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Cacnb1 calcium channel, voltage-dependent, beta 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 12295, updated on 8-May-2016
Official Symbol
Cacnb1provided by MGI
Official Full Name
calcium channel, voltage-dependent, beta 1 subunitprovided by MGI
Primary source
MGI:MGI:102522
See related
Ensembl:ENSMUSG00000020882 Vega:OTTMUSG00000002912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAB1; Cchb1; Cchlb1
Orthologs
Location:
11 D; 11 61.5 cM
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (98001508..98022975, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (97864215..97883941, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA cysteine 54 (anticodon GCA) Neighboring gene ADP-ribosylation factor-like 5C Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
high voltage-gated calcium channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
 
protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
voltage-dependent L-type calcium channel subunit beta-1
Names
calcium channel voltage-dependent subunit beta 1
voltage-dependent calcium channel beta1 subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159319.2NP_001152791.1  voltage-dependent L-type calcium channel subunit beta-1 isoform C

    See identical proteins and their annotated locations for NP_001152791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate coding exon, lacks another alternate coding exon, and differs in the 3' UTR and coding sequence compared to variant 5. The resulting isoform (C) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform E.
    Source sequence(s)
    AL591209
    Consensus CDS
    CCDS48899.1
    UniProtKB/Swiss-Prot
    Q8R3Z5
    Related
    ENSMUSP00000103187, OTTMUSP00000002820, ENSMUST00000107562, OTTMUST00000005967
    Conserved Domains (4) summary
    cd12041
    Location:99166
    SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
    pfam00625
    Location:228408
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:5899
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:238409
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. NM_001159320.2NP_001152792.1  voltage-dependent L-type calcium channel subunit beta-1 isoform D

    See identical proteins and their annotated locations for NP_001152792.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 5. The resulting isoform (D) has shorter and distinct N- and C-termini compared to isoform E.
    Source sequence(s)
    AL591209
    Consensus CDS
    CCDS48898.1
    UniProtKB/TrEMBL
    A2A542
    Related
    ENSMUSP00000103186, OTTMUSP00000002819, ENSMUST00000107561, OTTMUST00000005966
    Conserved Domains (4) summary
    cd12041
    Location:52119
    SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
    smart00072
    Location:236407
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:226406
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1152
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  3. NM_001282977.1NP_001269906.1  voltage-dependent L-type calcium channel subunit beta-1 isoform E

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (E).
    Source sequence(s)
    AL591209
    Related
    ENSMUSP00000099433, ENSMUST00000103144
    Conserved Domains (4) summary
    smart00072
    Location:283454
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:273453
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:5899
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:99166
    SH3; Src Homology 3 domain superfamily
  4. NM_001282978.1NP_001269907.1  voltage-dependent L-type calcium channel subunit beta-1 isoform F

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate coding exon, uses an alternate splice junction at the 5' end of an exon, and differs in the 3' UTR and coding sequence compared to variant 5. The resulting isoform (F) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform E.
    Source sequence(s)
    AL591209
    Conserved Domains (4) summary
    cd12041
    Location:99166
    SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
    pfam00625
    Location:220400
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:5899
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:230401
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. NM_031173.4NP_112450.1  voltage-dependent L-type calcium channel subunit beta-1 isoform A

    See identical proteins and their annotated locations for NP_112450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 5. The resulting isoform (A) has a shorter and distinct C-terminus compared to isoform E.
    Source sequence(s)
    AL591209
    Consensus CDS
    CCDS25336.1
    UniProtKB/Swiss-Prot
    Q8R3Z5
    UniProtKB/TrEMBL
    A2A545
    Related
    ENSMUSP00000090412, OTTMUSP00000002818, ENSMUST00000092736, OTTMUST00000005965
    Conserved Domains (4) summary
    cd12041
    Location:99166
    SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
    smart00072
    Location:283454
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:273453
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:5899
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  6. NM_145121.3NP_660099.2  voltage-dependent L-type calcium channel subunit beta-1 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate coding exon and lacks another alternate coding exon compared to variant 5. The resulting isoform (B) has the same N- and C-termini but is shorter compared to isoform E.
    Source sequence(s)
    AL591209
    Consensus CDS
    CCDS25335.1
    UniProtKB/TrEMBL
    A2A543
    Related
    ENSMUSP00000017552, OTTMUSP00000002817, ENSMUST00000017552, OTTMUST00000005964
    Conserved Domains (4) summary
    smart00072
    Location:238409
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:228408
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:5899
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:99166
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    98001508..98022975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532091.2XP_006532154.1  

    Conserved Domains (4) summary
    cd12041
    Location:111178
    SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
    smart00072
    Location:295466
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:285465
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:70111
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  2. XM_006532092.2XP_006532155.1  

    Conserved Domains (4) summary
    cd12041
    Location:111178
    SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
    smart00072
    Location:250421
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:240420
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:70111
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  3. XM_006532094.2XP_006532157.1  

    See identical proteins and their annotated locations for XP_006532157.1

    Conserved Domains (2) summary
    smart00072
    Location:10181
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:1180
    Guanylate_kin; Guanylate kinase

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    107651829..107676228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)