Casp3 caspase 3 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Casp3provided by MGI
Official Full Name: caspase 3provided by MGI
Primary source: MGI:107739
See related: Ensembl:ENSMUSG00000031628
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CC3; AC-3; Lice; Yama; mldy; CPP32; Apopain; Caspase-3; A830040C14Rik

Genomic context

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Location :: 8 B1.1; 8 26.39 cM

Sequence :: Chromosome: 8; NC_000074.6 (46617449..46638717)

See Casp3 in Epigenomics, MapViewer

Chromosome 8 - NC_000074.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that control of CYP24A1 increase during diabetes has a beneficial effect on senescence induction and caspase-3 increased expression.
Title: CYP24A1 exacerbated activity during diabetes contributes to kidney tubular apoptosis via caspase-3 increased expression and activation.
Caspase 1 and 3 are involved in Chlamydia-induced infertility.
Title: Prevention of Chlamydia-induced infertility by inhibition of local caspase activity.
both Caspase-3 and Caspase-6 are implicated in axon degeneration that occurs as a part of normal development.
Title: A caspase cascade regulating developmental axon degeneration.
putple rice extract (PRE), cyanidin, and HHPG suppress tunicamycin-induced retinal ganglion cell death at least partly by inhibiting activation of caspase-3; PRE and its main constituents prevent retinal disease caused by ER stress
Title: Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo.
exposure to the EMF of 1950-MHz TD-SCDMA may not promote the tumor formation, but continuous exposure damaged the mitochondria of astrocytes and induce apoptosis through a caspase-3-dependent pathway with the involvement of bax and bcl-2.
Title: Exposure to 1950-MHz TD-SCDMA electromagnetic fields affects the apoptosis of astrocytes via caspase-3-dependent pathway.
Grape procyanidins could suppress the expression of Caspase-3 and Bax in the liver of mice with ethanol-induced liver injury.
Title: [Effect of grape procyanidins on expressions of Caspase-3 and Bax in ethanol-induced liver injury in mice].
Caspase-3 siRNA may reduce neurotoxicity induced by aluminum
Title: [The effects of caspase-3 siRNA on the neurobehavior of mice exposed to aluminum].
TNF-alpha-induced apoptosis and Caspase-3 expression in mouse skin keratinocytes in vivo and in vitro
Title: Gsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes.
Caspase-3 is a stress intensity sensor that controls cell fate by either initiating a RasGAP cleavage-dependent cell resistance program or a cell suicide response mediated by akt.
Title: Caspase-3 protects stressed organs against cell death.
Levels of caspase-3 activity, differ among alphabeta and gammadelta effector T-cell subsets and the degree of redistribution of active caspase from the cell membrane to the cytoplasm upon TCR restimulation is proportional to the susceptibility to cell death.
Title: Proliferating γδ T cells manifest high and spatially confined caspase-3 activity.

Submit: New GeneRIF Correction See all (150)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation
Targeted (Reporter) (1) 1 citation
Chemically induced (ENU) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:198497	BioGRID:198147	Birc3	BioGRID	PubMed	Biochemical Activity
BioGRID:198497	BioGRID:199211	Dffa	BioGRID	PubMed	Biochemical Activity
BioGRID:198497	BioGRID:115421	FEM1B	BioGRID	PubMed	Biochemical Activity
BioGRID:198497	BioGRID:202435	Psme3	BioGRID	PubMed	Biochemical Activity
BioGRID:198497	BioGRID:203290	Slc1a2	BioGRID	PubMed	Biochemical Activity
BioGRID:198497	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198497	BioGRID:204619	Ywhae	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Activation of DNA fragmentation factor, organism-specific biosystem (from REACTOME)
Activation of DNA fragmentation factor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem (from REACTOME)
Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
Apoptosis Modulation by HSP70, organism-specific biosystem
Apoptosis Modulation by HSP70
Apoptosis induced DNA fragmentation, organism-specific biosystem (from REACTOME)
Apoptosis induced DNA fragmentation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis signaling pathway, organism-specific biosystem (from LIPID MAPS)
Apoptosis signaling pathway, organism-specific biosystem
Apoptosis signaling pathway
Apoptotic cleavage of cell adhesion proteins, organism-specific biosystem (from REACTOME)
Apoptotic cleavage of cell adhesion proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
Apoptotic cleavage of cellular proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic execution phase, organism-specific biosystem (from REACTOME)
Apoptotic execution phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic factor-mediated response, organism-specific biosystem (from REACTOME)
Apoptotic factor-mediated response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Cytochrome c-mediated apoptotic response, organism-specific biosystem (from REACTOME)
Cytochrome c-mediated apoptotic response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Legionellosis, organism-specific biosystem (from KEGG)
Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Legionellosis, conserved biosystem (from KEGG)
Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
NADE modulates death signalling, organism-specific biosystem (from REACTOME)
NADE modulates death signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Oxidative Damage, organism-specific biosystem (from WikiPathways)
Oxidative Damage, organism-specific biosystem
Oxidative Damage
Parkinson's disease, organism-specific biosystem (from KEGG)
Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Apoptosis, organism-specific biosystem (from REACTOME)
Regulation of Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Role of DCC in regulating apoptosis, organism-specific biosystem (from REACTOME)
Role of DCC in regulating apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SMAC binds to IAPs, organism-specific biosystem (from REACTOME)
SMAC binds to IAPs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SMAC-mediated apoptotic response, organism-specific biosystem (from REACTOME)
SMAC-mediated apoptotic response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystem (from REACTOME)
SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Serotonergic synapse, organism-specific biosystem (from KEGG)
Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Hippo, organism-specific biosystem (from REACTOME)
Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Stimulation of the cell death response by PAK-2p34, organism-specific biosystem (from REACTOME)
Stimulation of the cell death response by PAK-2p34, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
TNF-alpha NF-kB Signaling Pathway
Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
Toll Like Receptor signaling, organism-specific biosystem
Toll Like Receptor signaling
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
p53 signaling pathway, organism-specific biosystem (from KEGG)
p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53 signaling pathway, conserved biosystem (from KEGG)
p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
p75 NTR receptor-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

PMC316633P1 (e-PCR)
- UniSTS:273022

Casp3 (e-PCR), detects polymorphism
- UniSTS:259200

Casp3 (e-PCR), detects polymorphism
- UniSTS:525205

PMC148819P9 (e-PCR)
- UniSTS:271022

Casp3 (e-PCR), detects polymorphism
- UniSTS:141232

Casp3 (e-PCR), detects polymorphism
- UniSTS:141233

Casp3 (e-PCR), detects polymorphism
- UniSTS:141234

Casp3 (e-PCR), detects polymorphism
- UniSTS:141235

Casp3 (e-PCR), detects polymorphism
- UniSTS:141236

Casp3 (e-PCR), detects polymorphism
- UniSTS:141237

Homology

Homologs of the Casp3 gene: The Casp3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and mosquito.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
cyclin-dependent protein serine/threonine kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
peptidase activity	IDA Inferred from Direct Assay more info	PubMed
peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
peptidase activity	ISO Inferred from Sequence Orthology more info
peptidase activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
phospholipase A2 activator activity	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic DNA fragmentation	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	ISO Inferred from Sequence Orthology more info
cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
heart development	IGI Inferred from Genetic Interaction more info	PubMed
induction of apoptosis	IDA Inferred from Direct Assay more info	PubMed
induction of apoptosis	IGI Inferred from Genetic Interaction more info	PubMed
induction of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
induction of apoptosis	RCA inferred from Reviewed Computational Analysis more info	PubMed
intracellular signal transduction	ISO Inferred from Sequence Orthology more info
intrinsic apoptotic signaling pathway in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
learning or memory	ISO Inferred from Sequence Orthology more info
negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
nuclear fragmentation involved in apoptotic nuclear change	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
protein processing	IDA Inferred from Direct Assay more info	PubMed
proteolysis	ISO Inferred from Sequence Orthology more info
proteolysis	RCA inferred from Reviewed Computational Analysis more info	PubMed
release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed
response to UV	IDA Inferred from Direct Assay more info	PubMed
response to UV	IGI Inferred from Genetic Interaction more info	PubMed
response to glucose stimulus	ISO Inferred from Sequence Orthology more info
response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
response to wounding	IDA Inferred from Direct Assay more info	PubMed
sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
mitochondrion	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-3

Names: caspase-3; SCA-1; CASP-3; CPP-32; protein Yama; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis related cysteine protease

NP_033940.1

EC 3.4.22.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009810.2 → NP_033940.1 caspase-3

Status: PROVISIONAL

Source sequence(s)

AC119267

Consensus CDS

CCDS22294.1

UniProtKB/Swiss-Prot

P70677

Related

ENSMUSP00000091238, ENSMUST00000093517

Conserved Domains (1) summary

cd00032
Location:37 – 275
Blast Score: 791

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000074.6 Reference GRCm38.p1 C57BL/6J

Range

46617449..46638717

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000030.1 Alternate Mm_Celera

Range

49300031..49321270

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01070430.1	None
genomic	AAHY01070431.1 (393..18334)	None
genomic	AC119267.8 (83412..104681)	None
genomic	CH466554.1	EDL35577.1	mixed
		EDL35578.1	mixed
		EDL35579.1	mixed
		EDL35580.1	mixed
		EDL35581.1	mixed
		EDL35582.1	mixed
genomic	U54801.1	None
genomic	U54802.1	AAC52768.1
genomic	U54803.1	AAC52768.1
mRNA	AK014231.1	None	C57BL/6J
mRNA	AK049043.1	None	C57BL/6J
mRNA	AK080651.1	BAC37969.1	C57BL/6J
mRNA	AK146226.1	None	BALB/c
mRNA	BC021500.1	None	FVB/N
mRNA	BC038825.1	AAH38825.2	FVB/N
mRNA	D86352.1	BAA21727.1
mRNA	U19522.1	AAC53196.1
mRNA	U49929.1	AAC52764.1
mRNA	U63720.1	AAD09504.1
mRNA	Y13086.1	CAA73528.1	C3H/An