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    JDP2 Jun dimerization protein 2 [ Homo sapiens ]

    Gene ID: 122953, updated on 11-May-2012
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    Summary

    Official Symbol
    JDP2provided by HGNC
    Official Full Name
    Jun dimerization protein 2provided by HGNC
    Primary source
    HGNC:17546
    See related
    Ensembl:ENSG00000140044; HPRD:16360; MIM:608657; Vega:OTTHUMG00000171869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JUNDM2
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    Genomic context

    Location :
    14q24.3
    Sequence :
    Chromosome: 14; NC_000014.8 (75894509..75939404)
    See JDP2 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene uncharacterized LOC731223 Neighboring gene basic leucine zipper transcription factor, ATF-like Neighboring gene feline leukemia virus subgroup C cellular receptor family, member 2 Neighboring gene ribosomal protein S24 pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency. Murata T, et al. J Biol Chem, 2011 Jun 24. PMID 21525011.
    2. Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging. Huang YC, et al. Kaohsiung J Med Sci, 2010 Oct. PMID 20950777.
    3. Downregulation of AP-1 repressor JDP2 is associated with tumor metastasis and poor prognosis in patients with pancreatic carcinoma. Yuanhong X, et al. Int J Biol Markers, 2010 Jul-Sep. PMID 20677166.
    4. Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort. Krischek B, et al. Neuroscience, 2010 Aug 11. PMID 20452405.
    5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142.

    See all (23) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
      Title: Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging.
    2. JDP2 is crucial to triggering reactivation from latency to lytic replication
      Title: Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.
    3. 3 SNPs (2 intronic: rs741846 & rs175646; & 1 in the untranslated region: rs8215) & their genotype distribution showed significant association in the Japanese & Korean but not Dutch intracranial aneurysm patients.
      Title: Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort.
    4. JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival.
      Title: Downregulation of AP-1 repressor JDP2 is associated with tumor metastasis and poor prognosis in patients with pancreatic carcinoma.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort.
    6. A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain.
      Title: A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain.
    7. IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter.
      Title: IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription.
    8. JDP2 acts as a repressor and could be functionally associated with HDAC3 to inhibit CHOP transcription
      Title: Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP.
    9. c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene
      Title: The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene.
    10. JDP2 is a cellular survival protein whose presence is necessary for normal cellular function
      Title: Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Jun dimerization protein 2 P15336 ATF2    HPRD  PubMed  
    Jun dimerization protein 2 Q92793 CREBBP    HPRD  PubMed  
    Jun dimerization protein 2 Q09472 EP300    HPRD  PubMed  
    Jun dimerization protein 2 P05412 JUN    HPRD  PubMed  
    Jun dimerization protein 2 P17275 JUNB    HPRD  PubMed  
    Jun dimerization protein 2 P17535 JUND    HPRD  PubMed  
    Jun dimerization protein 2 Q92831 KAT2B    HPRD  PubMed  
    Jun dimerization protein 2 Q16539 MAPK14    HPRD  PubMed  
    Jun dimerization protein 2 P45983 MAPK8    HPRD  PubMed  
    Jun dimerization protein 2 P45984 MAPK9    HPRD  PubMed  
    Jun dimerization protein 2 P06401 PGR    HPRD  PubMed  
    Jun dimerization protein 2 Q13573 SNW1    HPRD  PubMed  
    BioGRID:125807 BioGRID:107776 ATF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:125807 BioGRID:116206 ATF7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:125807 BioGRID:109220 GTF2H1    BioGRID  PubMed Two-hybrid 
    BioGRID:125807 BioGRID:117576 IRF2BP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:125807 BioGRID:125807 JDP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:125807 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:125807 BioGRID:109930 JUND    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:125807 BioGRID:111260 PGR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:125807 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    jun dimerization protein 2
    Names
    jun dimerization protein 2
    progesterone receptor co-activator
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135047.1 → NP_001128519.1  jun dimerization protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC009363, AI916777, BC051303, BU740697
      Consensus CDS
      CCDS9842.1
      UniProtKB/Swiss-Prot
      Q8WYK2
      Related
      ENSP00000415558, OTTHUMP00000246980, ENST00000419727, OTTHUMT00000415501
      Conserved Domains (1) summary
      cl02576
      Location:82 – 134
      Blast Score: 111
      bZIP_1; bZIP transcription factor

    2. NM_001135048.1 → NP_001128520.1  jun dimerization protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC009363, AF111167, BC051303, BE389064, BU740697
      Consensus CDS
      CCDS9842.1
      UniProtKB/Swiss-Prot
      Q8WYK2
      Related
      ENSP00000409787, ENST00000437176
      Conserved Domains (1) summary
      cl02576
      Location:82 – 134
      Blast Score: 111
      bZIP_1; bZIP transcription factor

    3. NM_001135049.1 → NP_001128521.1  jun dimerization protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC009363, BC051303, BU740697
      Consensus CDS
      CCDS45139.1
      UniProtKB/Swiss-Prot
      Q8WYK2
      Related
      ENSP00000267569, OTTHUMP00000246983, ENST00000267569, OTTHUMT00000415506
      Conserved Domains (1) summary
      cl02576
      Location:93 – 145
      Blast Score: 121
      bZIP_1; bZIP transcription factor

    4. NM_130469.3 → NP_569736.1  jun dimerization protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2 and 3 encode the same isoform.
      Source sequence(s)
      AC009363, BC051303, BC068196, BU740697
      Consensus CDS
      CCDS9842.1
      UniProtKB/Swiss-Prot
      Q8WYK2
      Related
      ENSP00000399587, OTTHUMP00000246982, ENST00000435893, OTTHUMT00000415505
      Conserved Domains (1) summary
      cl02576
      Location:82 – 134
      Blast Score: 111
      bZIP_1; bZIP transcription factor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      75894509..75939404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      56063139..56107342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009363.4 AAF21148.1
    genomic AF111167.2 AAC98313.1
    genomic CH471061.1 EAW81231.1
      EAW81232.1
      EAW81233.1
    mRNA AB077880.1 BAB83896.1
    mRNA AI916777.1 None
    mRNA BC051303.1 AAH51303.1
    mRNA BC068196.1 None
    mRNA BE389064.1 None
    mRNA BU740697.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WYK2.1 GenPept UniProtKB/Swiss-Prot:Q8WYK2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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