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Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) [ Mus musculus (house mouse) ]

Gene ID: 12331, updated on 21-May-2016
Official Symbol
Cap1provided by MGI
Official Full Name
CAP, adenylate cyclase-associated protein 1 (yeast)provided by MGI
Primary source
MGI:MGI:88262
See related
Ensembl:ENSMUSG00000028656 Vega:OTTMUSG00000008872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
Orthologs
Location:
4; 4 D1
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (122859048..122886071, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (122536471..122563124, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene predicted gene 12873 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene major facilitator superfamily domain containing 2A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
ameboidal-type cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adenylyl cyclase-associated protein 1
Names
adenylyl cyclase-associated CAP protein, yeast homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301067.1NP_001287996.1  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_001287996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053351, AK137222, AK171388, AL606906
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124
    UniProtKB/TrEMBL
    Q3U0U5, Q3UVJ2
    Related
    ENSMUSP00000068260, OTTMUSP00000009256, ENSMUST00000069533, OTTMUST00000020186
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  2. NM_007598.4NP_031624.2  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_031624.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053351, AK137222, AL606906
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124
    UniProtKB/TrEMBL
    Q3UVJ2
    Related
    ENSMUSP00000101862, OTTMUSP00000009255, ENSMUST00000106255, OTTMUST00000020185
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    122859048..122886071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502695.1XP_006502758.1  

    See identical proteins and their annotated locations for XP_006502758.1

    UniProtKB/Swiss-Prot
    P40124
    Related
    ENSMUSP00000101864, OTTMUSP00000009257, ENSMUST00000106257, OTTMUST00000020187
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  2. XM_006502697.2XP_006502760.1  

    See identical proteins and their annotated locations for XP_006502760.1

    UniProtKB/Swiss-Prot
    P40124
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    121189497..121216051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)