My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CLK3 CDC-like kinase 3 [ Homo sapiens ]

    Gene ID: 1198, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    CLK3provided by HGNC
    Official Full Name
    CDC-like kinase 3provided by HGNC
    Primary source
    HGNC:2071
    See related
    Ensembl:ENSG00000179335; HPRD:04290; MIM:602990; Vega:OTTHUMG00000141320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PHCLK3; PHCLK3/152; FLJ22858
    Summary
    This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    15q24
    Sequence :
    Chromosome: 15; NC_000015.9 (74900713..74922542)
    See CLK3 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC440288 Neighboring gene AT rich interactive domain 3B (BRIGHT-like) Neighboring gene enhancer of mRNA decapping 3 homolog (S. cerevisiae) Neighboring gene cytochrome P450, family 1, subfamily A, polypeptide 1

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. Giannone RJ, et al. PLoS One, 2010 Aug 25. PMID 20811636.
    3. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087.
    4. [Expression of cell cycle molecules in human azoospermic testes]. Yang B, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2009 May. PMID 19426592.
    5. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Eisenreich A, et al. Circ Res, 2009 Mar 13. PMID 19168442.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. regulated but the expression of CDK9, CDC20 and CLK3 was down- regulated in azoospermic testes.
      Title: [Expression of cell cycle molecules in human azoospermic testes].
    2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
      Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P49761 Chromosome 1 open reading frame 63 C1orf63    HPRD  PubMed  
    P49761 P49760 CLK2    HPRD  PubMed  
    P49761 P61981 YWHAG    HPRD  PubMed  
    BioGRID:107609 BioGRID:121332 C1orf63    BioGRID  PubMed Two-hybrid 
    BioGRID:107609 BioGRID:107607 CLK2    BioGRID  PubMed Two-hybrid 
    BioGRID:107609 BioGRID:110811 NEDD4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107609 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107609 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107609 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107609 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    dual specificity protein kinase CLK3
    Names
    dual specificity protein kinase CLK3
    NP_001123500.1
    NP_003983.2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130028.1 → NP_001123500.1  dual specificity protein kinase CLK3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK091692, BC002555, BQ183959
      Consensus CDS
      CCDS45304.1
      UniProtKB/TrEMBL
      B3KRI8
      UniProtKB/Swiss-Prot
      P49761
      Related
      ENSP00000378505, OTTHUMP00000233457, ENST00000395066, OTTHUMT00000390442
      Conserved Domains (2) summary
      smart00220
      Location:304 – 620
      Blast Score: 553
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:304 – 620
      Blast Score: 378
      PKc_like; Protein Kinases, catalytic domain

    2. NM_003992.4 → NP_003983.2  dual specificity protein kinase CLK3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      BC002555, BQ183959, L29217
      Consensus CDS
      CCDS10265.1
      UniProtKB/Swiss-Prot
      P49761
      Related
      ENSP00000344112, OTTHUMP00000180678, ENST00000345005, OTTHUMT00000280687
      Conserved Domains (2) summary
      smart00220
      Location:156 – 472
      Blast Score: 527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:156 – 472
      Blast Score: 365
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      74900713..74922542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      51698874..51720703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001292.1: Suppressed sequence

      Description
      NM_001292.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC100835.2 (83968..105713) None
    genomic CH471136.2 EAW99320.1
      EAW99321.1
      EAW99322.1
      EAW99323.1
      EAW99324.1
      EAW99325.1
    mRNA AK026511.1 None
    mRNA AK091692.1 BAG52400.1
    mRNA AK096115.1 BAG53214.1
    mRNA AK097982.1 BAG53559.1
    mRNA AK122860.1 BAG53765.1
    mRNA AK225680.1 None
    mRNA AK291983.1 BAF84672.1
    mRNA AK293769.1 BAG57185.1
    mRNA AK301689.1 BAG63161.1
    mRNA AL833165.1 None
    mRNA BC002555.2 AAH02555.1
    mRNA BC006103.1 AAH06103.1
    mRNA BC009857.2 None
    mRNA BC019881.1 AAH19881.1
    mRNA BI459843.1 None
    mRNA BM678884.1 None
    mRNA BQ183959.1 None
    mRNA BT006993.1 AAP35639.1
    mRNA CR933693.1 None
    mRNA L29217.1 AAA61484.1
    mRNA L29220.1 AAA61483.1
    mRNA AB209535.1 BAD92772.1
    other-genetic JF432199.1 ADZ15416.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49761.3 GenPept UniProtKB/Swiss-Prot:P49761
    Q59FC5 GenPept UniProtKB/TrEMBL:Q59FC5
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...