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Btrc beta-transducin repeat containing protein [ Mus musculus (house mouse) ]

Gene ID: 12234, updated on 8-May-2016
Official Symbol
Btrcprovided by MGI
Official Full Name
beta-transducin repeat containing proteinprovided by MGI
Primary source
MGI:MGI:1338871
See related
Ensembl:ENSMUSG00000025217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOS; FWD1; Fbw1a; Slimb; b-TrCP; beta-TrCP; Beta-Trcp1; E3RSIkappaB; E3RS-IkappaB
Orthologs
Location:
19; 19 D1
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (45363714..45533343)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45438224..45607833)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102640042 Neighboring gene predicted gene 29595 Neighboring gene predicted gene 28578 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 41855 Neighboring gene predicted gene, 41856 Neighboring gene predicted gene, 19639 Neighboring gene polymerase (DNA directed), lambda

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4123, mKIAA4123

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylated amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of proteasomal protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
F-box/WD repeat-containing protein 1A
Names
E3RSIkappaB
HOS
SCF b-TRCP
beta-TrCP
btrc

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037758.2NP_001032847.2  F-box/WD repeat-containing protein 1A isoform a

    See identical proteins and their annotated locations for NP_001032847.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
    Consensus CDS
    CCDS29860.1
    UniProtKB/Swiss-Prot
    Q3ULA2
    Related
    ENSMUSP00000070728, ENSMUST00000065601
    Conserved Domains (4) summary
    pfam12125
    Location:138177
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:290586
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:303581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:181228
    F-box-like; F-box-like
  2. NM_001286465.1NP_001273394.1  F-box/WD repeat-containing protein 1A isoform a

    See identical proteins and their annotated locations for NP_001273394.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
    Consensus CDS
    CCDS29860.1
    UniProtKB/Swiss-Prot
    Q3ULA2
    Conserved Domains (4) summary
    pfam12125
    Location:138177
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:290586
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:303581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:181228
    F-box-like; F-box-like
  3. NM_001286466.1NP_001273395.1  F-box/WD repeat-containing protein 1A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
    UniProtKB/Swiss-Prot
    Q3ULA2
    Conserved Domains (2) summary
    COG2319
    Location:68364
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:81359
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_009771.3NP_033901.1  F-box/WD repeat-containing protein 1A isoform b

    See identical proteins and their annotated locations for NP_033901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
    Consensus CDS
    CCDS38002.1
    UniProtKB/Swiss-Prot
    Q3ULA2
    Related
    ENSMUSP00000107567, ENSMUST00000111936
    Conserved Domains (4) summary
    pfam12125
    Location:102141
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:254550
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:267545
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:145192
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    45363714..45533343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526607.2XP_006526670.2  

    See identical proteins and their annotated locations for XP_006526670.2

    Conserved Domains (4) summary
    pfam12125
    Location:152191
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:304600
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:317595
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:195242
    F-box-like; F-box-like
  2. XM_006526612.1XP_006526675.1  

    Conserved Domains (4) summary
    pfam12125
    Location:76115
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:228524
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:241519
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:119166
    F-box-like; F-box-like
  3. XM_011247118.1XP_011245420.1  

    See identical proteins and their annotated locations for XP_011245420.1

    Conserved Domains (4) summary
    pfam12125
    Location:152191
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:304600
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:317595
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:195242
    F-box-like; F-box-like
  4. XM_011247119.1XP_011245421.1  

    Conserved Domains (4) summary
    pfam12125
    Location:122161
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:274570
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:287565
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:165212
    F-box-like; F-box-like
  5. XM_006526610.2XP_006526673.2  

    Conserved Domains (4) summary
    pfam12125
    Location:126165
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:278574
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:291569
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:169216
    F-box-like; F-box-like
  6. XM_006526614.2XP_006526677.2  

    Conserved Domains (4) summary
    pfam12125
    Location:96135
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:248544
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:261539
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:139186
    F-box-like; F-box-like
  7. XM_011247122.1XP_011245424.1  

    Conserved Domains (4) summary
    pfam12125
    Location:116155
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:268564
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:281559
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:159206
    F-box-like; F-box-like
  8. XM_011247123.1XP_011245425.1  

    Conserved Domains (4) summary
    pfam12125
    Location:90129
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:242538
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:255533
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:133180
    F-box-like; F-box-like
  9. XM_006526608.1XP_006526671.1  

    Conserved Domains (4) summary
    pfam12125
    Location:112151
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:264560
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:277555
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:155202
    F-box-like; F-box-like
  10. XM_006526613.1XP_006526676.1  

    Conserved Domains (4) summary
    pfam12125
    Location:72111
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:224520
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:237515
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:115162
    F-box-like; F-box-like
  11. XM_011247125.1XP_011245427.1  

    See identical proteins and their annotated locations for XP_011245427.1

    Conserved Domains (4) summary
    pfam12125
    Location:120159
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:272568
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:285563
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:163210
    F-box-like; F-box-like
  12. XM_011247126.1XP_011245428.1  

    See identical proteins and their annotated locations for XP_011245428.1

    Conserved Domains (4) summary
    pfam12125
    Location:120159
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:272568
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:285563
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:163210
    F-box-like; F-box-like
  13. XM_011247127.1XP_011245429.1  

    See identical proteins and their annotated locations for XP_011245429.1

    Conserved Domains (4) summary
    pfam12125
    Location:3978
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:191487
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:204482
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:82129
    F-box-like; F-box-like
  14. XM_011247120.1XP_011245422.1  

    See identical proteins and their annotated locations for XP_011245422.1

    Conserved Domains (4) summary
    pfam12125
    Location:120159
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:272568
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:285563
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:163210
    F-box-like; F-box-like
  15. XM_011247121.1XP_011245423.1  

    Conserved Domains (4) summary
    pfam12125
    Location:117156
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:269565
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:282560
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:160207
    F-box-like; F-box-like
  16. XM_006526615.1XP_006526678.1  

    See identical proteins and their annotated locations for XP_006526678.1

    Conserved Domains (4) summary
    pfam12125
    Location:3978
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:191487
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:204482
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:82129
    F-box-like; F-box-like
  17. XM_011247124.1XP_011245426.1  

    See identical proteins and their annotated locations for XP_011245426.1

    Conserved Domains (4) summary
    pfam12125
    Location:3978
    Beta-TrCP_D; D domain of beta-TrCP
    COG2319
    Location:191487
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:204482
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:82129
    F-box-like; F-box-like

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    46131196..46300930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)