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Casp3 caspase 3 [ Mus musculus (house mouse) ]

Gene ID: 12367, updated on 16-Apr-2014
Official Symbol
Casp3provided by MGI
Official Full Name
caspase 3provided by MGI
Primary source
MGI:107739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC3; AC-3; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Apopain; Caspase-3; A830040C14Rik
Location :
8 B1.1; 8 26.39 cM
Sequence :
Chromosome: 8; NC_000074.6 (46617291..46639698)
See Casp3 in Epigenomics, MapViewer

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase long-chain family member 1 Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene uncharacterized LOC102633233 Neighboring gene predicted gene, 16675

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
phospholipase A2 activator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
execution phase of apoptosis IGI
Inferred from Genetic Interaction
more info
PubMed 
execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
protein processing IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
response to UV IDA
Inferred from Direct Assay
more info
PubMed 
response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
response to glucose ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
caspase-3
Names
caspase-3
protein Yama
cysteine protease CPP32
SREBP cleavage activity 1
caspase 3, apoptosis related cysteine protease
NP_001271338.1
NP_033940.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284409.1NP_001271338.1  caspase-3

    See proteins identical to NP_001271338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC119267
    Consensus CDS
    CCDS22294.1
    UniProtKB/Swiss-Prot
    P70677
    Conserved Domains (1) summary
    cd00032
    Location:37275
    Blast Score: 883
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  2. NM_009810.3NP_033940.1  caspase-3

    See proteins identical to NP_033940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC119267
    Consensus CDS
    CCDS22294.1
    UniProtKB/Swiss-Prot
    P70677
    Conserved Domains (1) summary
    cd00032
    Location:37275
    Blast Score: 883
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p2 C57BL/6J

    Range
    46617291..46639698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    49299873..49322279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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