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Capn3 calpain 3 [ Mus musculus (house mouse) ]

Gene ID: 12335, updated on 8-May-2016
Official Symbol
Capn3provided by MGI
Official Full Name
calpain 3provided by MGI
Primary source
MGI:MGI:107437
See related
Ensembl:ENSMUSG00000079110 Vega:OTTMUSG00000015381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p94; Lp82; Capa3; Capa-3; AI323605
Orthologs
Location:
2 E5; 2 60.31 cM
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (120463593..120504919)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120289329..120330655)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene VPS39 HOPS complex subunit Neighboring gene transmembrane protein 87A Neighboring gene glucosidase, alpha; neutral C Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene zinc finger protein 106 Neighboring gene synaptosomal-associated protein 23

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: Ganc

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
ligase regulator activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex scaffold IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
sodium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
titin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G1 to G0 transition involved in cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
autolysis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to salt stress IDA
Inferred from Direct Assay
more info
PubMed 
muscle structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of satellite cell activation involved in skeletal muscle regeneration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
response to muscle activity ISO
Inferred from Sequence Orthology
more info
 
sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
self proteolysis ISO
Inferred from Sequence Orthology
more info
 
sodium-dependent self proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
T-tubule ISO
Inferred from Sequence Orthology
more info
 
Z disc ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
myofibril ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
calpain-3
Names
CANP 3
calcium-activated neutral proteinase 3
calpain L3
calpain p94
muscle-specific calcium-activated neutral protease 3
skeletal muscle specific calpain p94
NP_001103231.1
NP_001171270.1
NP_031627.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109761.2NP_001103231.1  calpain-3 isoform b

    See identical proteins and their annotated locations for NP_001103231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) has multiple differences, compared to variant a. The resulting protein (isoform b) is shorter and has a distinct N-terminus when it is compared to isoform a.
    Source sequence(s)
    BB202194, BC090661
    Consensus CDS
    CCDS50680.1
    UniProtKB/TrEMBL
    Q0VGP9
    Related
    ENSMUSP00000028748, OTTMUSP00000016399, ENSMUST00000028748, OTTMUST00000036495
    Conserved Domains (5) summary
    PTZ00184
    Location:533671
    PTZ00184; calmodulin; Provisional
    cd00044
    Location:40347
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd00051
    Location:585639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00214
    Location:359515
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cl08302
    Location:616705
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001177799.1NP_001171270.1  calpain-3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks several alternate, in-frame coding exons, compared to variant a. The resulting protein (isoform c) is shorter when it is compared to isoform a.
    Source sequence(s)
    AF127766, BB202194, BC090661, BC139790, BY142198, CN664345
    Consensus CDS
    CCDS50679.1
    UniProtKB/Swiss-Prot
    Q64691
    UniProtKB/TrEMBL
    A4QPE6, Q0VGP9
    Related
    ENSMUSP00000106349, OTTMUSP00000016397, ENSMUST00000110721, OTTMUST00000036493
    Conserved Domains (5) summary
    PTZ00184
    Location:553691
    PTZ00184; calmodulin; Provisional
    cd00044
    Location:63367
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd00051
    Location:605659
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00214
    Location:379535
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cl08302
    Location:636725
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_007601.3NP_031627.2  calpain-3 isoform a

    See identical proteins and their annotated locations for NP_031627.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) is the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AL935121, BB202194, BC090661, BC139790, BY142198, CN664345
    Consensus CDS
    CCDS16620.1
    UniProtKB/Swiss-Prot
    Q64691
    UniProtKB/TrEMBL
    A4QPE6, Q0VGP9
    Related
    ENSMUSP00000028749, OTTMUSP00000016396, ENSMUST00000028749, OTTMUST00000036492
    Conserved Domains (5) summary
    PTZ00184
    Location:645783
    PTZ00184; calmodulin; Provisional
    cd00044
    Location:63415
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd00051
    Location:697751
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00214
    Location:427583
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cl08302
    Location:728817
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    120463593..120504919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    121617948..121659023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)