RHEBL1 Ras homolog enriched in brain like 1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: RHEBL1provided by HGNC
Official Full Name: Ras homolog enriched in brain like 1provided by HGNC
Primary source: HGNC:21166
See related: Ensembl:ENSG00000167550; HPRD:15245; Vega:OTTHUMG00000170407
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RHEBL1c; FLJ25797; MGC34869

Help top of page

Genomic context

Location :: 12q13.12

Sequence :: Chromosome: 12; NC_000012.11 (49458468..49463775, complement)

See RHEBL1 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RHEBL1 is a positive regulator of NF-kappa B-mediated gene transcription.
Title: Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B.
Data show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal, and identify critical residues in Rheb and RhebL1 which are required for their efficient activation of mTOR signaling.
Title: Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Ras homolog enriched in brain like 1	Q04771	ACVR1	HPRD	PubMed
Ras homolog enriched in brain like 1	P31749	AKT1	HPRD	PubMed
Ras homolog enriched in brain like 1	O00238	BMPR1B	HPRD	PubMed
Ras homolog enriched in brain like 1	Q13541	EIF4EBP1	HPRD	PubMed
Ras homolog enriched in brain like 1	P42345	MTOR	HPRD	PubMed
Ras homolog enriched in brain like 1	Q15797	SMAD1	HPRD	PubMed
Ras homolog enriched in brain like 1	Q15796	SMAD2	HPRD	PubMed
Ras homolog enriched in brain like 1	Q13485	SMAD4	HPRD	PubMed
Ras homolog enriched in brain like 1	P36897	TGFBR1	HPRD	PubMed
Ras homolog enriched in brain like 1	P83876	TXNL4A	HPRD	PubMed
BioGRID:125715	BioGRID:116113	TXNL4A	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
GTP binding	IDA Inferred from Direct Assay more info	PubMed
GTPase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
TOR signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: GTPase RhebL1

Names: GTPase RhebL1; rheb2; rheb-like protein 1; Ras homolog enriched in brain like 1 c; ras homolog enriched in brain like-1 c; ras homolog enriched in brain-like protein 1

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144593.1 → NP_653194.1 GTPase RhebL1 precursor

Status: PROVISIONAL

Source sequence(s)

BC027482

Consensus CDS

CCDS8778.1

UniProtKB/Swiss-Prot

Q8TAI7

Related

ENSP00000301068, OTTHUMP00000243723, ENST00000301068, OTTHUMT00000408969

Conserved Domains (1) summary

cd04137
Location:6 – 183
Blast Score: 759

RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

49458468..49463775, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

46490034..46495252, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011603.37 (88926..94233)	None
genomic	CH471111.1	EAW58037.1
		EAW58038.1
mRNA	AK098663.1	BAC05370.1
mRNA	AY327412.1	AAP92804.1
mRNA	AY509932.1	AAS80166.1
mRNA	BC014155.2	AAH14155.1
mRNA	BC027482.1	AAH27482.1