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CLK3 CDC like kinase 3 [ Homo sapiens (human) ]

Gene ID: 1198, updated on 26-May-2016
Official Symbol
CLK3provided by HGNC
Official Full Name
CDC like kinase 3provided by HGNC
Primary source
HGNC:HGNC:2071
See related
Ensembl:ENSG00000179335 HPRD:04290; MIM:602990; Vega:OTTHUMG00000141320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHCLK3; PHCLK3/152
Summary
This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
Orthologs
Location:
15q24
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (74598476..74645418)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74898327..74922542)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723714 Neighboring gene AT-rich interaction domain 3B Neighboring gene uncharacterized LOC102723750 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene cytochrome P450 family 1 subfamily A member 1 Neighboring gene cytochrome P450 family 1 subfamily A member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.
NHGRI GWA Catalog
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22858

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dual specificity protein kinase CLK3
Names
CDC-like kinase 3
NP_001123500.1
NP_003983.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130028.1NP_001123500.1  dual specificity protein kinase CLK3 isoform a

    See identical proteins and their annotated locations for NP_001123500.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK091692, BC002555, BQ183959
    Consensus CDS
    CCDS45304.1
    UniProtKB/Swiss-Prot
    P49761
    UniProtKB/TrEMBL
    B3KRI8
    Related
    ENSP00000378505, OTTHUMP00000233457, ENST00000395066, OTTHUMT00000390442
    Conserved Domains (3) summary
    smart00220
    Location:304620
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14214
    Location:290620
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3
    TIGR04469
    Location:4144
    CGA_synth_rel; CGA synthase-related protein
  2. NM_003992.4NP_003983.2  dual specificity protein kinase CLK3 isoform b

    See identical proteins and their annotated locations for NP_003983.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    BC002555, BQ183959, L29217
    Consensus CDS
    CCDS10265.1
    UniProtKB/Swiss-Prot
    P49761
    Related
    ENSP00000344112, OTTHUMP00000180678, ENST00000345005, OTTHUMT00000280687
    Conserved Domains (2) summary
    smart00220
    Location:156472
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14214
    Location:142472
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    74598476..74645418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254153.3XP_005254210.1  

    See identical proteins and their annotated locations for XP_005254210.1

    UniProtKB/Swiss-Prot
    P49761
    Conserved Domains (2) summary
    smart00220
    Location:156472
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14214
    Location:142472
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3
  2. XM_011521208.1XP_011519510.1  

    Conserved Domains (2) summary
    smart00220
    Location:170413
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:156446
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011521210.1XP_011519512.1  

    See identical proteins and their annotated locations for XP_011519512.1

    Conserved Domains (2) summary
    smart00220
    Location:156399
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:142432
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011521205.1XP_011519507.1  

    Conserved Domains (3) summary
    smart00220
    Location:318561
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    TIGR04469
    Location:4144
    CGA_synth_rel; CGA synthase-related protein
    cl21453
    Location:304594
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006720384.2XP_006720447.1  

    Conserved Domains (1) summary
    cl21453
    Location:304379
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011521207.1XP_011519509.1  

    Conserved Domains (3) summary
    pfam00069
    Location:318600
    Pkinase; Protein kinase domain
    TIGR04469
    Location:4144
    CGA_synth_rel; CGA synthase-related protein
    cl21453
    Location:304595
    PKc_like; Protein Kinases, catalytic domain
  7. XM_005254151.2XP_005254208.1  

    Conserved Domains (3) summary
    smart00220
    Location:318634
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14214
    Location:304634
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3
    TIGR04469
    Location:4144
    CGA_synth_rel; CGA synthase-related protein
  8. XM_011521206.1XP_011519508.1  

    Conserved Domains (3) summary
    smart00220
    Location:304547
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    TIGR04469
    Location:4144
    CGA_synth_rel; CGA synthase-related protein
    cl21453
    Location:290580
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011521209.1XP_011519511.1  

    See identical proteins and their annotated locations for XP_011519511.1

    Conserved Domains (2) summary
    smart00220
    Location:156399
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:142432
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_931746.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    75019166..75040995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001292.1: Suppressed sequence

    Description
    NM_001292.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.