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LEO1 LEO1 homolog, Paf1/RNA polymerase II complex component [ Homo sapiens (human) ]

Gene ID: 123169, updated on 8-May-2016
Official Symbol
LEO1provided by HGNC
Official Full Name
LEO1 homolog, Paf1/RNA polymerase II complex componentprovided by HGNC
Primary source
HGNC:HGNC:30401
See related
Ensembl:ENSG00000166477 HPRD:11231; MIM:610507; Vega:OTTHUMG00000131843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDL
Summary
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
15q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (51938025..51971801, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52230222..52263995, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tropomodulin 3 Neighboring gene UTP6, small subunit (SSU) processome component, homolog (yeast) pseudogene Neighboring gene uncharacterized LOC105370818 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component pseudogene Neighboring gene mitogen-activated protein kinase 6 Neighboring gene ribosomal protein S13 pseudogene 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
    Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemOnce in the nucleus, beta-catenin is recruited to WNT target genes through interaction with TCF/LEF transcription factors. This family, which consists of TCF7 (also known as TCF1), TCF7L1 (also known...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II C-terminal domain phosphoserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Cdc73/Paf1 complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
RNA polymerase-associated protein LEO1
Names
Leo1 Paf1/RNA polymerase II complex component
Leo1, Paf1/RNA polymerase II complex component, homolog
replicative senescence down-regulated leo1-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286430.1NP_001273359.1  RNA polymerase-associated protein LEO1 isoform 2

    See identical proteins and their annotated locations for NP_001273359.1

    Status: VALIDATED

    Source sequence(s)
    AC090971, AK055762, BC018147
    Consensus CDS
    CCDS66767.1
    UniProtKB/Swiss-Prot
    Q8WVC0
    Related
    ENSP00000314610, OTTHUMP00000248654, ENST00000315141, OTTHUMT00000419020
    Conserved Domains (3) summary
    PHA02664
    Location:31168
    PHA02664; hypothetical protein; Provisional
    pfam04004
    Location:387477
    Leo1; Leo1-like protein
    pfam04931
    Location:146275
    DNA_pol_phi; DNA polymerase phi
  2. NM_001323903.1NP_001310832.1  RNA polymerase-associated protein LEO1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090971
  3. NM_001323904.1NP_001310833.1  RNA polymerase-associated protein LEO1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090971
  4. NM_138792.3NP_620147.1  RNA polymerase-associated protein LEO1 isoform 1

    See identical proteins and their annotated locations for NP_620147.1

    Status: VALIDATED

    Source sequence(s)
    AC090971, BC018147
    Consensus CDS
    CCDS10146.1
    UniProtKB/Swiss-Prot
    Q8WVC0
    Related
    ENSP00000299601, OTTHUMP00000162667, ENST00000299601, OTTHUMT00000254791
    Conserved Domains (3) summary
    PHA02664
    Location:31168
    PHA02664; hypothetical protein; Provisional
    pfam04004
    Location:373537
    Leo1; Leo1-like protein
    pfam04931
    Location:146275
    DNA_pol_phi; DNA polymerase phi

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    51938025..51971801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521211.1XP_011519513.1  

    Conserved Domains (3) summary
    PHA02664
    Location:31168
    PHA02664; hypothetical protein; Provisional
    pfam04004
    Location:373537
    Leo1; Leo1-like protein
    pfam04931
    Location:146275
    DNA_pol_phi; DNA polymerase phi

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    52348273..52382049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)