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    Bmi1 Bmi1 polycomb ring finger oncogene [ Mus musculus (house mouse) ]

    Gene ID: 12151, updated on 9-May-2013
    Official Symbol
    Bmi1provided by MGI
    Official Full Name
    Bmi1 polycomb ring finger oncogeneprovided by MGI
    Primary source
    MGI:88174
    Locus tag
    RP23-396N6.2
    See related
    Ensembl:ENSMUSG00000026739; Vega:OTTMUSG00000011429
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmi-1; Pcgf4; AW546694
    Location :
    2 A3; 2 12.9 cM
    Sequence :
    Chromosome: 2; NC_000068.7 (18677018..18686629)
    See Bmi1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene aminoadipate-semialdehyde dehydrogenase pseudogene Neighboring gene COMM domain containing 3 Neighboring gene uncharacterized LOC101055977 Neighboring gene cDNA sequence BC061194

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NP_031578.2 NP_061244.1 Phc2    BIND  PubMed Bmi1 interacts with Mph2. 
    NP_031578.2 NP_035407.1 Rnf2    BIND  PubMed Ring1B interacts with Bmi1. 
    BioGRID:198359 BioGRID:114105 CBX4    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:198359 BioGRID:121487 CBX8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:198359 BioGRID:198525 Cbfb    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198359 BioGRID:198535 Cbx2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:198359 BioGRID:198654 Cdkn2a    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:198359 BioGRID:211314 Dmap1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:198359 BioGRID:199262 Dnmt3b    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198359 BioGRID:199843 Gata6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198359 BioGRID:113934 HIST2H2AC    BioGRID  PubMed Biochemical Activity 
    BioGRID:198359 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:198359 BioGRID:205978 Kdm2b    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:198359 BioGRID:225038 Mph1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198359 BioGRID:108233 PHC1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:198359 BioGRID:108234 PHC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:198359 BioGRID:123068 PHC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:198359 BioGRID:199382 Phc1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:198359 BioGRID:207636 Phc2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198359 BioGRID:232356 Phc3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:198359 BioGRID:111947 RING1    BioGRID  PubMed Affinity Capture-MS; Co-purification; Two-hybrid 
    BioGRID:198359 BioGRID:111972 RNF2    BioGRID  PubMed Two-hybrid 
    BioGRID:198359 BioGRID:202919 Rnf2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:198359 BioGRID:198519 Runx1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:198359 BioGRID:116609 SCMH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:198359 BioGRID:114045 SMARCA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:198359 BioGRID:201840 Slc11a1    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
     
    contributes_to ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of immature T cell proliferation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ubiquitin-protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    rostrocaudal neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    polycomb complex protein BMI-1
    Names
    polycomb complex protein BMI-1
    polycomb group ring finger 4
    B lymphoma Mo-MLV insertion region 1
    polycomb group RING finger protein 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007552.4NP_031578.2  polycomb complex protein BMI-1

      Status: PROVISIONAL

      Source sequence(s)
      AL928680
      Consensus CDS
      CCDS15711.1
      UniProtKB/Swiss-Prot
      P25916
      UniProtKB/TrEMBL
      Q2LC58
      Related
      ENSMUSP00000028071, OTTMUSP00000012215, ENSMUST00000028071, OTTMUST00000026762
      Conserved Domains (2) summary
      cd00162
      Location:1756
      Blast Score: 112
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:1656
      Blast Score: 130
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p1 C57BL/6J

      Range
      18677018..18686629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      18564450..18578495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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