficking protein, kinesin binding 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity IGI
Inferred from Genetic Interaction
more info
 
cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
death effector domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
death effector domain binding ISO
Inferred from Sequence Orthology
more info
 
death receptor binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity IDA
Inferred from Direct Assay
more info
 
endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
 
neural tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
proteolysis IGI
Inferred from Genetic Interaction
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of thymocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
Noc1p-Noc2p complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
ripoptosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
caspase-8
Names
caspase-8
Fas-linked ICE-like protease
NP_001073595.1
NP_001264855.1
NP_033942.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080126.1NP_001073595.1  caspase-8 isoform 1 precursor

    See proteins identical to NP_001073595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 both encode isoform (1).
    Source sequence(s)
    AC112968, AK146758, AK153340
    Consensus CDS
    CCDS14979.1
    UniProtKB/Swiss-Prot
    O89110
    UniProtKB/TrEMBL
    Q3U607
    Related
    ENSMUSP00000127375, ENSMUST00000165549
    Conserved Domains (3) summary
    cd00032
    Location:227479
    Blast Score: 813
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    Blast Score: 370
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    Blast Score: 290
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_001277926.1NP_001264855.1  caspase-8 isoform 2

    See proteins identical to NP_001264855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC112968, AK146758, AK153340, BY203369
    UniProtKB/TrEMBL
    Q3U607
    Conserved Domains (3) summary
    cd00032
    Location:247499
    Blast Score: 813
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:23104
    Blast Score: 366
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:118199
    Blast Score: 289
    DD; Death Domain Superfamily of protein-protein interaction domains
  3. NM_009812.2NP_033942.1  caspase-8 isoform 1 precursor

    See proteins identical to NP_033942.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode isoform (1).
    Source sequence(s)
    AK146758
    Consensus CDS
    CCDS14979.1
    UniProtKB/Swiss-Prot
    O89110
    UniProtKB/TrEMBL
    Q3U607
    Related
    ENSMUSP00000027189, ENSMUST00000027189
    Conserved Domains (3) summary
    cd00032
    Location:227479
    Blast Score: 813
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    Blast Score: 370
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    Blast Score: 290
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    58795229..58847503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495634.1XP_006495697.1  

    See proteins identical to XP_006495697.1

    Conserved Domains (3) summary
    cd00032
    Location:247499
    Blast Score: 813
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:23104
    Blast Score: 366
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:118199
    Blast Score: 289
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    59314392..59366511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...