Bid BH3 interacting domain death agonist [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Bidprovided by MGI
Official Full Name: BH3 interacting domain death agonistprovided by MGI
Primary source: MGI:108093
See related: Ensembl:ENSMUSG00000004446; Vega:OTTMUSG00000024186
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AI875481; AU022477; 2700049M22Rik

Genomic context

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Location :: 6 F1; 6 57.02 cM

Sequence :: Chromosome: 6; NC_000072.6 (120893119..120916820, complement)

See Bid in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Three cathepsin D-specific cleavage sites in Bid, Phe24, Trp48, and Phe183, were identified.
Title: Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183.
The role of the BH3-only Bcl-2 family member Bid in the response of murine hematopoietic cells initiates the DNA damage response to replicative stress.
Title: Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress.
BID controls BAX activation in AIF-mediated necroptosis.
Title: BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
Bid regulates both the phagocytotic activities and inflammatory profiles of microglia and macrophages; Bid deficiency does not impair lipopolysaccharide-induced signaling.
Title: Bid regulates the immunological profile of murine microglia and macrophages.
beta-cell apoptosis in type 1 diabetes can proceed without Fas-induced killing mediated by the BH3-only protein Bid
Title: The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse.
The Bcl-2-related proteins Bid, Bax, and Bak accelerate neutrophil apoptosis but are not essential for cell death.
Title: Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
study demonstrates a positive impact of Bid on hematopoietic regeneration mainly due to its unique effects on donor lymphopoiesis in the transplant recipients
Title: Bid is a positive regulator for donor-derived lymphoid cell regeneration in γ-irradiated recipients.
Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis.
Title: Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis.
Mutation of Cav-1 Y14 tyrosine to phenylalanine (Y14F) disrupted the hyperoxia-induced interaction between BID and Cav-1 and subsequently yielded a decreased level of tBID and resistance to hyperoxia-induced apoptosis.
Title: Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis.
BH3-only activator proteins Bid and Bim are dispensable for Bax activation and mitochondrial apoptosis induced by Bcl-xL deficiency
Title: BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.

Submit: New GeneRIF Correction See all (86)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation
Targeted (knock-in) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_031570.2	NP_033871.1	Bcl2	BIND	PubMed	BCL-2 interacts with BID. This interaction was modelled on a demonstrated interaction between mouse BCL-2 and human BID.
BioGRID:198349	BioGRID:106962	ATM	BioGRID	PubMed	Biochemical Activity
BioGRID:198349	BioGRID:107027	ATR	BioGRID	PubMed	Biochemical Activity
BioGRID:198349	BioGRID:198304	Bax	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:198349	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Activation and oligomerization of BAK protein, organism-specific biosystem (from REACTOME)
Activation and oligomerization of BAK protein, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
Activation of BAD and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
Activation of BH3-only proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem (from REACTOME)
Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation, translocation and oligomerization of BAX, organism-specific biosystem (from REACTOME)
Activation, translocation and oligomerization of BAX, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
Apoptosis Modulation by HSP70, organism-specific biosystem
Apoptosis Modulation by HSP70
Apoptosis signaling pathway, organism-specific biosystem (from LIPID MAPS)
Apoptosis signaling pathway, organism-specific biosystem
Apoptosis signaling pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
p53 signaling pathway, organism-specific biosystem (from KEGG)
p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53 signaling pathway, conserved biosystem (from KEGG)
p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

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Markers

AU022477 (e-PCR)
- UniSTS:159565

AI875481 (e-PCR)
- UniSTS:165485

Bid (e-PCR), detects polymorphism
- UniSTS:141176

Bid (e-PCR), detects polymorphism
- UniSTS:141177

AU022477 (e-PCR)
- UniSTS:208023

Homology

Homologs of the Bid gene: The Bid gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
apoptotic mitochondrial changes	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	IDA Inferred from Direct Assay more info	PubMed
establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of protein homooligomerization	IDA Inferred from Direct Assay more info
positive regulation of protein homooligomerization	ISO Inferred from Sequence Orthology more info
positive regulation of protein oligomerization	ISO Inferred from Sequence Orthology more info
positive regulation of release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of mitochondrial membrane permeability	IGI Inferred from Genetic Interaction more info	PubMed
release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	ISO Inferred from Sequence Orthology more info
integral to mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BH3-interacting domain death agonist

Names: BH3-interacting domain death agonist; p22 BID

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007544.3 → NP_031570.2 BH3-interacting domain death agonist

Status: PROVISIONAL

Source sequence(s)

BC002031

Consensus CDS

CCDS20486.1

UniProtKB/Swiss-Prot

P70444

Related

ENSMUSP00000004560, OTTMUSP00000028756, ENSMUST00000004560, OTTMUST00000059168

Conserved Domains (1) summary

pfam06393
Location:1 – 192
Blast Score: 745

BID; BH3 interacting domain (BID)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 129S1/SvImJ

Genomic

NT_039382.4 Reference GRCm38.p1 129S1/SvImJ

Range

517736..541471, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38.p1 C57BL/6J

Range

120893119..120916820, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

122736915..122760652, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01057037.1 (52026..75763)	None
genomic	AC006404.25 (118183..141918)	None	129/Sv
genomic	AC006945.17 (1907..25642)	None	129/Sv
genomic	AC083894.21 (53931..77632)	None	C57BL/6J
genomic	CH466523.1	EDK99650.1	mixed
		EDK99651.1	mixed
mRNA	AK045731.1	BAC32475.1	C57BL/6J
mRNA	AK051076.1	BAC34518.1	C57BL/6J
mRNA	AK052356.1	BAC34955.1	C57BL/6J
mRNA	AK077657.1	BAC36932.1	C57BL/6J
mRNA	AK161235.1	BAE36258.1	C57BL/6J
mRNA	AK177453.1	None
mRNA	BC002031.1	AAH02031.1
mRNA	U75506.1	AAC71064.1