Bcl2l11 BCL2-like 11 (apoptosis facilitator) [Mus musculus] - Gene

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Summary

Official Symbol: Bcl2l11provided by MGI
Official Full Name: BCL2-like 11 (apoptosis facilitator)provided by MGI
Primary source: MGI:1197519
Locus tag: RP23-134I15.1
See related: Ensembl:ENSMUSG00000027381; Vega:OTTMUSG00000015356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bim; Bod; 1500006F24Rik

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Genomic context

Location :: 2; 2 F3-G1

Sequence :: Chromosome: 2; NC_000068.7 (128126038..128162547)

See Bcl2l11 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways.
Title: Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways.
Bim is required for clonal deletion to tissue-restricted antigens.
Title: Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens.
The study identifies the Bim axis as a novel target in the treatment of APAP-induced liver damage and substantiates its general role in hepatocyte death.
Title: Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage.
Bim has a dual role in the development of lymphocytic choriomeningitis virus (LCMV)-induced, T cell-mediated hepatitis.
Title: The proapoptotic Bcl-2 family member Bim plays a central role during the development of virus-induced hepatitis.
Data show that glomeruli isolated from diabetic db/db mice have increased acetylation of Foxo4, suppressed expression of Sirt1, and increased expression of Bcl2l11 compared to non-diabetic littermates.
Title: Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus.
Regulatory T cells (Tregs) can suppress the proliferation of Bim-deficient conventional T cells in a manner largely indistinguishable from wild-type conventional T cells.
Title: Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways.
the balance between Mcl-1 and Bim is a key factor regulating beta cell survival during diabetogenic viral infections.
Title: Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.
Cytokines tumor necrosis factor-alpha and interferon-gamma induce pancreatic beta-cell apoptosis through STAT1-mediated Bim protein activation.
Title: Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
loss of both Bim and Fas function dramatically increased antigen-specific CD8(+) T cells in the lymph nodes following acute lymphocytic choriomeningitis virus (LCMV) infection
Title: Defects in apoptosis increase memory CD8+ T cells following infection of Bim-/-Faslpr/lpr mice.
Bim and Puma expression is induced by endogenous ROS in a SIRT1-dependent manner.
Title: SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells.

Submit: New GeneRIF Correction See all (136)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (4) 1 citation
Targeted (other) (1) 1 citation
Targeted (Reporter) (2) 1 citation
Targeted (knock-in) (5) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
AAC40030.1	NP_033872.1	Bcl2a1a	BIND	PubMed	Bim interacts with A1.
AAC40030.1	NP_031588.1	Bnc1	BIND	PubMed	Bim interacts with Mcl-1.
NP_033884.1	NP_033871.1	Bcl2	BIND	PubMed	BCL-2 interacts with BIM
NP_033884.1	NP_032588.1	Mcl1	BIND	PubMed	MCL-1 interacts with BIM
BioGRID:198352	BioGRID:107068	BCL2	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide; Two-hybrid
BioGRID:198352	BioGRID:107069	BCL2A1	BioGRID	PubMed	Protein-peptide; Two-hybrid
BioGRID:198352	BioGRID:107070	BCL2L1	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide; Two-hybrid
BioGRID:198352	BioGRID:107071	BCL2L2	BioGRID	PubMed	Protein-peptide
BioGRID:198352	BioGRID:198323	Bcl2l1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198352	BioGRID:114206	DYNLL1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Two-hybrid
BioGRID:198352	BioGRID:110338	MCL1	BioGRID	PubMed	Protein-peptide; Two-hybrid
BioGRID:198352	BioGRID:219833	Trim2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198352	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198352	BioGRID:207648	Ywhab	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
microtubule binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
B cell apoptosis	IGI Inferred from Genetic Interaction more info	PubMed
B cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
T cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cellular process regulating host cell cycle in response to virus	IDA Inferred from Direct Assay more info	PubMed
developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
ear development	IGI Inferred from Genetic Interaction more info	PubMed
in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
induction of apoptosis	IDA Inferred from Direct Assay more info	PubMed
induction of apoptosis	ISO Inferred from Sequence Orthology more info
kidney development	IGI Inferred from Genetic Interaction more info	PubMed
leukocyte homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
leukocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
lymphocyte homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
lymphocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
male gonad development	IGI Inferred from Genetic Interaction more info	PubMed
mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
myeloid cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of neuron apoptosis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein homooligomerization	ISO Inferred from Sequence Orthology more info
positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
post-embryonic organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
regulation of developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
spleen development	IGI Inferred from Genetic Interaction more info	PubMed
thymus development	IGI Inferred from Genetic Interaction more info	PubMed
tube formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
BIM-BCL-2 complex	ISO Inferred from Sequence Orthology more info
BIM-BCL-xl complex	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	ISO Inferred from Sequence Orthology more info
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info
peripheral to membrane of membrane fraction	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: bcl-2-like protein 11

Names: bcl-2-like protein 11; bcl2-L-11; Bcl2 interacting mediator of cell death; bcl2-interacting mediator of cell death

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009754.3 → NP_033884.1 bcl-2-like protein 11 isoform 3

Status: VALIDATED

Source sequence(s)

AA881651, AF032461, AK037885, AK082613, BE136124, CA321725, CB521709

Consensus CDS

CCDS16712.1

UniProtKB/Swiss-Prot

O54918

UniProtKB/TrEMBL

Q3U7X3

UniProtKB/TrEMBL

Q542N5

Related

ENSMUSP00000099500, OTTMUSP00000016365, ENSMUST00000103211, OTTMUST00000036403

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 114

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 79
Blast Score: 128

Bclx_interact; Bcl-x interacting
NM_207680.2 → NP_997563.1 bcl-2-like protein 11 isoform 1

Status: VALIDATED

Source sequence(s)

AA881651, AK037885, AK082613, BE136124, CA321725, CB521709

Consensus CDS

CCDS16713.1

UniProtKB/Swiss-Prot

O54918

UniProtKB/TrEMBL

Q542N5

Related

ENSMUSP00000105970, OTTMUSP00000016362, ENSMUST00000110341, OTTMUST00000036398

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 105

Bim_N; Bim protein N-terminus

pfam08945
Location:127 – 165
Blast Score: 150

Bclx_interact; Bcl-x interacting
NM_207681.2 → NP_997564.1 bcl-2-like protein 11 isoform 2

Status: VALIDATED

Source sequence(s)

AA881651, AK037885, AK050192, AK082613, BE136124, CA321725, CB521709

Consensus CDS

CCDS16714.1

UniProtKB/Swiss-Prot

O54918

UniProtKB/TrEMBL

Q542N5

Related

ENSMUSP00000099499, OTTMUSP00000016364, ENSMUST00000103210, OTTMUST00000036402

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 107

Bim_N; Bim protein N-terminus

pfam08945
Location:71 – 109
Blast Score: 141

Bclx_interact; Bcl-x interacting

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38 C57BL/6J

Range

128126038..128162547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

129356352..129393704

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AF302804.1	None	129/SvJ
genomic	AL805950.11	CAM14742.1
		CAM14743.1
		CAM14744.1
		CAM14745.1
genomic	CH466519.1	EDL28212.1	mixed
		EDL28213.1	mixed
		EDL28214.1	mixed
mRNA	AA275665.1	None	BALB/c
mRNA	AA881651.1	None	C57BL/6J
mRNA	AF032459.1	AAC40029.1
mRNA	AF032460.1	AAC40030.1
mRNA	AF032461.1	AAC40031.1
mRNA	AK011490.1	None	C57BL/6J
mRNA	AK031285.1	None	C57BL/6J
mRNA	AK037885.1	None	C57BL/6J
mRNA	AK050192.1	None	C57BL/6J
mRNA	AK082613.1	BAC38548.1	C57BL/6J
mRNA	AK150464.1	BAE29581.1	C57BL/6J
mRNA	AK152472.1	BAE31246.1	C57BL/6J
mRNA	AK153542.1	BAE32079.1	C57BL/6J
mRNA	AK162975.1	BAE37144.1	C57BL/6J
mRNA	AK177547.1	None
mRNA	BC019556.1	AAH19556.1	FVB/N
mRNA	BC058175.1	AAH58175.1
mRNA	BE136124.1	None
mRNA	CA321725.1	None	C57BL/6
mRNA	CB521709.1	None	C57BL/6

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O54918.1	GenPept	UniProtKB/Swiss-Prot:O54918
Q3TR86	GenPept	UniProtKB/TrEMBL:Q3TR86
Q3U7X3	GenPept	UniProtKB/TrEMBL:Q3U7X3
Q542N5	GenPept	UniProtKB/TrEMBL:Q542N5
Q6PEB3	GenPept	UniProtKB/TrEMBL:Q6PEB3