Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cacna2d1provided by MGI
Official Full Name: calcium channel, voltage-dependent, alpha2/delta subunit 1provided by MGI
Primary source: MGI:88295
See related: Ensembl:ENSMUSG00000040118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cacna2; Cchl2a; Ca(v)alpha2delta1
Summary: This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Genomic context

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Location :: 5 A2; 5 6.56 cM

Sequence :: Chromosome: 5; NC_000071.6 (15934691..16374511)

See Cacna2d1 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study of the rabbit ortholog of dihydropyridine-sensitive calcium channel alpha 2 provides N-terminal sequencing evidence of the cleavage junction of the alpha2 and delta subunits from the preprotein
Title: Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides.
This study demonistrated that Cacna2d1 gene expression in mouse dorsal raphe nucleus
Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
The alpha(2) delta(1) subunit, previously described as an L-type auxiliary subunit, complexes with the T-type Ca(v)3.2 (alpha(1H)) subunit in MLO-Y4 cells.
Title: Association of the α(2)δ(1) subunit with Ca(v)3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes.
association of calcium channel alpha2/delta subunit 1 and ATP5b occurs in intracellular membranes and at the plasma membrane of developing muscle cells, where they form a signaling complex capable of accelerating the rate of decline of calcium transients
Title: The calcium channel α2/δ1 subunit interacts with ATP5b in the plasma membrane of developing muscle cells.
Upregulation of alpha(2)/delta subunit of VGCC in the frontal cortex and the limbic forebrain plays a critical role in development of morphine-induced rewarding effect and behavioral sensitization following neuronal plasticity.
Title: Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization.
mechanism of Cavalpha2delta1-mediated spinal sensitization in which elevated Cavalpha2delta1 causes increased pre-synaptic glutamate release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli.
Title: Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity.
The calcium channel alpha2/delta1 subunit in skeletal muscle plays a role in extracellular signalling. The alpha2/delta1 subunit may be crucial for muscle development, muscle repair, and myoblast attachment and migration.
Title: The calcium channel alpha2/delta1 subunit is involved in extracellular signalling.
These results indicate that BZDs examined here have the potential to increase L-type HVCC functions mediated via the enhanced expression of alpha2/delta1 subunit after their sustained exposure.
Title: Up-regulation of L-type high voltage-gated calcium channel subunits by sustained exposure to 1,4- and 1,5-benzodiazepines in cerebrocortical neurons.
alpha(2)-delta Type 1 subunit of voltage-gated calcium channels is the major binding protein for pregabalin in the brain and spinal cord.
Title: Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.

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Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation
Targeted (knock-in) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:198437	BioGRID:200268	Htt		BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Pathways from BioSystems

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Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
Cardiac muscle contraction, organism-specific biosystem (from KEGG)
Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
Cardiac muscle contraction, conserved biosystem (from KEGG)
Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
Dilated cardiomyopathy, conserved biosystem (from KEGG)
Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

General gene information

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Markers

RH126132 (e-PCR)
- UniSTS:162844

D5Mit226 (e-PCR), detects polymorphism
- UniSTS:130358

Cacna2d1 (e-PCR), detects polymorphism
- UniSTS:166208

U73483 (e-PCR)
- UniSTS:159344

NoName (e-PCR)
- UniSTS:235132

Cacna2d1 (e-PCR), detects polymorphism
- UniSTS:498316

Homology

Homologs of the Cacna2d1 gene: The Cacna2d1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
calcium channel activity	IEA Inferred from Electronic Annotation more info
ion channel activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
voltage-gated ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
calcium ion transport	ISO Inferred from Sequence Orthology more info
ion transport	IEA Inferred from Electronic Annotation more info
regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
regulation of ion transmembrane transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
T-tubule	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent calcium channel subunit alpha-2/delta-1

Names: voltage-dependent calcium channel subunit alpha-2/delta-1; dihydropyridine-sensitive calcium channel alpha 2; voltage-gated calcium channel subunit alpha-2/delta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110843.1 → NP_001104313.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a), which is processed into alpha-2a and delta-1 subunits.

Source sequence(s)

AC158586, AK164580, BC115871

Consensus CDS

CCDS51421.1

UniProtKB/Swiss-Prot

O08532

Related

ENSMUSP00000049457, ENSMUST00000039370

Conserved Domains (4) summary

cd01463
Location:239 – 417
Blast Score: 644

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam08473
Location:562 – 652
Blast Score: 420

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:446 – 537
Blast Score: 257

Cache_1; Cache domain

pfam08399
Location:104 – 223
Blast Score: 455

VWA_N; VWA N-terminal
NM_001110844.1 → NP_001104314.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform b preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (b) lacks an exon and contains an alternate exon in the coding region, but maintains the reading frame, compared to variant a. The encoded isoform (b), is shorter than isoform a, and is processed into alpha-2b and delta-1 subunits.

Source sequence(s)

AC158586, AK164580, BC115871

Consensus CDS

CCDS51422.1

UniProtKB/Swiss-Prot

O08532

Related

ENSMUSP00000099117, ENSMUST00000101581

Conserved Domains (4) summary

cd01463
Location:239 – 417
Blast Score: 643

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam08473
Location:543 – 636
Blast Score: 463

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:446 – 531
Blast Score: 252

Cache_1; Cache domain

pfam08399
Location:104 – 223
Blast Score: 455

VWA_N; VWA N-terminal
NM_001110845.1 → NP_001104315.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform c preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (c) contains multiple differences in the coding region, but maintains the reading frame, compared to variant a. The encoded isoform (c) is shorter than isoform a, and is processed into alpha-2c and delta-1 subunits.

Source sequence(s)

AC158586, AK164580, BC115871

Consensus CDS

CCDS51423.1

UniProtKB/Swiss-Prot

O08532

UniProtKB/TrEMBL

Q14BH8

Related

ENSMUSP00000136260, ENSMUST00000180204

Conserved Domains (4) summary

cd01463
Location:239 – 417
Blast Score: 644

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam08473
Location:538 – 631
Blast Score: 463

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:446 – 530
Blast Score: 248

Cache_1; Cache domain

pfam08399
Location:104 – 223
Blast Score: 455

VWA_N; VWA N-terminal
NM_001110846.1 → NP_001104316.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform d preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (d) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant a. The encoded isoform (d) is shorter than isoform a, and is processed into alpha-2d and delta-1 subunits.

Source sequence(s)

AC158586, AK164580, BC115871

UniProtKB/Swiss-Prot

O08532

Conserved Domains (4) summary

cd01463
Location:239 – 417
Blast Score: 643

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam08473
Location:538 – 628
Blast Score: 419

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:446 – 530
Blast Score: 248

Cache_1; Cache domain

pfam08399
Location:104 – 223
Blast Score: 454

VWA_N; VWA N-terminal
NM_009784.2 → NP_033914.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform e preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (e) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter than isoform a, and is processed into alpha-2e and delta-1 subunits.

Source sequence(s)

AC158586, AK164580, BC115871

Consensus CDS

CCDS19096.1

UniProtKB/Swiss-Prot

O08532

Related

ENSMUSP00000077391, ENSMUST00000078272

Conserved Domains (4) summary

cd01463
Location:239 – 417
Blast Score: 643

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam08473
Location:543 – 633
Blast Score: 419

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:446 – 531
Blast Score: 252

Cache_1; Cache domain

pfam08399
Location:104 – 223
Blast Score: 454

VWA_N; VWA N-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

15934691..16374511

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

12936968..13372202

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01042428.1	None
genomic	AAHY01042429.1	None
genomic	AAHY01042430.1	None
genomic	AAHY01042431.1	None
genomic	AAHY01042432.1	None
genomic	AAHY01042433.1	None
genomic	AAHY01042434.1	None
genomic	AAHY01042435.1	None
genomic	AAHY01042436.1	None
genomic	AAHY01042437.1	None
genomic	AAHY01042438.1	None
genomic	AAHY01042439.1	None
genomic	AAHY01042440.1	None
genomic	AAHY01042441.1	None
genomic	AAHY01042442.1	None
genomic	AAHY01042443.1	None
genomic	AAHY01042444.1	None
genomic	AAHY01042445.1	None
genomic	AAHY01042446.1	None
genomic	AAHY01042447.1	None
genomic	AC113590.11	None
genomic	AC158126.7	None
genomic	AC158586.8 (121179..192919)	None
genomic	AC163094.5	None
genomic	AC168850.2	None
genomic	AC169383.2	None
genomic	CH466586.2	EDL03241.1	mixed
		EDL03242.1	mixed
		EDL03243.1	mixed
		EDL03244.1	mixed
		EDL03245.1	mixed
mRNA	AK014825.1	None	C57BL/6J
mRNA	AK036613.1	None	C57BL/6J
mRNA	AK046959.1	None	C57BL/6J
mRNA	AK052898.1	BAC35195.1	C57BL/6J
mRNA	AK053484.1	None	C57BL/6J
mRNA	AK053998.1	None	C57BL/6J
mRNA	AK084101.1	None	C57BL/6J
mRNA	AK163677.1	BAE37454.1	C57BL/6J
mRNA	AK164580.1	None	C57BL/6J
mRNA	BC115871.1	AAI15872.1
mRNA	U73483.1	AAB50138.1
mRNA	U73484.1	AAB50139.1
mRNA	U73485.1	AAB50140.1
mRNA	U73486.1	AAB50141.1
mRNA	U73487.1	AAB50142.1