Format

Send to:

Choose Destination

Ddr1 discoidin domain receptor family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 12305, updated on 28-May-2016
Official Symbol
Ddr1provided by MGI
Official Full Name
discoidin domain receptor family, member 1provided by MGI
Primary source
MGI:MGI:99216
See related
Ensembl:ENSMUSG00000003534 Vega:OTTMUSG00000031017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cak; Nep; PTK3A; CD167a; AI323681; 6030432F18
Orthologs
Location:
17 C; 17 18.7 cM
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (35681567..35704629, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35818512..35841084, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene general transcription factor II H, polypeptide 4 Neighboring gene uncharacterized LOC105246271 Neighboring gene RIKEN cDNA 4833427F10 gene Neighboring gene predicted gene, 32409 Neighboring gene immediate early response 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
collagen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase collagen receptor activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
smooth muscle cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
epithelial discoidin domain-containing receptor 1
Names
CD167 antigen-like family member A
cell adhesion kinase
discoidin receptor tyrosine kinase
epithelial discoidin domain receptor 1
protein-tyrosine kinase MPK-6
tyrosine kinase DDR
tyrosine-protein kinase CAK
NP_001185760.1
NP_001185762.1
NP_031610.1
NP_766550.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198831.1NP_001185760.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, CK790776, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    Q05BN5, Q544T2
    Related
    ENSMUSP00000133047, ENSMUST00000166980
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001198833.1NP_001185762.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, BY062785, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    Q05BN5, Q544T2
    Related
    ENSMUSP00000113062, OTTMUSP00000040508, ENSMUST00000119825, OTTMUST00000076831
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  3. NM_007584.2NP_031610.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    Q05BN5, Q544T2
    Related
    ENSMUSP00000003628, ENSMUST00000003628
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  4. NM_172962.1NP_766550.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_766550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (2) than isoform 1.
    Source sequence(s)
    AK143088, BC037108, L57509
    Consensus CDS
    CCDS37603.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    Q05BN5, Q544T2
    Related
    ENSMUSP00000094945, OTTMUSP00000040507, ENSMUST00000097333, OTTMUST00000076829
    Conserved Domains (3) summary
    smart00219
    Location:571866
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    35681567..35704629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523536.2XP_006523599.1  

    See identical proteins and their annotated locations for XP_006523599.1

    UniProtKB/Swiss-Prot
    Q03146
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006523533.1XP_006523596.1  

    See identical proteins and their annotated locations for XP_006523596.1

    UniProtKB/Swiss-Prot
    Q03146
    Related
    ENSMUSP00000112570, OTTMUSP00000040506, ENSMUST00000117301, OTTMUST00000076828
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006523537.1XP_006523600.1  

    See identical proteins and their annotated locations for XP_006523600.1

    UniProtKB/Swiss-Prot
    Q03146
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006523534.1XP_006523597.1  

    See identical proteins and their annotated locations for XP_006523597.1

    UniProtKB/Swiss-Prot
    Q03146
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006523538.2XP_006523601.1  

    See identical proteins and their annotated locations for XP_006523601.1

    UniProtKB/TrEMBL
    Q544T2
    Conserved Domains (3) summary
    smart00219
    Location:571866
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006523535.2XP_006523598.1  

    See identical proteins and their annotated locations for XP_006523598.1

    UniProtKB/Swiss-Prot
    Q03146
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011246259.1XP_011244561.1  

    See identical proteins and their annotated locations for XP_011244561.1

    UniProtKB/Swiss-Prot
    Q03146
    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_385270.2 RNA Sequence

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    1991513..2014484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011251282.1XP_011249584.1  

    See identical proteins and their annotated locations for XP_011249584.1

    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    2015109..2038105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238122.1XP_011236424.1  

    See identical proteins and their annotated locations for XP_011236424.1

    Conserved Domains (3) summary
    smart00219
    Location:608903
    TyrKc; Tyrosine kinase, catalytic domain
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    39195716..39218204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)