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Btk Bruton agammaglobulinemia tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 12229, updated on 28-May-2016
Official Symbol
Btkprovided by MGI
Official Full Name
Bruton agammaglobulinemia tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:88216
See related
Ensembl:ENSMUSG00000031264 Vega:OTTMUSG00000019307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
xid; AI528679
Orthologs
Location:
X E3; X 56.18 cM
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (134542334..134583623, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (131076880..131117679, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene STAT3-interacting protein as a repressor pseudogene Neighboring gene translocase of inner mitochondrial membrane 8A1 Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to molecule of fungal origin ISO
Inferred from Sequence Orthology
more info
 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I hypersensitivity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type III hypersensitivity ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine-protein kinase BTK
Names
ATK
B-cell progenitor kinase
BPK
Bruton's tyrosine kinase
Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB)
X-linked immune deficiency
agammaglobulinaemia tyrosine kinase
agammaglobulinemia tyrosine kinase
bruton tyrosine kinase
kinase EMB
NP_038510.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013482.2NP_038510.2  tyrosine-protein kinase BTK

    See identical proteins and their annotated locations for NP_038510.2

    Status: VALIDATED

    Source sequence(s)
    BY596531, CJ044967, DT921900, L29788
    Consensus CDS
    CCDS30396.1
    UniProtKB/Swiss-Prot
    P35991
    Related
    ENSMUSP00000033617, OTTMUSP00000020834, ENSMUST00000033617, OTTMUST00000046138
    Conserved Domains (5) summary
    cd05113
    Location:397652
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:274378
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:217271
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    pfam07714
    Location:402651
    Pkinase_Tyr; Protein tyrosine kinase
    cd01238
    Location:6166
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    134542334..134583623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528485.2XP_006528548.1  

    See identical proteins and their annotated locations for XP_006528548.1

    UniProtKB/Swiss-Prot
    P35991
    Conserved Domains (5) summary
    cd05113
    Location:397652
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:274378
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:217271
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    pfam07714
    Location:402651
    Pkinase_Tyr; Protein tyrosine kinase
    cd01238
    Location:6166
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
  2. XM_006528483.2XP_006528546.1  

    See identical proteins and their annotated locations for XP_006528546.1

    UniProtKB/Swiss-Prot
    P35991
    Conserved Domains (5) summary
    cd05113
    Location:397652
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:274378
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:217271
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    pfam07714
    Location:402651
    Pkinase_Tyr; Protein tyrosine kinase
    cd01238
    Location:6166
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
  3. XM_006528484.2XP_006528547.1  

    See identical proteins and their annotated locations for XP_006528547.1

    UniProtKB/Swiss-Prot
    P35991
    Conserved Domains (5) summary
    cd05113
    Location:397652
    PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
    cd10397
    Location:274378
    SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
    cd11906
    Location:217271
    SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
    pfam07714
    Location:402651
    Pkinase_Tyr; Protein tyrosine kinase
    cd01238
    Location:6166
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    117421885..117462725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)