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Bmp4 bone morphogenetic protein 4 [ Mus musculus (house mouse) ]

Gene ID: 12159, updated on 15-Jun-2013

Summary

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Official Symbol: Bmp4provided by MGI
Official Full Name: bone morphogenetic protein 4provided by MGI
Primary source: MGI:88180
Locus tag: RP23-87H19.2
See related: Ensembl:ENSMUSG00000021835; Vega:OTTMUSG00000019526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1

Genomic context

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Location :: 14 C1; 14 23.95 cM

Sequence :: Chromosome: 14; NC_000080.6 (46383520..46390599, complement)

See Bmp4 in Epigenomics, MapViewer

Chromosome 14 - NC_000080.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ctnnb1 in UGS basal epithelial cell differentiation, prostatic bud initiation and bud spacing
Title: Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning.
COCH is a part of the downstream target network of BMP4 signaling and serves as another important effector to fine-tune mouse embryonic stem cell fates.
Title: BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells.
These findings provide a genetic and metabolic basis for BMP4's role in altering insulin sensitivity by affecting white adipose tissue development.
Title: BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis.
Adding exogenous BMP4 to culture medium could differentiate pluripotent stage-specific embryonic antigen-1+ cells isolated from an adult tissue into gamete precursors, primordial germ cells.
Title: BMP4 can generate primordial germ cells from bone-marrow-derived pluripotent stem cells.
Foxc1 sets a threshold for the Bmp-dependent activation of Msx2, thus controlling the differentiation of osteogenic precursor cells and the rate and pattern of calvarial bone development.
Title: Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2.
we conclude that BMP4 is a mediator and novel therapeutic target for pathological cardiac hypertrophy.
Title: Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy.
In HSPCs, BMP4 directly regulates Integrin-alpha4 expression through SMAD-independent p38 MAPK-mediated signaling.
Title: A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression.
The glycosaminoglycans chains of biglycan (BGN) promote BGN-assisted BMP-4 function.
Title: Glycosaminoglycan chains of biglycan promote bone morphogenetic protein-4-induced osteoblast differentiation.
GATA-2 expression in the caudal urogenital mesenchyme as directed by the UG4 enhancer is crucial for proper development of the urinary tract and that its regulation of BMP4 expression is a critical aspect of this function
Title: UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice.
Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation
Title: Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.

Submit: New GeneRIF Correction See all (202)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (4) 1 citation
Targeted (knock-out) (3) 1 citation
Targeted (Reporter) (5) 1 citation
Targeted (knock-in) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_031580.1	NP_031586.1	Bmpr1b	BIND	PubMed	BMP4 interacts with the ectodomain BMPR1B. This interaction was modelled on a demonstrated interaction between human BMP4 and human BMPR1B.
NP_031580.1	NP_598470.2	Chrdl2	BIND	PubMed	BMP4 interacts with Chl2. This interaction was modelled on a demonstrated interaction between human BMP4 and mouse Chl2.
NP_031580.1	NP_032072.1	Fst	BIND	PubMed	Fst interacts with Bmp4. This interaction was modelled on a demonstrated interaction between human follistatin and mouse Bmp4.
NP_031580.1	NP_062510.1	Htra1	BIND	PubMed	Prss11 interacts with Bmp4.
NP_031580.1	NP_079588.1	Sostdc1	BIND	PubMed	BMP4 interacts with ectodin. This interaction was modeled on a demonstrated interaction between human BMP4 and mouse ectodin.
BioGRID:198364	BioGRID:215850	Bmper	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198364	BioGRID:213242	Chrdl2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198364	BioGRID:207847	Htra1	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
Basal cell carcinoma, organism-specific biosystem (from KEGG)
Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
Basal cell carcinoma, conserved biosystem (from KEGG)
Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
Elastic fibre formation, organism-specific biosystem (from REACTOME)
Elastic fibre formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Heart Development, organism-specific biosystem (from WikiPathways)
Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
Hedgehog signaling pathway, conserved biosystem (from KEGG)
Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
Hippo signaling pathway, organism-specific biosystem (from KEGG)
Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Hippo signaling pathway, conserved biosystem (from KEGG)
Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
Molecules associated with elastic fibres, organism-specific biosystem (from REACTOME)
Molecules associated with elastic fibres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

UniSTS:496641 (e-PCR)
- UniSTS:496641

Bmp4 (e-PCR), detects polymorphism
- UniSTS:496641

D14Mit129 (e-PCR), detects polymorphism
- UniSTS:127234

RH94860 (e-PCR)
- UniSTS:120106

BMP4_296 (e-PCR)
- UniSTS:277036

PMC156609P1 (e-PCR)
- UniSTS:271413

Bmp4 (e-PCR), detects polymorphism
- UniSTS:532293

PMC316400P2 (e-PCR)
- UniSTS:272980

PMC316400P3 (e-PCR)
- UniSTS:272981

Bmp4 (e-PCR), detects polymorphism
- UniSTS:141181

UniSTS:497280 (e-PCR)
- UniSTS:497280

Bmp4 (e-PCR), detects polymorphism
- UniSTS:497280

Bmp4 (e-PCR), detects polymorphism
- UniSTS:506753

Bmp4 (e-PCR), detects polymorphism
- UniSTS:532664

Bmp4 (e-PCR), detects polymorphism
- UniSTS:265413

Bmp4 (e-PCR), detects polymorphism
- UniSTS:207058

Bmp4 (e-PCR), detects polymorphism
- UniSTS:478950

Bmp4 (e-PCR), detects polymorphism
- UniSTS:526068

MARC_5761-5762:996690803:2 (e-PCR)
- UniSTS:269563

Homology

Homologs of the Bmp4 gene: The Bmp4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
BMP receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
chemoattractant activity	ISO Inferred from Sequence Orthology more info
cytokine activity	ISO Inferred from Sequence Orthology more info
growth factor activity	ISO Inferred from Sequence Orthology more info
heparin binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
BMP signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
BMP signaling pathway involved in heart induction	ISO Inferred from Sequence Orthology more info
BMP signaling pathway involved in nephric duct formation	ISO Inferred from Sequence Orthology more info
BMP signaling pathway involved in renal system segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
BMP signaling pathway involved in ureter morphogenesis	IDA Inferred from Direct Assay more info	PubMed
SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
activation of MAPKK activity	ISO Inferred from Sequence Orthology more info
anatomical structure formation involved in morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
anterior/posterior axis specification	IGI Inferred from Genetic Interaction more info	PubMed
blood vessel development	IDA Inferred from Direct Assay more info	PubMed
blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
bone development	IDA Inferred from Direct Assay more info	PubMed
branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
branching involved in ureteric bud morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
bronchus development	ISO Inferred from Sequence Orthology more info	PubMed
bud dilation involved in lung branching	ISO Inferred from Sequence Orthology more info	PubMed
bud elongation involved in lung branching	IDA Inferred from Direct Assay more info	PubMed
camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cartilage development	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info
common-partner SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
cranial suture morphogenesis	IDA Inferred from Direct Assay more info	PubMed
deltoid tuberosity development	IMP Inferred from Mutant Phenotype more info
dorsal/ventral neural tube patterning	IDA Inferred from Direct Assay more info	PubMed
embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic digit morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic hindlimb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic skeletal joint morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic skeletal joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
endochondral ossification	IMP Inferred from Mutant Phenotype more info
epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
epithelial-mesenchymal cell signaling	IDA Inferred from Direct Assay more info	PubMed
epithelium development	IDA Inferred from Direct Assay more info	PubMed
erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
NOT eye development	IGI Inferred from Genetic Interaction more info	PubMed
forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
glomerular capillary formation	IMP Inferred from Mutant Phenotype more info	PubMed
growth	IEA Inferred from Electronic Annotation more info
heart development	IMP Inferred from Mutant Phenotype more info	PubMed
hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
inner ear receptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
intermediate mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
kidney development	IGI Inferred from Genetic Interaction more info	PubMed
kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
kidney development	ISO Inferred from Sequence Orthology more info
lens induction in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
lung alveolus development	ISO Inferred from Sequence Orthology more info	PubMed
lung development	IMP Inferred from Mutant Phenotype more info	PubMed
lung morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
lymphoid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
macrophage differentiation	ISO Inferred from Sequence Orthology more info
mammary gland formation	IMP Inferred from Mutant Phenotype more info	PubMed
mesenchymal cell differentiation involved in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
mesenchymal cell differentiation involved in renal system development	IMP Inferred from Mutant Phenotype more info	PubMed
mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
mesoderm formation	IDA Inferred from Direct Assay more info	PubMed
mesodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
mesodermal cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
metanephric collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
metanephros development	IDA Inferred from Direct Assay more info	PubMed
metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
monocyte differentiation	ISO Inferred from Sequence Orthology more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
negative regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
negative regulation of cell death	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
negative regulation of cell proliferation involved in heart morphogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
negative regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of glomerulus development	ISO Inferred from Sequence Orthology more info
negative regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
negative regulation of mesenchymal cell proliferation involved in ureter development	ISO Inferred from Sequence Orthology more info
negative regulation of metanephric S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of metanephric comma-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of mitosis	ISO Inferred from Sequence Orthology more info
negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of prostatic bud formation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of prostatic bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
negative regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info	PubMed
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
neural tube closure	IDA Inferred from Direct Assay more info	PubMed
neuron fate commitment	IDA Inferred from Direct Assay more info	PubMed
neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
odontogenesis	ISO Inferred from Sequence Orthology more info
odontogenesis of dentin-containing tooth	IDA Inferred from Direct Assay more info	PubMed
odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
organ induction	IMP Inferred from Mutant Phenotype more info	PubMed
ossification	IEA Inferred from Electronic Annotation more info
osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
osteoblast differentiation	ISO Inferred from Sequence Orthology more info
ovarian follicle development	ISO Inferred from Sequence Orthology more info
pituitary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
positive chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info
positive regulation of DNA-dependent DNA replication	ISO Inferred from Sequence Orthology more info
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of SMAD protein import into nucleus	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
positive regulation of branching involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of cardiac muscle fiber development	ISO Inferred from Sequence Orthology more info
positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of cell death	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell differentiation	IDA Inferred from Direct Assay more info
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	TAS Traceable Author Statement more info
positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info
positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of kidney development	ISO Inferred from Sequence Orthology more info
positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
positive regulation of ossification	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of pathway-restricted SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info
positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info
post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
post-embryonic development	ISO Inferred from Sequence Orthology more info	PubMed
prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
protein localization to nucleus	ISO Inferred from Sequence Orthology more info
pulmonary artery endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
regulation of branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cartilage development	IDA Inferred from Direct Assay more info
regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
regulation of endothelial cell proliferation	TAS Traceable Author Statement more info
regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of morphogenesis of a branching structure	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
regulation of pathway-restricted SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
regulation of smooth muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
renal system development	IGI Inferred from Genetic Interaction more info
renal system process	IMP Inferred from Mutant Phenotype more info	PubMed
secondary heart field specification	ISO Inferred from Sequence Orthology more info
skeletal system development	IDA Inferred from Direct Assay more info	PubMed
skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
smooth muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
specification of organ position	IMP Inferred from Mutant Phenotype more info	PubMed
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway	ISO Inferred from Sequence Orthology more info
steroid hormone mediated signaling pathway	ISO Inferred from Sequence Orthology more info
telencephalon development	ISO Inferred from Sequence Orthology more info	PubMed
telencephalon regionalization	IDA Inferred from Direct Assay more info	PubMed
telencephalon regionalization	IGI Inferred from Genetic Interaction more info	PubMed
tendon cell differentiation	IMP Inferred from Mutant Phenotype more info
tissue development	IGI Inferred from Genetic Interaction more info	PubMed
trachea development	ISO Inferred from Sequence Orthology more info	PubMed
trachea formation	IMP Inferred from Mutant Phenotype more info	PubMed
type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
ureter epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
ureter smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
ureteric bud development	IDA Inferred from Direct Assay more info	PubMed
ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
ureteric bud development	ISO Inferred from Sequence Orthology more info
vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
extracellular region	IDA Inferred from Direct Assay more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
membrane-bounded vesicle	ISO Inferred from Sequence Orthology more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone morphogenetic protein 4

Names: bone morphogenetic protein 4; bone morphogenetic protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007554.2 → NP_031580.2 bone morphogenetic protein 4 precursor

Status: VALIDATED

Source sequence(s)

AK136527, CT009556

Consensus CDS

CCDS36897.1

UniProtKB/Swiss-Prot

P21275

UniProtKB/TrEMBL

Q3ULR1

Related

ENSMUSP00000073720, OTTMUSP00000021065, ENSMUST00000074077, OTTMUST00000046636

Conserved Domains (2) summary

smart00204
Location:308 – 408
Blast Score: 472

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:36 – 276
Blast Score: 548

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000080.6 Reference GRCm38.p1 C57BL/6J

Range

46383520..46390599, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000036.1 Alternate Mm_Celera

Range

42555453..42562519, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01113400.1 (28537..35603)	None
genomic	CH466605.1	EDL20710.1	mixed
		EDL20711.1	mixed
		EDL20712.1	mixed
genomic	CT009556.7 (41715..48794)	None
genomic	D14814.1	BAA03555.1	DBA/2J
genomic	L47480.1	AAC37698.1	129/Sv
mRNA	AK136527.1	BAE23027.1	C57BL/6J
mRNA	AK145359.1	BAE26387.1	C57BL/6J
mRNA	BC013459.1	AAH13459.1	FVB/N
mRNA	BC034053.1	AAH34053.1	FVB/N
mRNA	BC052846.1	AAH52846.1	C3H/He
mRNA	X56848.1	CAA40179.1	C57BL