Nkx3-2 NK3 homeobox 2 [Mus musculus] - Gene

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Summary

Official Symbol: Nkx3-2provided by MGI
Official Full Name: NK3 homeobox 2provided by MGI
Primary source: MGI:108015
See related: Ensembl:ENSMUSG00000049691; Vega:OTTMUSG00000036567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bapx1; NKX3.2; Nkx-3.2

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Genomic context

Location :: 5 B3; 5 23.0 cM

Sequence :: Chromosome: 5; NC_000071.6 (41761483..41764220, complement)

See Nkx3-2 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrated that Nkx3.2-dependent suppression of Runx2 was a crucial factor in hypoxia-dependent maintenance of chondrocyte identity.
Title: Nkx3.2-induced suppression of Runx2 is a crucial mediator of hypoxia-dependent maintenance of chondrocyte phenotypes.
Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha.
Title: Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.
Results reveal that the molecular pathway modulated by Bapx1 links two major regulators in chondrogenesis, Sox9 and Runx2, to coordinate skeletal formation.
Title: Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.
A regulatory mutation, (-519G-->A) within the neu1 promoter generates a consensus binding site for Nkx3 family transcription repressors.
Title: A point mutation in the neu1 promoter recruits an ectopic repressor, Nkx3.2 and results in a mouse model of sialidase deficiency.
Nkx3.2 has a critical role in the induction of somitic chondrogenesis
Title: Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis.
Bapx1 plays a crucial organizing role effecting position and separation of the spleen and pancreas to prevent metaplastic transformation
Title: Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.
in the Bapx1 mutant embryo, Fgf10 expression is downregulated and the dorsal pancreas remains at the midline
Title: The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.
Nkx3.2 represses expression of the chondrocyte maturation factor Runx2, and Runx2 mis-expression can rescue the Nkx3.2-induced blockade of chondrocyte maturation.
Title: Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation.
Pax1 and Pax9 can transactivate regulatory sequences in the Bapx1 promoter to induce chondrogenic differentiation in the sclerotome.
Title: Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome.
Targeted disruption of the Nkx3.2 (Bapx1) gene in mice results in limited defects of chondrocranial bones and the axial skeleton, particularly pronounced in cervical vertebrae.
Title: Transcription factors Nkx3.1 and Nkx3.2 (Bapx1) play an overlapping role in sclerotomal development of the mouse.

Submit: New GeneRIF Correction See all (13)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation
Targeted (Reporter) (3) 1 citation
Targeted (knock-in) (4) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:198300	BioGRID:198403	Btrc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198300	BioGRID:200601	Ikbkb	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:198300	BioGRID:200602	Ikbkg	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198300	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
digestive system development	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
intestinal epithelial cell development	IGI Inferred from Genetic Interaction more info
middle ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
organ development	IMP Inferred from Mutant Phenotype more info	PubMed
organ formation	IMP Inferred from Mutant Phenotype more info	PubMed
pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: homeobox protein Nkx-3.2

Names: homeobox protein Nkx-3.2; homeodomain protein Nkx-3.2; bagpipe homeobox gene 1 homolog; homeobox protein NK-3 homolog B; bagpipe homeobox protein homolog 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007524.3 → NP_031550.2 homeobox protein Nkx-3.2

Status: VALIDATED

Source sequence(s)

BC145874, U87957

Consensus CDS

CCDS19259.1

UniProtKB/Swiss-Prot

P97503

Related

ENSMUSP00000051990, OTTMUSP00000052105, ENSMUST00000060820, OTTMUST00000093782

Conserved Domains (1) summary

cd00086
Location:213 – 265
Blast Score: 181

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38 C57BL/6J

Range

41761483..41764220, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

39220946..39223683, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC102858.11 (76293..79065)	None
genomic	CH466524.1	EDL37578.1	mixed
mRNA	BC021014.1	None	FVB/N
mRNA	BC145872.1	AAI45873.1
mRNA	BC145874.1	AAI45875.1
mRNA	U87957.1	AAB47764.1
mRNA	U88716.1	AAB48514.1