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Birc6 baculoviral IAP repeat-containing 6 [ Mus musculus (house mouse) ]

Gene ID: 12211, updated on 28-May-2016
Official Symbol
Birc6provided by MGI
Official Full Name
baculoviral IAP repeat-containing 6provided by MGI
Primary source
MGI:MGI:1276108
See related
Ensembl:ENSMUSG00000024073 Vega:OTTMUSG00000042370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bruce; AA501170; mKIAA1289; A430032G04Rik; A430040A19Rik; D630005A10Rik
Orthologs
Location:
17; 17 E3
Exon count:
75
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (74528216..74703356)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (74927635..75103113)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene Yip1 domain family, member 4 Neighboring gene predicted gene, 31645 Neighboring gene tetratricopeptide repeat domain 27 Neighboring gene predicted gene, 41618 Neighboring gene predicted gene, 31759 Neighboring gene predicted gene, 31818

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
    Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis - multiple species, conserved biosystem (from KEGG)
    Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IC
Inferred by Curator
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
spongiotrophoblast layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
midbody ISO
Inferred from Sequence Orthology
more info
 
spindle pole ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
baculoviral IAP repeat-containing protein 6
Names
BIR repeat-containing ubiquitin-conjugating enzyme
apollon
baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme
baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6
ubiquitin-conjugating BIR domain enzyme apollon

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007566.3NP_031592.3  baculoviral IAP repeat-containing protein 6

    Status: VALIDATED

    Source sequence(s)
    AC098726, AC154442, AK041241, AK042247, AK045446, AK052612, AK134254, AK173143, BG695066, CN536181, CN707067, CO424370, DV651019
    Consensus CDS
    CCDS37693.2
    UniProtKB/Swiss-Prot
    O88738
    UniProtKB/TrEMBL
    Q3UYZ6
    Related
    ENSMUSP00000136329, OTTMUSP00000062557, ENSMUST00000180037, OTTMUST00000111659
    Conserved Domains (3) summary
    cd00022
    Location:290363
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46134751
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:34773632
    DUF3643; Protein of unknown function (DUF3643)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    74528216..74703356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523529.2XP_006523592.1  

    Conserved Domains (1) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
  2. XM_011246257.1XP_011244559.1  

    Conserved Domains (2) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    pfam12356
    Location:35573712
    DUF3643; Protein of unknown function (DUF3643)
  3. XM_006523518.1XP_006523581.1  

    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46934831
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35573712
    DUF3643; Protein of unknown function (DUF3643)
  4. XM_006523520.1XP_006523583.1  

    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46874825
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35513706
    DUF3643; Protein of unknown function (DUF3643)
  5. XM_006523522.1XP_006523585.1  

    Related
    ENSMUSP00000138270, OTTMUSP00000063933, ENSMUST00000183224, OTTMUST00000114560
    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46844822
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35483703
    DUF3643; Protein of unknown function (DUF3643)
  6. XM_006523524.1XP_006523587.1  

    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46784816
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35423697
    DUF3643; Protein of unknown function (DUF3643)
  7. XM_006523521.1XP_006523584.1  

    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46874825
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35513706
    DUF3643; Protein of unknown function (DUF3643)
  8. XM_006523527.1XP_006523590.1  

    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46604798
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35243679
    DUF3643; Protein of unknown function (DUF3643)
  9. XM_006523519.1XP_006523582.1  

    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46894827
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35533708
    DUF3643; Protein of unknown function (DUF3643)
  10. XM_006523523.2XP_006523586.1  

    Related
    ENSMUSP00000138333, OTTMUSP00000063931, ENSMUST00000182597, OTTMUST00000114557
    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46794817
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35433698
    DUF3643; Protein of unknown function (DUF3643)
  11. XM_006523526.2XP_006523589.1  

    Related
    ENSMUSP00000138732, OTTMUSP00000063930, ENSMUST00000182944, OTTMUST00000114556
    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46664804
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35303685
    DUF3643; Protein of unknown function (DUF3643)
  12. XM_006523528.2XP_006523591.1  

    Conserved Domains (3) summary
    cd00022
    Location:347420
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd00195
    Location:46494787
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    pfam12356
    Location:35133668
    DUF3643; Protein of unknown function (DUF3643)

RNA

  1. XR_385268.2 RNA Sequence

  2. XR_385267.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    78838153..79014231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)