C4bp complement component 4 binding protein [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: C4bpprovided by MGI
Official Full Name: complement component 4 binding proteinprovided by MGI
Primary source: MGI:88229
Locus tag: AC109283.1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C4bpa; AI195242

Genomic context

Go to the top of the page Help

Location :: 1 E4; 1 56.89 cM

Sequence :: Chromosome: 1; NC_000067.6 (130635921..130661618, complement)

See C4bp in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The cellular uptake of C4BP depends on both heparan sulfate proteoglycans and CD91, involving interactions with positively charged residues within C4BP alpha-chain.
Title: Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein.
a novel function of C4BP as an epididymal secretory protein
Title: Complement C4b-binding protein as a novel murine epididymal secretory protein.
findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor-related protein
Title: Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity.
C4BP prevents premature clearance of protein S and uses this ability to compensate the increased clearance of protein S-S460P.
Title: In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
AAH12257.1	NP_031587.1	Bmpr2		BIND	PubMed	BMPR-II interacts with C4bp.

Pathways from BioSystems

Go to the top of the page Help

Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
Complement and Coagulation Cascades, organism-specific biosystem
Complement and Coagulation Cascades
Complement and coagulation cascades, organism-specific biosystem (from KEGG)
Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Complement and coagulation cascades, conserved biosystem (from KEGG)
Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...

General gene information

Go to the top of the page Help

Markers

D17861 (e-PCR)
- UniSTS:124733

RH126698 (e-PCR)
- UniSTS:167264

AI195242 (e-PCR)
- UniSTS:158847

C4bp (e-PCR), detects polymorphism
- UniSTS:141200

Homology

OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: C4b-binding protein

Names: C4b-binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007576.3 → NP_031602.3 C4b-binding protein precursor

Status: VALIDATED

Source sequence(s)

AK149477, M17122

Consensus CDS

CCDS35700.1

UniProtKB/Swiss-Prot

P08607

Conserved Domains (2) summary

cd00033
Location:181 – 241
Blast Score: 148

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:43 – 299
Blast Score: 362

PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38.p1 C57BL/6J

Range

130635921..130661618, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 NOD/MrkTac

Genomic

NT_187021.1 Reference GRCm38.p1 NOD/MrkTac

Range

308901..321449, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

133259338..133285034, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01010911.1 (9457..35153)	None
genomic	AC109283.8	None
genomic	AC139231.11 (186691..186694)	None
genomic	CH466520.2	EDL39738.1	mixed
		EDL39739.1	mixed
genomic	CU442725.4 (111035..123583)	None	ZRU
genomic	M97289.1	None
mRNA	AB094485.1	BAC75871.1	BALB/c
mRNA	AB094486.1	BAC75872.1
mRNA	AK050344.1	None	C57BL/6J
mRNA	AK136735.1	BAE23113.1	C57BL/6J
mRNA	AK149468.1	BAE28899.1	C57BL/6J
mRNA	AK149477.1	BAE28904.1	C57BL/6J
mRNA	AK162345.1	None	C57BL/6J
mRNA	BC012257.1	AAH12257.1	FVB/N
mRNA	M17122.1	AAA37312.1