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Bmp4 bone morphogenetic protein 4 [ Mus musculus (house mouse) ]

Gene ID: 12159, updated on 18-Oct-2014
Official Symbol
Bmp4provided by MGI
Official Full Name
bone morphogenetic protein 4provided by MGI
Primary source
MGI:MGI:88180
Locus tag
RP23-87H19.2
See related
Ensembl:ENSMUSG00000021835; Vega:OTTMUSG00000019526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1
See Bmp4 in Epigenomics, MapViewer
Location:
14 C1; 14 23.95 cM
Exon count:
6
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (46383520..46390599, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene ubiquitin pseudogene Neighboring gene uncharacterized LOC102637772 Neighboring gene uncharacterized LOC102638002 Neighboring gene predicted gene 15217 Neighboring gene uncharacterized LOC102638118 Neighboring gene uncharacterized LOC102638201

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Elastic fibre formation, organism-specific biosystem (from REACTOME)
    Elastic fibre formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Heart Development, organism-specific biosystem (from WikiPathways)
    Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Molecules associated with elastic fibres, organism-specific biosystem (from REACTOME)
    Molecules associated with elastic fibres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
    PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
BMP receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
BMP signaling pathway involved in heart induction ISO
Inferred from Sequence Orthology
more info
 
BMP signaling pathway involved in nephric duct formation ISO
Inferred from Sequence Orthology
more info
 
BMP signaling pathway involved in renal system segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
BMP signaling pathway involved in ureter morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
anatomical structure formation involved in morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel development IDA
Inferred from Direct Assay
more info
PubMed 
blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
bone development IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
bronchus development ISO
Inferred from Sequence Orthology
more info
PubMed 
bud dilation involved in lung branching ISO
Inferred from Sequence Orthology
more info
PubMed 
bud elongation involved in lung branching IDA
Inferred from Direct Assay
more info
PubMed 
camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 
common-partner SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
cranial suture morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
deltoid tuberosity development IMP
Inferred from Mutant Phenotype
more info
 
dorsal/ventral neural tube patterning IDA
Inferred from Direct Assay
more info
PubMed 
embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal joint morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endochondral ossification IMP
Inferred from Mutant Phenotype
more info
 
epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial tube branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial-mesenchymal cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
epithelium development IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
NOT eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
glomerular capillary formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth IEA
Inferred from Electronic Annotation
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
inner ear receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
intermediate mesodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
 
lens induction in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
mammary gland formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal cell differentiation involved in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal cell differentiation involved in renal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
mesoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
mesodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
mesodermal cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephros development IDA
Inferred from Direct Assay
more info
PubMed 
metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell proliferation involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glomerulus development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mesenchymal cell proliferation involved in ureter development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of metanephric S-shaped body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of metanephric comma-shaped body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of prostatic bud formation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of prostatic bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neural tube closure IDA
Inferred from Direct Assay
more info
PubMed 
neuron fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth IDA
Inferred from Direct Assay
more info
PubMed 
odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
organ induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 
positive regulation of DNA-dependent DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hepatocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of kidney development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 
positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
pulmonary artery endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cartilage development IDA
Inferred from Direct Assay
more info
 
regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of morphogenesis of a branching structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of smooth muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
renal system development IGI
Inferred from Genetic Interaction
more info
 
renal system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
secondary heart field specification ISO
Inferred from Sequence Orthology
more info
 
skeletal system development IDA
Inferred from Direct Assay
more info
PubMed 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
specification of organ position IMP
Inferred from Mutant Phenotype
more info
PubMed 
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
telencephalon development ISO
Inferred from Sequence Orthology
more info
PubMed 
telencephalon regionalization IDA
Inferred from Direct Assay
more info
PubMed 
telencephalon regionalization IGI
Inferred from Genetic Interaction
more info
PubMed 
tendon cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
trachea development ISO
Inferred from Sequence Orthology
more info
PubMed 
trachea formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
ureter epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureter smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureteric bud development IDA
Inferred from Direct Assay
more info
PubMed 
ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane-bounded vesicle ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
bone morphogenetic protein 4
Names
bone morphogenetic protein 4
bone morphogenetic protein 2B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007554.2NP_031580.2  bone morphogenetic protein 4 precursor

    See proteins identical to NP_031580.2

    Status: VALIDATED

    Source sequence(s)
    AK136527, CT009556
    Consensus CDS
    CCDS36897.1
    UniProtKB/Swiss-Prot
    P21275
    UniProtKB/TrEMBL
    Q3ULR1
    Related
    ENSMUSP00000073720, OTTMUSP00000021065, ENSMUST00000074077, OTTMUST00000046636
    Conserved Domains (2) summary
    smart00204
    Location:308408
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:36276
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    46383520..46390599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518467.1XP_006518530.1  

    See proteins identical to XP_006518530.1

    UniProtKB/Swiss-Prot
    P21275
    UniProtKB/TrEMBL
    Q3ULR1
    Conserved Domains (2) summary
    smart00204
    Location:308408
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:36276
    TGFb_propeptide; TGF-beta propeptide
  2. XM_006518468.1XP_006518531.1  

    See proteins identical to XP_006518531.1

    UniProtKB/Swiss-Prot
    P21275
    UniProtKB/TrEMBL
    Q3ULR1
    Conserved Domains (2) summary
    smart00204
    Location:308408
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:36276
    TGFb_propeptide; TGF-beta propeptide

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    42555453..42562519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)